Analysis of the Expression of Exostosins and Clinicopathological Features in Membranous Lupus Nephritis in a Chinese Cohort

Li, Huixian; Lan, Ping; Yu, Xiaoyang; Liu, Xiaoling; Sun, Jiping; Xie, Liyi; Lu, Wanhong; Xie, Xinfang

doi:10.1016/j.ekir.2022.07.164

Cited by 7 publications

(8 citation statements)

References 9 publications

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“…Neither Xie et al. 15 nor our study found statistical differences; however, we both clarified that EXT1/EXT2-positive patients were prone to show greater proteinuria. Though remaining unexplained and elusive, one hypothesis was that the EXT1/EXT2 as glycosyltransferases being transported from podocytes to GBM might facilitate the synthesis of the heparan sulfates.…”

Section: Discussioncontrasting

confidence: 93%

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Glomerular Exostosin-Positivity is Associated With Disease Activity and Outcomes in Patients With Membranous Lupus Nephritis

Xia,

Li,

Wang

et al. 2024

Kidney International Reports

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Section: Discussioncontrasting

confidence: 93%

“… 6 and Xie et al. 15 found that the EXT-positive rate among the pure class V cases and mixed class V MLN were similar. Our cohort had the largest sample of 170 patients with mixed class V MLN whereas there were only 47 to 111 patients with mixed class V MLN in other studies.…”

Section: Discussionmentioning

confidence: 90%

Glomerular Exostosin-Positivity is Associated With Disease Activity and Outcomes in Patients With Membranous Lupus Nephritis

Xia,

Li,

Wang

et al. 2024

Kidney International Reports

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“…Recent research suggests that EXT1/EXT2-positive MN may help identify LMN, and no individual case demonstrated positivity for just a single EXT marker. 20 Furthermore, EXT1 exhibited a stronger positive intensity in glomeruli compared with EXT2. 21 Therefore, we chose EXT1 as the representative marker for detection.…”

Section: Discussionmentioning

confidence: 95%

Clinical significance of exostosin 1 in confirmed and suspected lupus membranous nephropathy

Ye,

Jiang,

Zeng

et al. 2023

Lupus Sci Med

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ObjectiveThis study aimed to investigate the clinical significance of exostosin 1 (EXT1) in confirmed and suspected lupus membranous nephropathy (LMN).MethodsEXT1 was detected in 67 renal tissues of M-type phospholipase A2 receptor (PLA2R)-negative and ANA-positive membranous nephropathy by immunohistochemistry, and cases were divided into confirmed LMN and suspected LMN. The clinicopathological data were compared among the above groups, as well as EXT1-positive group and EXT1-negative group.ResultsTwenty-two cases (73.3%) of confirmed LMN and six cases (16.2%) of suspected LMN exhibited EXT1 expression on the glomerular basement membrane and/or mesangium area, showing a significant difference (p<0.001). Concurrently, lupus nephritis (LN) of pure class V demonstrated a lower frequency of EXT1 positivity compared with mixed class V LN in the confirmed LMN group (31.8% vs 68.2%, p=0.007). EXT1-positive patients in the confirmed and suspected LMN group showed significant differences in some clinicopathological data comparing with EXT1-negative patients (p<0.05). Follow-up data revealed that a greater proportion of patients in the EXT1-positive group achieved complete remission post-treatment (p<0.05). Cox regression analysis showed that EXT1 positivity was significantly correlated with complete remission across the entire study cohort (HR 5.647; 95% CI, 1.323 to 12.048; p=0.019). Kaplan-Meier analysis indicated that the EXT1-positive group had a higher rate of accumulated nephrotic remission compared with the EXT1-negative group in the whole study cohort (p=0.028).ConclusionsThe EXT1-positive group exhibited a higher active index and a more favourable renal outcome than the EXT1-negative group. It would be better to recognise suspected LMN with EXT1 positivity as a potential autoimmune disease and maintain close follow-up due to its similarities with confirmed LMN.

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“…However, our case did not show any characteristic clinical findings of SLE, hypocomplementemia or specific pathological findings of lupus nephritis, such as fingerprint structure in EDDs or tubuloreticular inclusion in glomerular cells. Furthermore, immunohistochemistry for EXT1/2 was negative, and approximately 30% was detected along the capillary walls in lupus nephritis pure type V ( 20 - 23 ). However, the presence of anti-dsDNA antibody, the immunostaining pattern in the mesangial areas, and the full-house pattern of immunofluorescence findings suggest the presence of SLE/lupus nephritis type V ( 15 , 24 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-contactin 1 Antibody-associated Membranous Nephropathy in Chronic Inflammatory Demyelinating Polyneuropathy with Several Autoantibodies

Shida,

Iwakura,

Ohashi

et al. 2024

Intern. Med.

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A 50-year-old man diagnosed with anti-contactin 1 (CNTN1) antibody-associated chronic inflammatory demyelinating polyneuropathy (CIDP) was referred to our department for the evaluation of proteinuria. A kidney biopsy revealed membranous nephropathy (MN). Immunohistochemistry for CNTN1 revealed positive granular staining along the glomerular basement membrane, confirming anti-CNTN1 antibody-associated MN. Immunofluorescence showed a full-house pattern, and several autoantibodies, such as anti-nuclear antibody, anti-double-strand DNA antibody, and anti-cardiolipin antibody, were detected in the patient's serum. Although limited autoantibodies have been investigated in some of the reported cases, a variety of autoantibodies might be produced in anti-CNTN1 antibody-associated CIDP, accompanied by MN.

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Analysis of the Expression of Exostosins and Clinicopathological Features in Membranous Lupus Nephritis in a Chinese Cohort

Cited by 7 publications

References 9 publications

Glomerular Exostosin-Positivity is Associated With Disease Activity and Outcomes in Patients With Membranous Lupus Nephritis

Glomerular Exostosin-Positivity is Associated With Disease Activity and Outcomes in Patients With Membranous Lupus Nephritis

Clinical significance of exostosin 1 in confirmed and suspected lupus membranous nephropathy

Anti-contactin 1 Antibody-associated Membranous Nephropathy in Chronic Inflammatory Demyelinating Polyneuropathy with Several Autoantibodies

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