Analysis of the effects of trifluoromethyl group on the conformational properties of meta substituted thioacetanilide

Introducing Bis(5-(Trifluoromethyl)pyridin-2-yl)amine Chelating Unit via Pd-Catalyzed Amination

“…Metal complexes of bis(pyridin-2-yl)amine-based ligands demonstrate luminescent properties [11], possess cytotoxic activity and can bind with DNA molecules [12][13][14][15]. Introducing fluorine-containing groups to the molecule's structure is in demand because of the influence of such moieties on electronic properties, solubility, conformations and the lipophilicity of the compound [16][17][18][19][20]. Synthesis of dpa derivatives can be performed via N-alkylation [1] or N-arylation [2,3] of dpa or by N,N-diarylation of amines with 2-halogenosubtituted pyridine [21,22].…”