Analysis of the Frequency of Cardiac Arrhythmias and Conduction Disturbances From a Health-Care Perspective

Castroviejo, Eduardo Vázquez Ruiz de; Bellido, Juan Muñoz; Cabezas, Cristóbal Lozano; Moreno, Antonio Ramírez; Herrera, María Teresa; Castellani, Ada Tarabini; Pineda, Antonio Fajardo; Araque, Blas Jiménez; Lechuga, Juan B. Armenteros; Vilardebó, Carlos Pagola

doi:10.1016/s1885-5857(06)60252-1

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…These data are consistent with the estimated global rates of approximately 1-4% (Zulkifly et al, 2018). Although it may seem like a low percentage, electrical abnormalities appear in up to 39% of patients with cardiopathies (Vazquez Ruiz de Castroviejo et al, 2005). Within this population, sudden cardiac death constitutes a significant cause of mortality.…”

Section: Introductionsupporting

confidence: 88%

Mitochondrial and Sarcoplasmic Reticulum Interconnection in Cardiac Arrhythmia

Salazar-Ramírez

Ramos-Mondragón

García‐Rivas

2021

Front. Cell Dev. Biol.

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Ca2+ plays a pivotal role in mitochondrial energy production, contraction, and apoptosis. Mitochondrial Ca2+-targeted fluorescent probes have demonstrated that mitochondria Ca2+ transients are synchronized with Ca2+ fluxes occurring in the sarcoplasmic reticulum (SR). The presence of specialized proteins tethering SR to mitochondria ensures the local Ca2+ flux between these organelles. Furthermore, communication between SR and mitochondria impacts their functionality in a bidirectional manner. Mitochondrial Ca2+ uptake through the mitochondrial Ca2+ uniplex is essential for ATP production and controlled reactive oxygen species levels for proper cellular signaling. Conversely, mitochondrial ATP ensures the proper functioning of SR Ca2+-handling proteins, which ensures that mitochondria receive an adequate supply of Ca2+. Recent evidence suggests that altered SR Ca2+ proteins, such as ryanodine receptors and the sarco/endoplasmic reticulum Ca2+ ATPase pump, play an important role in maintaining proper cardiac membrane excitability, which may be initiated and potentiated when mitochondria are dysfunctional. This recognized mitochondrial role offers the opportunity to develop new therapeutic approaches aimed at preventing cardiac arrhythmias in cardiac disease.

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Section: Introductionsupporting

confidence: 88%

Mitochondrial and Sarcoplasmic Reticulum Interconnection in Cardiac Arrhythmia

Salazar-Ramírez

Ramos-Mondragón

García‐Rivas

2021

Front. Cell Dev. Biol.

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“…Cardiac arrhythmias and conduction disturbances affect 0.1% of adults younger than 55 years old, increasing to 9% in those older than 80 years 5 – 8 . They also occur in almost 40% of patients attending cardiology outpatient clinics 7 . The onset of such conditions may be attributed to age, genetic predisposition, lifestyle, myocardial remodelling, fibrosis of tissues, and history of surgical procedures.…”

Section: Introductionmentioning

confidence: 99%

High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling

Stephenson

Atkinson

Kottas

et al. 2017

Sci Rep

104

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Cardiac arrhythmias and conduction disturbances are accompanied by structural remodelling of the specialised cardiomyocytes known collectively as the cardiac conduction system. Here, using contrast enhanced micro-computed tomography, we present, in attitudinally appropriate fashion, the first 3-dimensional representations of the cardiac conduction system within the intact human heart. We show that cardiomyocyte orientation can be extracted from these datasets at spatial resolutions approaching the single cell. These data show that commonly accepted anatomical representations are oversimplified. We have incorporated the high-resolution anatomical data into mathematical simulations of cardiac electrical depolarisation. The data presented should have multidisciplinary impact. Since the rate of depolarisation is dictated by cardiac microstructure, and the precise orientation of the cardiomyocytes, our data should improve the fidelity of mathematical models. By showing the precise 3-dimensional relationships between the cardiac conduction system and surrounding structures, we provide new insights relevant to valvar replacement surgery and ablation therapies. We also offer a practical method for investigation of remodelling in disease, and thus, virtual pathology and archiving. Such data presented as 3D images or 3D printed models, will inform discussions between medical teams and their patients, and aid the education of medical and surgical trainees.

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“…Of the five diagnoses studied in the 6-month period, cardiac arrhythmias had the highest incidence among patients with and without syncope. This result is not surprising, since cardiac arrhythmias are common in the general population, with atrial fibrillation being the most common arrhythmia [ 50 , 51 , 52 , 53 , 54 ]. However, the data we evaluated do not allow further classification of the cardiac arrhythmias diagnosed during the 6-month period.…”

Section: Discussionmentioning

confidence: 99%

Association between Syncope and the 6-Month Incidence of Ischemic Stroke, Arrhythmia, Brain Tumor, Epilepsy, and Anxiety Disorder

et al. 2023

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Objectives: the aim of the present study is to investigate the associations between syncope and subsequent diagnoses of brain tumor, cardiac arrhythmia, stroke/transient ischemic attack (TIA), epilepsy, and anxiety disorder in a large outpatient population in Germany. Methods: This retrospective cohort study uses data from the Disease Analyzer database (IQVIA). Adults who received syncope diagnosis from one of 1284 general practices between January 2005 and December 2021 (index date) were included and matched (1:1) to individuals without syncope diagnosis using a propensity score based on age, sex, the number of consultations during the follow-up period (up to 6 months), and defined co-diagnoses documented within 12 months prior to and on the index date. Finally, associations between syncope and subsequent outcome diagnoses were investigated using multivariable logistic regression models. Results: Data related to 64,016 patients with and 64,016 patients without syncope (mean age 54.5 years, 56.5% female) were available. In total, 6.43% of syncope patients and 2.14% of non-syncope patients were diagnosed with one of the five outcome diagnoses within 6 months of the index date. There was a positive and significant association between syncope and incidences of ischemic stroke/TIA (OR = 2.83, 95% CI = 2.41–3.32), arrhythmia (OR = 3.81, 95% CI = 3.44–4.18), brain tumor (OR = 4.24, 95% CI = 2.50–7.19), epilepsy (OR = 5.52, 95% CI = 4.27–7.14), and anxiety disorder (OR = 1.99, 95% CI = 1.79–2.21). Conclusions: Syncope is significantly associated with an increased risk of subsequent ischemic stroke/TIA, cardiac arrhythmia, brain tumor, epilepsy, and anxiety disorder. Nevertheless, the cumulative incidences for all five diagnoses are very low.

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Analysis of the Frequency of Cardiac Arrhythmias and Conduction Disturbances From a Health-Care Perspective

Cited by 4 publications

References 28 publications

Mitochondrial and Sarcoplasmic Reticulum Interconnection in Cardiac Arrhythmia

Mitochondrial and Sarcoplasmic Reticulum Interconnection in Cardiac Arrhythmia

High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling

Association between Syncope and the 6-Month Incidence of Ischemic Stroke, Arrhythmia, Brain Tumor, Epilepsy, and Anxiety Disorder

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