Analysis of the fluid biochemistry in patients with prolonged wound drainage after hip hemiarthroplasty

Canbek, Umut; Dibek, Esra; Çöl, Bekir; Canbek, Tuğba Dübektaş; Aydoğan, Nevres Hürriyet; Usmanov, N U; Kasap, Murat; Akpınar, Gürler

doi:10.1016/j.injury.2020.10.034

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…In the present era, omics studies illuminate the mechanisms of action of various compounds on cells. Studies involving natural compounds with phenolic structures provide crucial examples of this [47][48]. More comprehensive studies using molecular genetics and omics approaches could be employed to decipher the genes, proteins, and metabolites associated with the effects of benzoic acid and its derivatives on cancer cells.…”

Section: Discussionmentioning

confidence: 99%

The Cytotoxic Effect of Benzoic Acid on Ten Different Cancer Cell Lines

Öztürkel Kabakaş,

Sezer Kürkçü,

Onat Taşdelen

et al. 2024

Eskişehir Technical University Journal of Science and Technology a - Applied Sciences and Engineering

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Cancer, having numerous types, is among the most dangerous and complex chronic diseases in the world affecting the wellbeing of humans, society and economy. The exploration and reassessment of effective chemicals, compounds, and natural products as potential agents for alleviating the adverse effects of cancer and its related symptoms continue on a global scale. This process involves an initial evaluation of the cytotoxic activities of potential drug candidates or treatment regimens on diverse cancer cell types in an ex vivo context. Benzoic acid (BA), an aromatic carboxylic acid that is widely available and used in the food industry, is one of the phenolic acids that may bear considerable anti-cancer potential. It is useful to find out the comparable effect of BA on various cancer types. Therefore, in this study, we tested the cytotoxicity of BA using MTT assay, on a number of ten different cancer cell lines and one normal cell type, namely prostate cancer (PC3), cervical cancer (HeLA), liver cancer (HUH7), colon cancer (CaCO2, HT29, SW48), bone cancer (MG63 and A673), pharyngeal cancer (2A3), lung cancer (CRM612) and kidney epithelial control cell line (Phoenix), respectively. IC50 (µg/ml) values after 48 and 72-hour exposure to BA were found to differ between 85.54±3.17 to 670.6±43.26, while the IC values for the control cell line Phoenix were 410.54±32.29 and 231.16±25.25, respectively. Taking into account of statistical evaluation of the IC50 values for BA on 11 cell types, we suggest that the molecular and omics approaches can be implemented in more details in order to find cellular and biochemical targets of BA as well as elucidating molecular mode of action, especially starting with the cancer cell lines of MG63, CRM612 and A673, in which the IC50 levels are relatively the lowest compared to those of the control cell line.

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Section: Discussionmentioning

confidence: 99%

The Cytotoxic Effect of Benzoic Acid on Ten Different Cancer Cell Lines

Öztürkel Kabakaş,

Sezer Kürkçü,

Onat Taşdelen

et al. 2024

Eskişehir Technical University Journal of Science and Technology a - Applied Sciences and Engineering

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“…This founding was failed in the group of patients undergoing TKA with pre-ALB < 35 g/L due to the small sample size. However, there is no doubt that the use of drain would lead to an increased risk of HA administration because theoretically, drain use leads to the loss of proteins and nutrients while extracting the hemorrhage, which is disadvantageous to wound recovery [16]. Therefore, the use of drain during THA or TKA should be avoided or removed earlier since prolonged use is not necessary [17].…”

Section: Discussionmentioning

confidence: 99%

Incidence and Risk Factors Associated with Human Albumin Administration Following Total Joint Arthroplasty.

