Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function

Marks, Matthias; Pennimpede, Tracie; Lange, Lisette; Grote, Phillip; Herrmann, Bernhard G.; Wittler, Lars

doi:10.1016/j.gene.2015.09.035

Cited by 13 publications

(13 citation statements)

References 39 publications

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“…Although DDIAS functions as an anti-apoptotic protein in response to DNA repair and PRSS23 expression is regulated by estrogens, the other functions of these two genes remain to be elucidated ( Huan et al, 2014 ; Im et al, 2016 ). PRCP and FAM181B may participate in cold adaptation by regulating angiogenesis and nervous system development ( Hagedorn, 2011 ; Marks et al, 2016 ). In addition, ZNF536 , a gene on chromosome 11, showed strong positive selection in the CA chickens, as exhibited by the high F st CA-to-ME , π-Ratio ME/CA , and XPEHH CA-to-ME values ( Figure 5A ), while shared haplotypes were rarely observed in the CA and other chickens ( Figure 5B ).…”

Section: Resultsmentioning

confidence: 99%

Genome-wide scan for selective footprints and genes related to cold tolerance in Chantecler chickens

Xu¹,

Wei²,

Li³

et al. 2021

Zoological Research

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The Chantecler chicken, a unique Canadian indigenous breed, is well adapted to extremely cold environments. However, its genetic characteristics have not been well studied. Here, we analyzed the whole genomes of 10 Chantecler chickens and 121 worldwide chickens, which indicated that Chantecler chickens were derived from commercial chickens and exhibit a high level of inbreeding. Based on a genome-wide scan, we identified two vital candidate regions containing ME3 and ZNF536 , which are related to fat metabolism and nervous system in cold adaptation, respectively. We also found that the genetic mechanism of cold adaptation in Chantecler chickens differed from that of chickens from other cold regions, such as northern China. Our study indicated that specialized commercial chickens in the early 20th century contained sufficient genetic diversity to adapt to extreme cold environments over a very short time. These findings enrich our understanding of the adaptive potential of commercial species.

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Section: Resultsmentioning

confidence: 99%

Genome-wide scan for selective footprints and genes related to cold tolerance in Chantecler chickens

Xu¹,

Wei²,

Li³

et al. 2021

Zoological Research

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“…Some genes ( SLIT1 , TNR , FAM181B , IFT172 , PPM1G , SNX17 , and PREB ) associated with neural development [ 38 , 39 , 40 , 41 , 58 , 59 , 60 , 61 , 62 , 63 ] were also found in the top 20 significant windows for both traits. Costa et al [ 10 ] also detected genes related to neural development that were associated with reproductive traits.…”

Section: Resultsmentioning

confidence: 99%

Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows

et al. 2017

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Reproductive traits are economically important for beef cattle production; however, these traits are still a bottleneck in indicine cattle since these animals typically reach puberty at older ages when compared to taurine breeds. In addition, reproductive traits are complex phenotypes, i.e., they are controlled by both the environment and many small-effect genes involved in different pathways. In this study, we conducted genome-wide association study (GWAS) and functional analyses to identify important genes and pathways associated with heifer rebreeding (HR) and with the number of calvings at 53 months of age (NC53) in Nellore cows. A total of 142,878 and 244,311 phenotypes for HR and NC53, respectively, and 2,925 animals genotyped with the Illumina Bovine HD panel (Illumina®, San Diego, CA, USA) were used in GWAS applying the weighted single-step GBLUP (WssGBLUP) method. Several genes associated with reproductive events were detected in the 20 most important 1Mb windows for both traits. Significant pathways for HR and NC53 were associated with lipid metabolism and immune processes, respectively. MHC class II genes, detected on chromosome 23 (window 25-26Mb) for NC53, were significantly associated with pregnancy success of Nellore cows. These genes have been proved previously to be associated with reproductive traits such as mate choice in other breeds and species. Our results suggest that genes associated with the reproductive traits HR and NC53 may be involved in embryo development in mammalian species. Furthermore, some genes associated with mate choice may affect pregnancy success in Nellore cattle.

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“…Little is known about the function of FAM181 proteins; however, one study showed that, in mice, Fam181a/b are expressed in neural tissues, such as the forebrain, midbrain, hindbrain and neural tube. However, knockout of Fam181b does not result in an obvious phenotype (Marks et al, 2016). Therefore, further work is required to determine the role of FAM181A/B in development in order to determine the significance of its interaction with TEAD.…”

Section: )mentioning

confidence: 99%

TEAD family transcription factors in development and disease

2021

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The balance between stem cell potency and lineage specification entails the integration of both extrinsic and intrinsic cues, which ultimately influence gene expression through the activity of transcription factors. One example of this is provided by the Hippo signalling pathway, which plays a central role in regulating organ size during development. Hippo pathway activity is mediated by the transcriptional co-factors Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which interact with TEA domain (TEAD) proteins to regulate gene expression. Although the roles of YAP and TAZ have been intensively studied, the roles played by TEAD proteins are less well understood. Recent studies have begun to address this, revealing that TEADs regulate the balance between progenitor self-renewal and differentiation throughout various stages of development. Furthermore, it is becoming apparent that TEAD proteins interact with other co-factors that influence stem cell biology. This Primer provides an overview of the role of TEAD proteins during development, focusing on their role in Hippo signalling as well as within other developmental, homeostatic and disease contexts.

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Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function

Cited by 13 publications

References 39 publications

Genome-wide scan for selective footprints and genes related to cold tolerance in Chantecler chickens

Genome-wide scan for selective footprints and genes related to cold tolerance in Chantecler chickens

Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows

TEAD family transcription factors in development and disease

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