Analysis of the impact of the body mass index in patients with gastric carcinoma

Nozoe, Tetsuo; Kohno, Mayuko; Iguchi, Tomohiro; Mori, Emiko; Maeda, Takashi; Matsukuma, Akito; Ezaki, Takahiro

doi:10.1007/s00595-012-0183-z

Cited by 16 publications

(18 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present observation that underweight gastric cancer patients experience poor survival is similar to that of several other studies 27, 28. In the Japanese population, lower BMI has been observed to be associated with an increased risk of mortality among gastric cancer patients, with a linear inverse association 27 .…”

Section: Discussionsupporting

confidence: 91%

Demographic and lifestyle factors and survival among patients with esophageal and gastric cancer: The Biobank Japan Project

Okada

Ukawa

Nakamura

et al. 2017

Journal of Epidemiology

View full text Add to dashboard Cite

BackgroundSeveral studies have evaluated associations between the characteristics of patients with esophageal and gastric cancer and survival, but these associations remain unclear. We described the distribution of demographic and lifestyle factors among patients with esophageal and gastric cancer in Japan, and investigated their potential effects on survival.MethodsBetween 2003 and 2007, 24- to 95-year-old Japanese patients with esophageal and gastric cancer were enrolled in the BioBank Japan Project. The analysis included 365 patients with esophageal squamous cell carcinoma (ESCC) and 1574 patients with gastric cancer. Hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality were estimated using medical institution-stratified Cox proportional hazards models.ResultsDuring follow-up, 213 patients with ESCC (median follow-up, 4.4 years) and 603 patients with gastric cancer (median follow-up, 6.1 years) died. Among patients with ESCC, the mortality risk was higher in ever drinkers versus never drinkers (multivariable HR = 2.37, 95% CI: 1.24, 4.53). Among patients with gastric cancer, the mortality risk was higher in underweight patients versus patients of normal weight (multivariable HR = 1.66, 95% CI: 1.34, 2.05). Compared to patients with gastric cancer with no physical exercise habit, those who exercised ≥3 times/week had a lower mortality risk (multivariate HR = 0.75, 95% CI = 0.61, 0.93). However, lack of stage in many cases was a limitation.ConclusionsAmong patients with ESCC, alcohol drinkers have a poor prognosis. Patients with gastric cancer who are underweight also have a poor prognosis, whereas patients with physical exercise habits have a good prognosis.

show abstract

Section: Discussionsupporting

confidence: 91%

Demographic and lifestyle factors and survival among patients with esophageal and gastric cancer: The Biobank Japan Project

Okada

Ukawa

Nakamura

et al. 2017

Journal of Epidemiology

View full text Add to dashboard Cite

show abstract

“…In any case, diminished nutritional status may worsen the prognosis of any patient with a serious illness, including gastric cancer. The association between BMI and long-term outcome has been investigated with regard to certain malignancies (43,44), including a number of controversial studies evaluating BMI and GC prognosis (23)(24)(25)(26)(27)(28). In the present study, preoperative and postoperative BMI of patients with stage II/III GC were evaluated, although no association between BMI and survival rates was identified.…”

Section: Discussionmentioning

confidence: 99%

“…Of these, the preoperative prognostic nutritional index (PNI) as a reflection of the immunological and nutritional condition of the patients has been associated with the outcomes of patients who undergo gastrectomy for a number of stages of GC (10,11,16,17). Although the association between body mass index (BMI) and postoperative complications has been investigated (18)(19)(20)(21)(22), the association between BMI and long-term survival subsequent to curative gastrectomy remains unclear (23)(24)(25)(26)(27)(28) In the present study, the dose-response effects of S-1 ACT on survival in patients who received gastrectomy for GC were clarified, and other clinical factors that affected their survival were analyzed, including BMI and PNI as nutritional parameters.…”

Section: Introductionmentioning

confidence: 99%

Outcome predictors for patients with stage II/III gastric cancer who undergo gastrectomy and S-1 adjuvant chemotherapy

et al. 2017

View full text Add to dashboard Cite

Abstract. Predictors of survival in patients with stage II/III gastric cancer (GC) who received tegafur/gimeracil/oteracil (S-1) adjuvant chemotherapy (ACT) subsequent to gastrectomy were examined. Additionally, the association between dose intensity of S-1 and survival rate was investigated. A total of 62 patients with stage II/III gastric cancer were retrospectively evaluated, each of whom had received a curative D2 gastrectomy and S-1 ACT. The relative performance (RP; administered/planned S-1 doses x100%), body mass index (BMI), prognostic nutritional index (PNI) and body weight (BW) were calculated, and the association of survival with these factors and other clinicopathological parameters was examined. The 1-year treatment continuation rate for S-1 was 94.2%, excluding patients who experienced cancer recurrences during their ACT year. The initial S-1 reduction rate was 38.7%. Patients with stage II/IIIA disease exhibited significantly improved 5-year overall survival rates compared with patients with stage IIIB GC, 81.6/73.7 vs. 33.8% (P<0.01). No association between RP and survival was observed. BMI, BW and PNI were significantly decreased following surgery compared with preoperative states. In the univariate analysis, postoperative BW loss (BMI loss), pathological stage and >7 lymph node metastases were significantly associated with outcome (P<0.05); in the multivariate analysis, postoperative BW loss >10.6% and pathological stages were independent prognostic factors for survival. Continuing S-1 ACT for the full year exhibited a greater effect on survival compared with dosage. Early postoperative nutritional deterioration may decrease the survival rates in these patients.

show abstract

“…For example, the N2 and N3 regional lymph nodes lie deep within the fatty mesentery around the major abdominal vessels which hampered complete removal in overweight patients (14,29). So extensive lymph node dissections on overweight patients have often been unsuccessful and the number of resected or retrieved lymph nodes (an indicator of adequacy of lymphadenectomy) was significantly smaller for the obese patient group (13,19,25,29). The presence of excessive subcutaneous fat predisposed the obese to impaired wound healing and thus wound infections and anastomotic leakage (32).…”

mentioning

confidence: 99%

Does Overweight Affect Outcomes in Patients Undergoing Gastrectomy for Cancer? A Meta-analysis of 25 Cohort Studies

Chu

et al. 2014

Japanese Journal of Clinical Oncology

View full text Add to dashboard Cite

Objective: Overweight was regarded as one of the risk factors for poor outcome after gastrectomy, but its influence on the surgical and postoperative outcomes of gastrectomy was unclear. Methods: Comprehensive searches were conducted to include cohort studies which evaluated the influence of overweight on the surgical and postoperative outcomes of gastrectomy. Data was analyzed by RevMan 5.0. Results: Twenty-five cohort studies (18 518

show abstract

Analysis of the impact of the body mass index in patients with gastric carcinoma

Abstract: BMI might be a representation of the physical condition brought about by the extent of tumor progression rather than a factor influencing the factors related to gastric carcinoma.

Cited by 16 publications

References 18 publications

Demographic and lifestyle factors and survival among patients with esophageal and gastric cancer: The Biobank Japan Project

Demographic and lifestyle factors and survival among patients with esophageal and gastric cancer: The Biobank Japan Project

Outcome predictors for patients with stage II/III gastric cancer who undergo gastrectomy and S-1 adjuvant chemotherapy

Does Overweight Affect Outcomes in Patients Undergoing Gastrectomy for Cancer? A Meta-analysis of 25 Cohort Studies

Contact Info

Product

Resources

About