Analysis of the hematological and biochemical parameters related to lead intoxication

Yilmaz, Hınç; Keten, Alper; Karacaoğlu, Emre; Tutkun, Engın; Akçan, Ramazan

doi:10.1016/j.jflm.2012.04.001

Cited by 36 publications

(15 citation statements)

References 14 publications

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“…Searches were made on PubMed combining the terms “blood lead” and either “thyroid,” “thyroxine,” or “triiodothyronine.” The last search was made in April 3, 2014. Data from 16 studies published in journal articles were used [Robins et al, ; Cullen et al, ; Bielecka et al, ; Horiguchi et al, ; Tuppurainen et al, ; Gustafson et al, ; Gennart et al, ; Andrzejak et al, ; Schumacher et al, ; Dursun and Tutus ; López et al, ; Singh et al, ; Erfurth et al, ; Liang et al, ; Bledsoe et al, ; Yılmaz et al, ]. All the studies that were included had subjects that were exposed to lead.…”

Section: Methodsmentioning

confidence: 99%

A meta‐analysis of studies investigating the effects of occupational lead exposure on thyroid hormones

Krieg

2016

American J Industrial Med

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Introduction Investigations of the effects of occupational exposure to lead on the concentrations of thyroid hormones in the blood have not produced consistent results. A meta-analysis was performed to assess the effect of occupational exposure to lead on thyroid hormone concentrations using the results from published studies. Methods Group means from studies of the thyroid function of persons occupationally exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between thyroid hormone concentrations and log10 blood lead concentrations or duration of exposure to lead were estimated using mixed models. The hormones analyzed were thyroid stimulating hormone, total and free thyroxine, and total and free triiodothyronine. Results No differences in mean thyroid hormone concentrations were found between the exposed and control groups. No relationships were found between blood lead or the duration of exposure to lead and thyroid hormone concentrations. Conclusion The results of the analysis do not provide evidence for an effect of occupational lead exposure on thyroid function in men.

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Section: Methodsmentioning

confidence: 99%

A meta‐analysis of studies investigating the effects of occupational lead exposure on thyroid hormones

Krieg

2016

American J Industrial Med

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“…Acute lead poisoning usually presents as gastroenteritis in adults. Long-term lead exposure can cause encephalopathy, peripheral neuropathy, cognitive delays, anemia, and digestive and renal issues [ 1 , 2 ]. Chronic occupational lead poisoning is an issue in China, and unfortunately is also common in European countries and the U.S. [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Dose-Response Relationship between Cumulative Occupational Lead Exposure and the Associated Health Damages: A 20-Year Cohort Study of a Smelter in China

Huang

et al. 2016

IJERPH

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Long-term airborne lead exposure, even below official occupational limits, has been found to cause lead poisoning at higher frequencies than expected, which suggests that China’s existing occupational exposure limits should be reexamined. A retrospective cohort study was conducted on 1832 smelting workers from 1988 to 2008 in China. These were individuals who entered the plant and came into continuous contact with lead at work for longer than 3 months. The dose-response relationship between occupational cumulative lead exposure and lead poisoning, abnormal blood lead, urinary lead and erythrocyte zinc protoporphyrin (ZPP) were analyzed and the benchmark dose lower bound confidence limits (BMDLs) were calculated. Statistically significant positive correlations were found between cumulative lead dust and lead fumes exposures and workplace seniority, blood lead, urinary lead and ZPP values. A dose-response relationship was observed between cumulative lead dust or lead fumes exposure and lead poisoning (p < 0.01). The BMDLs of the cumulative occupational lead dust and fumes doses were 0.68 mg-year/m3 and 0.30 mg-year/m3 for lead poisoning, respectively. The BMDLs of workplace airborne lead concentrations associated with lead poisoning were 0.02 mg/m3 and 0.01 mg/m3 for occupational exposure lead dust and lead fume, respectively. In conclusion, BMDLs for airborne lead were lower than occupational exposure limits, suggesting that the occupational lead exposure limits need re-examination and adjustment. Occupational cumulative exposure limits (OCELs) should be established to better prevent occupational lead poisoning.

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“…In addition, Cd intoxication results in anemia in patients with Itai-Itai disease (Horiguchi et al, 1994). Exposure to Pb could result in decrease of Hb content in occupational disease patients (Yılmaz et al, 2012). In vivo studies also indicate that exposure to Cd reduced red blood cell count and hemoglobin content (Goncalves et al, 2012;Ognjanović et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Effects of lead and cadmium co-exposure on hemoglobin in a Chinese population

Xiao

Zhou

et al. 2015

Environmental Toxicology and Pharmacology

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Analysis of the hematological and biochemical parameters related to lead intoxication

Cited by 36 publications

References 14 publications

A meta‐analysis of studies investigating the effects of occupational lead exposure on thyroid hormones

A meta‐analysis of studies investigating the effects of occupational lead exposure on thyroid hormones

Dose-Response Relationship between Cumulative Occupational Lead Exposure and the Associated Health Damages: A 20-Year Cohort Study of a Smelter in China

Effects of lead and cadmium co-exposure on hemoglobin in a Chinese population

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