Zhang¹,

Si²,

Xie³

et al. 2021

Preprint

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BackgroundHuman albumin (HA) administration is associated with an increased risk of acute renal failure and most other complications in patients undergoing total hip or knee arthroplasty (THA, TKA). Therefore, it is vital to reduce the use of HA and identify risk factors for its use. This study aims to determine the incidence and risk factors of HA administration in patients undergoing THA or TKA.MethodsWe identified patients undergoing THA or TKA in multiple institutions from 2014 to 2016 and collected patient demographics and perioperative variables. The criterion of HA administration was defined as a postoperative albumin level < 32 g/L or 32 to 35 g/L for at-risk patients. We compared 14 variables between patients who received HA administration and those who did not after stratification by the preoperative albumin (pre-ALB) level. Multivariate regressions identified the independent risk factors associated with HA administration.ResultsIn total, 958 (20.3 %) of 4713 patients undergoing THA and 410 (9.7 %) of 4248 patients undergoing TKA received HA administration. In addition to pre-ALB < 35 g/L, preoperative anemia (odds ratio [OR] 2.12, P = 0.001; OR 1.39, P < 0.001) and drain use (OR 3.33, P = 0.001; OR 4.25, P < 0.001) were also independent risk factors for HA administration after THA regardless pre-ALB < 35 g/L or not, and patients undergoing TKA diagnosed of rheumatoid arthritis or ankylosing spondylitis tended to receive HA administration regardless pre-ALB < 35 g/L or not (OR 3.67, P = 0.002; OR 2.06, P < 0.001).ConclusionThe incidence of HA administration was high in patients undergoing THA or TKA, and several variables were risk factors for HA administration. This finding may aid surgeons in preoperatively identifying patients requiring HA administration and optimizing perioperative managements.

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Incidence and risk factors associated with human albumin administration following total joint arthroplasty: a multicenter retrospective study

Zhang

Xie

et al. 2021

J Orthop Surg Res

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Background Enhanced recovery after surgery (ERAS) program advocates implementation of perioperative goal-directed fluid therapy and reduced application of colloidal fluids. It should be used reasonably selectively in high-risk patients despite the clear efficacy of human albumin (HA). Therefore, it is vital to identify the risk factors for the use of HA. This study aims to determine the incidence and risk factors of HA administration in patients undergoing total hip or knee arthroplasty (THA, TKA). Methods We identified patients undergoing THA or TKA in multiple institutions from 2014 to 2016 and collected patient demographics and perioperative variables. The criterion of HA administration was defined as a postoperative albumin level < 32 g/L or 32 to 35 g/L for at-risk patients. We compared 14 variables between patients who received HA administration and those who did not after stratification by the preoperative albumin (pre-ALB) level. Multivariable regressions identified the independent risk factors associated with HA administration. Results In total, 958 (20.3%) of 4713 patients undergoing THA and 410 (9.7%) of 4248 patients undergoing TKA received HA administration. In addition to pre-ALB < 35 g/L, preoperative anemia (odds ratio [OR] 2.12, P = 0.001; OR 1.39, P < 0.001) and drain use (OR 3.33, P = 0.001; OR 4.25, P < 0.001) were also independent risk factors for HA administration after THA regardless pre-ALB < 35 g/L or not, and patients undergoing TKA diagnosed of rheumatoid arthritis or ankylosing spondylitis tended to receive HA administration regardless pre-ALB < 35 g/L or not (OR 3.67, P = 0.002; OR 2.06, P < 0.001). Conclusions The incidence of HA administration was high in patients undergoing THA or TKA, and several variables were risk factors for HA administration. This finding may aid surgeons in preoperatively identifying patients requiring HA administration and optimizing perioperative managements.

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Analysis of the fluid biochemistry in patients with prolonged wound drainage after hip hemiarthroplasty

Cited by 4 publications

References 29 publications

The Cytotoxic Effect of Benzoic Acid on Ten Different Cancer Cell Lines

The Cytotoxic Effect of Benzoic Acid on Ten Different Cancer Cell Lines

Incidence and Risk Factors Associated with Human Albumin Administration Following Total Joint Arthroplasty.

Incidence and risk factors associated with human albumin administration following total joint arthroplasty: a multicenter retrospective study

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