Analysis of the diversity of the HIV‐1 <i>pol</i> gene and drug resistance associated changes among drug‐naïve patients in Burkina Faso

Tebit, Denis M.; Sangaré, Lassana; Tiba, Fabrice; Yameogo, Saydou; Makamtse, Aline; Somlaré, Hermann; Bado, Guillaume; Kouldiaty, Boris G.; Zabsonre, Inoussa; Yameogo, Sibiri L.; Sathiandee, Kanokporn; Drabo, Joseph; Kräusslich, Hans‐Georg

doi:10.1002/jmv.21600

Cited by 26 publications

(25 citation statements)

References 42 publications

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“…Subtype G is the second most prevalent HIV-1 clade in West Africa accounting for nearly 30% of infections in the region [4]. Its prevalence greatly varies within and between countries, comprising 30–50% of HIV-1 infections across different regions from Nigeria [5], [6], [7], [8], [9], [10], [11], [12], 5–15% in Benin, Niger and Togo [13], [14], [15], [16], [17], and ≤4% in other western African countries [14], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]. Similarly, the occurrence of the CRF06_cpx clade ranges from 40–50% of HIV-1 infections in Burkina Faso [18], [19], [20], to 5–15% in Benin, Ghana, Mali, Niger, Nigeria, Senegal and Togo [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [21], [22], [23], [24], [28], [29], and <3% in other western African countries [14], [26], [27], [30].…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa

2014

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The human immunodeficiency virus type 1 (HIV-1) subtype G is the second most prevalent HIV-1 clade in West Africa, accounting for nearly 30% of infections in the region. There is no information about the spatiotemporal dynamics of dissemination of this HIV-1 clade in Africa. To this end, we analyzed a total of 305 HIV-1 subtype G pol sequences isolated from 11 different countries from West and Central Africa over a period of 20 years (1992 to 2011). Evolutionary, phylogeographic and demographic parameters were jointly estimated from sequence data using a Bayesian coalescent-based method. Our analyses indicate that subtype G most probably emerged in Central Africa in 1968 (1956–1976). From Central Africa, the virus was disseminated to West and West Central Africa at multiple times from the middle 1970s onwards. Two subtype G strains probably introduced into Nigeria and Togo between the middle and the late 1970s were disseminated locally and to neighboring countries, leading to the origin of two major western African clades (GWA-I and GWA-II). Subtype G clades circulating in western and central African regions displayed an initial phase of exponential growth followed by a decline in growth rate since the early/middle 1990s; but the mean epidemic growth rate of GWA-I (0.75 year−1) and GWA-II (0.95 year−1) clades was about two times higher than that estimated for central African lineages (0.47 year−1). Notably, the overall evolutionary and demographic history of GWA-I and GWA-II clades was very similar to that estimated for the CRF06_cpx clade circulating in the same region. These results support the notion that the spatiotemporal dissemination dynamics of major HIV-1 clades circulating in western Africa have probably been shaped by the same ecological factors.

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Section: Introductionmentioning

confidence: 99%

Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa

2014

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“…Both HIV-1 and HIV-2 are present in the region and two HIV-1 circulating recombinant forms (CRFs) dominate the epidemic in Burkina Faso: CRF02_AG and CRF06_cpx (Tebit et al, 2006;Tebit et al, 2009). CRFs represent recombinant HIV-1 genomes that have infected three or more persons who are not epidemiologically related, so they can be assumed to have an epidemiologically relevant contribution to the HIV-1 M group epidemic (LANL, 2016).…”

Section: Introductionmentioning

confidence: 99%

Reconstructing the HIV-1 CRF02_AG and CRF06_cpx epidemics in Burkina Faso and West Africa using early samples

Yebra

Kalish

Brown

2016

Infection, Genetics and Evolution

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“…Although these samples came from one hospital in Quagadougou, almost thirty years later the same CRFs are still predominant and co-circulating today and causing infections in Burkina Faso, with no significant change in proportion between CRF06_cpx and CRF02_AG [62], [63]; thus, strongly suggesting the same strains that initiated the early epidemic. Similarly, Kalish et al [24] found the distribution of HIV-1 strains in Kinshasa, Zaire from 1984 through 1986 were composed of CRF01_AE, unique recombinant viruses, unclassifiable strains, and all the group M subtypes but B.…”

Section: Discussionmentioning

confidence: 99%

Recombinant Viruses Initiated the Early HIV-1 Epidemic in Burkina Faso

et al. 2014

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We analyzed genetic diversity and phylogenetic relationships among 124 HIV-1 and 19 HIV-2 strains in sera collected in 1986 from patients of the state hospital in Ouagadougou, Burkina Faso. Phylogenetic analysis of the HIV-1 env gp41 region of 65 sequences characterized 37 (56.9%) as CRF06_cpx strains, 25 (38.5%) as CRF02_AG, 2 (3.1%) as CRF09_cpx, and 1 (1.5%) as subtype A. Similarly, phylogenetic analysis of the protease (PR) gene region of 73 sequences identified 52 (71.2%) as CRF06_cpx, 15 (20.5%) as CRF02_AG, 5 (6.8%) as subtype A, and 1 (1.4%) was a unique strain that clustered along the B/D lineage but basal to the node connecting the two lineages. HIV-2 PR or integrase (INT) groups A (n = 17 [89.5%]) and B (n = 2 [10.5%]) were found in both monotypic (n = 11) and heterotypic HIV-1/HIV-2 (n = 8) infections, with few HIV-2 group B infections. Based on limited available sampling, evidence suggests two recombinant viruses, CRF06_cpx and CRF02_AG, appear to have driven the beginning of the mid-1980s HIV-1 epidemic in Burkina Faso.

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Analysis of the diversity of the HIV‐1 pol gene and drug resistance associated changes among drug‐naïve patients in Burkina Faso

Cited by 26 publications

References 42 publications

Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa

Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa

Reconstructing the HIV-1 CRF02_AG and CRF06_cpx epidemics in Burkina Faso and West Africa using early samples

Recombinant Viruses Initiated the Early HIV-1 Epidemic in Burkina Faso

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