Analysis of the Expression of Cutaneous Lymphocyte-associated Antigen on the Peripheral Blood and Cutaneous Lymphocytes of Alopecia Areata Patients

Yano, Shoichiro; Nakamura, Kimie; Okochi, Hitoshi; Tamaki, Kunihiko

doi:10.1080/00015550252948077

Cited by 25 publications

(24 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Skin-infiltrating leukocytes in AA also express cutaneous lymphocyte-associated antigen (CLA), which could be an alternative marker of activated cells for targeting and blocking skin infiltration (Ref. 159). Other activated cell-surface markers and variants expressed during migration might be additional targets.…”

Section: Leukocyte Migration and Infiltration Of Skin And Hair Folliclesmentioning

confidence: 99%

Alopecia areata: pathogenesis and potential for therapy

Shapiro

et al. 2006

Expert Rev. Mol. Med.

View full text Add to dashboard Cite

Although the complete picture for alopecia areata (AA) pathogenesis has yet to be determined, recent research has made much progress in our understanding of the disease mechanism. Numerous circumstantial evidence supports the notion that AA is fundamentally a disease mediated by inflammatory cells and may be autoimmune in nature. Recent research has shown the hair-loss phenotype is precipitated predominantly by CD8+ lymphocytes, but the disease mechanism is driven by CD4+ lymphocytes. Although genetic susceptibility is a key contributor to disease development, disease onset and phenotypic presentation are probably modified by complex environmental interplay. On the basis of our current understanding of AA disease pathogenesis, several experimental and theoretical therapeutic approaches might be possible. However, the pathogenetic disease mechanism is particularly robust and the development of a cure for AA will be a significant challenge.

show abstract

Section: Leukocyte Migration and Infiltration Of Skin And Hair Folliclesmentioning

confidence: 99%

Alopecia areata: pathogenesis and potential for therapy

Shapiro

et al. 2006

Expert Rev. Mol. Med.

View full text Add to dashboard Cite

show abstract

“…Theoretically, skin resident T cells may play initial roles in AA progression. Infiltrating T cells in AA lesions strongly express CLA, CCR4, and CCR6, suggesting skin resident T cells may be active in AA pathogenesis [21,145].…”

Section: Potential Role Of Skin Resident T Cells In Alopecia Areatamentioning

confidence: 99%

The role of lymphocytes in the development and treatment of alopecia areata

Guo

Cheng

Shapiro

et al. 2015

Expert Review of Clinical Immunology

View full text Add to dashboard Cite

SummaryAlopecia areata (AA) development is associated with both innate and adaptive immune cell activation, migration to peri-and intra-follicular regions, and hair follicle disruption. Both CD4+ and CD8+ lymphocytes are abundant in AA lesions; however, CD8+ cytotoxic T lymphocytes are more likely to enter inside hair follicles, circumstantially suggesting that they have a significant role to play in AA development. Several rodent models recapitulate important features of the human autoimmune disease and demonstrate that CD8+ cytotoxic T lymphocytes are fundamentally required for AA induction and perpetuation. However, the initiating events, the selfantigens involved, and the molecular signaling pathways, all need further exploration. Studying CD8+ cytotoxic T lymphocytes and their fate decisions in AA development may reveal new and improved treatment approaches.

show abstract

“…Based on the findings that for UVB the most effective wavelength in clearing psoriasis is at 313 nm (7–9), an experimental fluorescent lamp emitting narrow-band UVB radiation with a peak of 311 ± 2 nm was developed and explored [10]. Several clinical trials confirmed the efficacy of 311 nm narrow-band UVB in phototherapy of psoriasis [11, 12, 13, 14]. Initially, the low intensity of the tubes (40 W) resulted in longer exposure times, rendering the treatment more time consuming and expensive.…”

Section: Introductionmentioning

confidence: 99%

Clinical Efficacy of Narrow-Band UVB (311 nm) Combined with Dithranol in Psoriasis

Carrozza¹,

Häusermann²,

Nestle³

et al. 2000

Dermatology

View full text Add to dashboard Cite

Background: For UVB, the most effective wavelength in clearing psoriatic lesions was found to be of 313 nm. The efficacy of whole body exposure to narrow-band UVB (311 nm) combined with dithranol in psoriasis has not been evaluated to date. Objective: Evaluation of the clinical efficacy of phototherapy with narrow-band UVB (311 nm) and dithranol for psoriasis by means of whole body exposures and analysis of the mean cumulative irradiation dose. Methods: In this open pilot study, 13 patients were treated for 4–5 weeks. Evaluation of the therapeutic efficacy was performed by comparing the Psoriasis Area and Severity Index (PASI) scores at baseline and after 4 weeks of treatment. The cumulative irradiation dose was also calculated. Results: Evaluation of the PASI scores showed a significant overall reduction of psoriatic lesions after 4 weeks of treatment. The cumulative irradiation dose was similar or lower to those found for phototherapy with narrow-band UVB alone. Discussion: In patients with widespread psoriasis, treatment with narrow-band UVB (311 nm) combined with dithranol is safe and effective, allowing reduction of the cumulative irradiation dose.

show abstract

Analysis of the Expression of Cutaneous Lymphocyte-associated Antigen on the Peripheral Blood and Cutaneous Lymphocytes of Alopecia Areata Patients

Cited by 25 publications

References 4 publications

Alopecia areata: pathogenesis and potential for therapy

Alopecia areata: pathogenesis and potential for therapy

The role of lymphocytes in the development and treatment of alopecia areata

Clinical Efficacy of Narrow-Band UVB (311 nm) Combined with Dithranol in Psoriasis

Contact Info

Product

Resources

About