Analysis of the essential oil from Lantana camara leaves and its cytotoxic potential against T-47D breast cancer cells

Suryati, Suryati; Aziz, Enda Desriansyah; Efdi, Mai; Wahyuni, Fatma Sri; Hefni, Dira

doi:10.25077/jrk.v12i1.364

Cited by 4 publications

(8 citation statements)

References 21 publications

(27 reference statements)

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“…Sampel diinjeksikan sebanyak 0,1 μL dengan split ratio 200:1, suhu injektor dan detektor diatur 250 °C -280 °C. Gas pembawanya adalah gas helium Ultra High Purity (UHP) dengan laju alir 240 mL/menit [12] .…”

Section: Analisis Komponen Minyak Atsiri Dengan Gc-msunclassified

“…Artikel ini melaporkan kandungan kimia minyak atsiri yang diisolasi dari daun pucuk merah dan potensinya sebagai antibakteri dan toksisitas, isolasi minyak atsiri dilakukan dengan hidrodistilasi [12] , analisis kandungan kimia minyak atsiri hasil isolasi dilakukan dengan metode Gas Chromatography-Mass Spectrometry (GC-MS) [10] , Uji aktivitas antibakteri dilakukan dengan metode difusi cakram terhadap bakteri Escherichia coli sebagai bakteri gram negatif dan Staphylococcus aureus sebagai bakteri gram positif [13] . Pemilihan jenis bakteri ini juga didasarkan pada penggunaan daun pucuk merah untuk obat diare dan kram perut [2] .…”

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Komponen Kimia Minyak Atsiri yang Diisolasi dari Daun Tanaman Pucuk Merah (Syzygium myrtifolium Walp.) dan Potensi Antibakteri serta Toksisitasnya

et al. 2023

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Pucuk merah (Syzygium myrtifolium Walp.) is an ornamental plant from the Myrtaceae family. Several phytochemical tests from previous researchers reported that pucuk merah contains secondary metabolites that have benefits such as antioxidants, antibacterials, and anti-cancer. In addition, the distinctive aroma produced from pucuk merah leaves indicates the presence of essential oils whose bioactivity can be studied. Still, there has been no report on this plant's chemical components or bioactivity. Therefore, this study aims to determine the content of chemical components of pucuk merah essential oil and their bioactivity as antibacterial and toxicity. The isolation of essential oils was carried out by the hydro distillation method. The chemical components of essential oils were analyzed using the Gas Chromatography-Mass Spectrometry (GC-MS) method. GC-MS results showed the presence of 42 compounds with four main compounds, namely caryophyllene (23.45%), 3-carene (15.67%), α-terpineol (10.74%), and α-pinene (5.98%) ). Antibacterial test of pucuk merah essential oil using the disc diffusion method showed strong activity against Staphylococcus aureus and Escherichia coli with inhibition zones of 16.15 ± 2.03 and 16.13 ± 1.74 mm at 100% concentration. The results of the toxicity test of pucuk merah essential oil using the BSLT (Brine Shrimp Lethality Test) method on Artemia salina Leach shrimp larvae showed strong toxic properties with an LC50 value of 3.99 µg/mL.

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Section: Analisis Komponen Minyak Atsiri Dengan Gc-msunclassified

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Komponen Kimia Minyak Atsiri yang Diisolasi dari Daun Tanaman Pucuk Merah (Syzygium myrtifolium Walp.) dan Potensi Antibakteri serta Toksisitasnya

et al. 2023

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“…Nilai m/z 58-500 AMU. Hasil analisis senyawa, diidentifikasi menggunakan perbandingan dengan data National Institute of Standard and Technologies (NIST) 14 [14] .…”

Section: Analisis Komponen Minyak Atsiri Biji Jintan Dengan Gc-msunclassified

“…Pengerjaan yang sama juga dilakukan terhadap larutan kontrol (metanol), kemudian setelah 24 jam dihitung larva udang yang mati. Jumlah larva udang yang mati pada masingmasing larutan uji digunakan untuk menghitung nilai LC50 melalui analisis probit dan persamaan regresi [14] .…”

Section: Uji Toksisitasunclassified

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Potensi Antimikroba dan Toksisitas Minyak Atsiri yang Diisolasi dari Biji Jintan (Carum carvi L.)

