2012
DOI: 10.1016/j.fertnstert.2012.02.021
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Analysis of the expression of neurokinin B, kisspeptin, and their cognate receptors NK3R and KISS1R in the human female genital tract

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Cited by 105 publications
(46 citation statements)
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“…This is consistent with previous reports that the concentration of kisspeptin is seen to increase during the pre‐ovulatory period and the luteal phase during the menstrual cycle . It is known that kisspeptin is expressed in the ovarian granulosa‐lutein cells and theca cells of growing follicles and the rise in plasma kisspeptin concentration coincides with the time when the expression of kisspeptin increases in the ovary. Although there are multiple expression sites of kisspeptin in the peripheral organs, the concentrations show a constant fluctuation in the short period of ovarian stimulation; thus, an increase in kisspeptin in the ovary accompanying follicular growth might contribute to an increase in plasma concentrations.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…This is consistent with previous reports that the concentration of kisspeptin is seen to increase during the pre‐ovulatory period and the luteal phase during the menstrual cycle . It is known that kisspeptin is expressed in the ovarian granulosa‐lutein cells and theca cells of growing follicles and the rise in plasma kisspeptin concentration coincides with the time when the expression of kisspeptin increases in the ovary. Although there are multiple expression sites of kisspeptin in the peripheral organs, the concentrations show a constant fluctuation in the short period of ovarian stimulation; thus, an increase in kisspeptin in the ovary accompanying follicular growth might contribute to an increase in plasma concentrations.…”
Section: Discussionsupporting
confidence: 92%
“…In contrast, recently it has been reported that kisspeptin is expressed in granulosa‐lutein cells and theca cells in the ovary . There are reports that, if a kisspeptin antagonist is locally administered to the ovary, delayed vaginal opening and a disorder of the estrous cycle occur, and that mice heterozygous for kisspeptin receptors are in the same state as premature ovarian failure .…”
Section: Introductionmentioning
confidence: 98%
“…The pituitary, which is vital in the control of metabolic homeostasis and reproduction, highly expresses Rfrp, GnIHR, Kiss1, and Kiss1r (Lee et al 1996, Muir et al 2001, Ohtaki et al 2001, Shahab et al 2005, Ubuka et al 2009b, Smith et al 2010a,b, Tsutsui et al 2010, Wahab et al 2011a, Cejudo Roman et al 2012, Irfan et al 2014.…”
Section: Kp and Gnih Signaling In Conditions Of Altered Energy Balancmentioning
confidence: 99%
“…By acting through its G‐protein coupled receptor, Kiss1‐R, Kiss1 centrally stimulates pulsatile GnRH release (Funes et al., ; Seminara et al., ). Kiss1 and its receptor were also found in human and rat ovarian tissues, as well as in granulosa‐lutein cells in vitro (Cejudo Roman et al., ; Gaytan et al., ). Also, the presence of GnRH‐R transcripts was confirmed in ovarian follicles and corpus luteum (CL), for example in mouse (Torrealday, Lalioti, Guzeloglu‐Kayisli, & Seli, ) and human (Choi, Gilks, Auersperg, & Leung, ).…”
Section: Introductionmentioning
confidence: 98%