1996
DOI: 10.1046/j.1537-2995.1996.36296181931.x
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Analysis of the expression of NB1 antigen using two monoclonal antibodies

Abstract: NB1 specificity is made up of at least two separate epitopes. The expression of NB1 varied among antigen-positive individuals. While NB1 is expressed by a 56- to 64-kDa glycoprotein, the structure of this protein on antigen-negative cells has not been determined.

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Cited by 38 publications
(45 citation statements)
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“…More impressive upregulation was seen for the neutrophil-specific NB1 antigen, CD177. 22,23 CD66b expression on neutrophils from the granulocyte donors was upregulated compared to that on control cells. On the other hand, surface expression of CD11b and CD18, which are partially expressed in the same compartments as CD66b, was similar.…”
Section: G-csf/dexamethasone Exposure Changes the Granulocyte Phenotypementioning
confidence: 84%
“…More impressive upregulation was seen for the neutrophil-specific NB1 antigen, CD177. 22,23 CD66b expression on neutrophils from the granulocyte donors was upregulated compared to that on control cells. On the other hand, surface expression of CD11b and CD18, which are partially expressed in the same compartments as CD66b, was similar.…”
Section: G-csf/dexamethasone Exposure Changes the Granulocyte Phenotypementioning
confidence: 84%
“…18,19 The binding characteristic of TAG4 was almost identical to that of 7D8 (a generous gift from Dr Stroncek, National Institutes of Health, Bethesda, MD). 20,21,22 The genotypes of HNA-1 antigens were determined by using a modification of polymerase chain reaction methods previously reported. 23,24 GIIFT and micro-leukocyte agglutination test GIIFT and micro-leukocyte agglutination test (MLAT) were performed by using a modification of the previously described method.…”
Section: Preparation Of Monoclonal Antibodies To Neutrophil-specific mentioning
confidence: 99%
“…CD177 (NB1 and PRV-1) is a 58-to 64-kDa glycosylphosphatidylinositol-anchored glycoprotein expressed exclusively by neutrophils, neutrophilic metamyelocytes, and myelocytes, but not by any other blood cells (1,2). We and others elucidated its primary structure by sequencing the NB1 and PRV-1 genes, which later turned out to be two alleles of a single CD177 gene (3)(4)(5).…”
mentioning
confidence: 99%
“…We and others elucidated its primary structure by sequencing the NB1 and PRV-1 genes, which later turned out to be two alleles of a single CD177 gene (3)(4)(5). The surface expression of CD177 is unique in that only a subpopulation of neutrophils expresses this protein on the cell surface, with the mean size of the CD177-positive subpopulation ranging from 45% to 65% (2,6).…”
mentioning
confidence: 99%
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