Suryati

Salim²,

Elizar³

2022

J.Ris.Kim.

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Caraway (Carum carvi L.) is one of the oldest medicinal plants found in various countries such as West Asia, North Africa, Pakistan, India, North America, Northern Europe, Iran, Russia, and Indonesia. This plant has been use for traditional medicines to treat digestive disorders, flatulence, colic in infants, headaches, coughs, hypertension, eczema, pneumonia, diabetes, scabies, mouthwash and as an antiseptic. This plant is reported to contain around 1-9% essential oil in the seeds with various components and potential as bioactive compounds. In this study, essential oils were isolated from caraway seeds and determined their chemical content as well as their antimicrobial and toxicity. Isolation of essential oils was carried out by hydrodistillation and analysis of the chemical components of the isolated essential oils was carried out using the Gas Chromatography-Mass Spectrometry (GC-MS) method. The results of the GC-MS analysis showed the presence of 35 compounds with four main compounds, namely carvone (62.54%), limonene (23.39%), and trans-dihydrocarvone (8.20%). The antimicrobial activity test was carried out using the disc diffusion method, which showed strong activity against Staphylococcus aureus at a concentration of ≥75%, and against the fungus Candida albicans. The results of the toxicity test using the Brine Shrimp Lethality Test (BSLT) method showed that caraway seed essential oil was low toxic against Artemia salina Leach shrimp larvae with an LC50 value 568.3292 mg/L.

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Toxicity assessment and anti‐Vibrio activity of essential oils: Potential for application in shrimp aquaculture

Zheng

Bossier

2023

Reviews in Aquaculture

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This present paper aimed to review the past 4 years (2019–2022), the inhibition of Vibrio spp. (including Vibrio's causing AHPND) by EOs, as well as the potential toxicity of the EOs towards crustaceans, with an emphasis on Artemia spp. In the present review, 27 EOs from terrestrial plants are reported regarding their anti‐Vibrio activity. Among these 27 studies, Salvia officinalis and Thymus vulgaris (Lamiaceae family) were found to be the most numerous. Among the Vibrio spp., V. parahaemolyticus (non‐AHPND strain) was mostly researched. There are in total 68 publications about the toxicity of EOs in Artemia spp. Based on the four categories of toxicity towards Artemia (strongly toxic: LC50 < 100 μg/ml, moderately toxic: LC50:100–500 μg/ml, weakly toxic: LC50: 500–1000 μg/ml, and non‐toxic: LC50 > 1000 μg/ml), strong toxicity activity was found in 37 EOs, moderate toxicity in 15 EOs, weak activity for three EO plants and 13 non‐toxic extracts. In fact, LC50 values as low as 10.25 and 11.48 μg/ml were described in Artemisia vulgaris and Euryale ferox, respectively, showing these two plant EOs are strongly toxic to Artemia. Overall, and despite being generally considered “eco‐friendly and natural” products and safer than antibiotics, some of the EOs are toxic to target organisms. Thus, to establish an ecologically safe application of EOs in shrimp aquaculture, the correct use of these plant EOs (in terms of concentrations and duration) in aquaculture should be considered.

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Analysis of the essential oil from Lantana camara leaves and its cytotoxic potential against T-47D breast cancer cells

Cited by 4 publications

References 21 publications

Komponen Kimia Minyak Atsiri yang Diisolasi dari Daun Tanaman Pucuk Merah (Syzygium myrtifolium Walp.) dan Potensi Antibakteri serta Toksisitasnya

Komponen Kimia Minyak Atsiri yang Diisolasi dari Daun Tanaman Pucuk Merah (Syzygium myrtifolium Walp.) dan Potensi Antibakteri serta Toksisitasnya

Potensi Antimikroba dan Toksisitas Minyak Atsiri yang Diisolasi dari Biji Jintan (Carum carvi L.)

Toxicity assessment and anti‐Vibrio activity of essential oils: Potential for application in shrimp aquaculture

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