Analysis of the Immune Responses of Mice to Infection with<i>Leishmania braziliensis</i>

DeKrey, Gregory K.; Lima, Hermenio; Titus, Richard G.

doi:10.1128/iai.66.2.827-829.1998

Cited by 49 publications

(28 citation statements)

References 21 publications

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“…BALB/c mice were ranked as most susceptible although L. braziliensis does not produce severe or lasting cutaneous lesions in this mouse strain. The analysis of the immune response has shown that L. braziliensis-infected BALB/c mice produce less IL-4, when compared with L. major infected mice, and treating L. braziliensis-infected BALB/c mice with anti-IFN-g significantly enhanced lesion size and prevented mice from resolving the infection [6]. These authors suggest that an IFN-g-dependent mechanism is responsible for the killing of L. braziliensis in BALB/c mice and that the weak infectivity of L. braziliensis in this mouse strain might be due to the inability of the parasite to elicit a strong and sustained IL-4 production.…”

Section: In Vivo Models Tegumentary Leishmaniasismentioning

confidence: 99%

Animal models for infectious diseases caused by parasites: Leishmaniasis

Oliveira

Teixeira

Gomes

et al. 2004

Drug Discovery Today: Disease Models

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Section: In Vivo Models Tegumentary Leishmaniasismentioning

confidence: 99%

Animal models for infectious diseases caused by parasites: Leishmaniasis

Oliveira

Teixeira

Gomes

et al. 2004

Drug Discovery Today: Disease Models

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“…Few studies have been carried out to investigate the host response to infection with species of Leishmania that cause disease in the New World. All strains of mice appear to be resistant to L. braziliensis; thus, a good murine model of infection with this species of parasite is not available [12][13][14][15]. In contrast, most strains of mice are susceptible to infection with Leishmania from the mexicana complex [13,[16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Different species determine distinct profiles of immune and histopathological responses in CBA mice

Souza

Silva

et al. 2000

Microbes and Infection

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Most experimental studies on leishmaniasis compare two different inbred strains of mice that are resistant or susceptible to one species of Leishmania. In the present study we characterized some cytokines and nitric oxide production as well as histological changes related to resistance and susceptibility in isogenic CBA mice infected with Leishmania major or Leishmania amazonensis. CBA mice are capable of controlling infection with L. major, but they succumb to infection with L. amazonensis. Cells from susceptible L. amazonensis-infected CBA mice produced interleukin (IL)-4 and IL-10 but no interferon (IFN)-gamma. On the other hand, resistant L. major-infected CBA mice produced IFN-gamma and IL-10, but IL-4 was detected only in the first week of infection. Histopathological studies showed patterns of tissue responses at the site of the infection and in the draining lymph nodes that correlated with resistance or susceptibility. Resistant mice showed a mixed inflammatory cell infiltration and granulomas in the lesions, whereas in susceptible mice only heavily parasitized macrophages were seen. Our results indicate an important role of the parasite species in determining the pattern of immune response. L. amazonensis induces a Th2-type immune response, whereas L. major induces a Th1-type response. These factors must be identified and taken into account in the strategies for the development of vaccines against leishmaniasis. The model presented here will be useful for the study of such factors.

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“…flaviscutellata SGH groups. It has been well documented that L. (V.) braziliensis causes a mild infection in BALB/c mice with the presence of a few infected macrophages, neutrophils and high numbers of lymphocytes (DeKrey et al 1998;Maioli et al 2004), ultimately resulting in parasite destruction. Moreover, selfhealing lesions are frequently noted (Donnelly et al 1998;de Moura et al 2005), as demonstrated in the present study.…”

Section: Discussionmentioning

confidence: 99%

Salivary gland homogenates from wild‐caught sand flies Lutzomyia flaviscutellata and Lutzomyia (Psychodopygus) complexus showed inhibitory effects on Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis infection in BALB/c mice

Francesquini

Sílveira

Passero

et al. 2014

Int J Experimental Path

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During the natural transmission of Leishmania parasites, the infected sand fly female regurgitates promastigotes into the host's skin together with its saliva. It has been reported that vector saliva contains immunomodulatory molecules that facilitate the establishment of infection. Thus, the main objective of this study was to evaluate the specificity of Lutzomyia (Lu.) flaviscutellata and Lu. (Psychodopygus) complexus salivas on the infectivity of Leishmania (L.) (Leishmania) amazonensis and L. (Viannia) braziliensis, respectively. BALB/c mice were inoculated into the skin of hind footpad with L. (L.) amazonensis and L. (V.) braziliensis promastigotes in the absence or presence of Lu. flaviscutellata and Lu. (P.) complexus salivary gland homogenates (SGHs). The evolution of the infection was evaluated by lesion size, histopathological analysis and determination of the parasite load in the skin biopsies collected from the site of infection at 4 and 8 weeks PI. The lesion size and the parasite load of both groups of mice infected in the presence of SGHs were smaller than the control groups. The histopathological features showed that the inflammatory reaction was less prominent in the groups of mice infected in the presence of both SGHs when compared to the control group. The results showed that the presence of SGHs of Lu. flaviscutellata and Lu. (P.) complexus led to induction of processes that were disadvantageous to parasite establishment during infection by L. (L.) amazonensis and L. (V.) braziliensis. An inhibitory effect on Leishmania infection could be observed in both groups inoculated with SGHs, especially when the SGH from Lu. (P.) complexus was used.

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Analysis of the Immune Responses of Mice to Infection withLeishmania braziliensis

Cited by 49 publications

References 21 publications

Animal models for infectious diseases caused by parasites: Leishmaniasis

Animal models for infectious diseases caused by parasites: Leishmaniasis

Different species determine distinct profiles of immune and histopathological responses in CBA mice

Salivary gland homogenates from wild‐caught sand flies Lutzomyia flaviscutellata and Lutzomyia (Psychodopygus) complexus showed inhibitory effects on Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis infection in BALB/c mice

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