Analysis of the Incidence of Euthyroid Sick Syndrome in Comprehensive Intensive Care Units and Related Risk Factors

Guo, Jianying; Hong, Yan‐Yan; Wang, Zhiyong; Li, Yukun

doi:10.3389/fendo.2021.656641

Cited by 22 publications

(15 citation statements)

References 30 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nonthyroidal illness syndrome (NTI) or euthyroid sick syndrome refers to a group of patients with serious diseases other than thyroid disorders who have abnormal thyroid hormone levels (21). However, during the course of their COVID-19 infection, 48.6% (70/144) of the patients in our study had lower-than-normal TSH levels, which may not be entirely explained by NTI.…”

Section: Discussionmentioning

confidence: 73%

Spectrum of Thyroid Illness in COVID-19

Jabeen¹,

Sidhwani²,

Rehan³

et al. 2022

PJMHS

View full text Add to dashboard Cite

Background: De novo thyroid dysfunction can occur as a result of COVID-1. Patients have diverse manifestations of thyroid illness, ranging from asymptomatic hyperthyroidism to secondary hyperthyroidism. Aim: To evaluate various thyroid diseases and compare them to mortality and clinicopathological features. Methods: After approval from the institutional ethical review board, this observational cross sectional study was carried out at a private sector hospital in Karachi. Patients diagnosed with COVID-19 admitted between December 2020 to May 2021 were recruited using consecutive sampling. Patients who did not give informed consent and had known thyroid disorders or history of thyroidectomy were excluded. To analyse the relationship between thyroid laboratory reports, and clinicopathological features, the Chi-square test and “Fischer's exact test” were utilised. SPSS version 21 was used for statistical analysis. A statistically significant P value of 0.05 was used. Results: Majority of the patients 105(72.9%) had higher FT3 levels and none of them reported with the decreased levels. 88(61.1%) came up with the higher FT4 levels while 9(6.3%) reported with decreased FT4. 9(6.3%) and 6(4.2%) were positive for the anti-thyroperoxidase and anti-thyroglobulin antibodies. The results showed statistical significance for free FT4 (p value 0.018), anti-TG (p-value 0.001) and anti-TP antibodies (p value 0.005). Conclusion: COVID-19 patients had a high frequency of thyroid abnormalities. Thyroid dysfunction appears to fluctuate over time and to recover slowly and naturally. Key words: TSH, Thyroid, COVID-19, Anti-thyroglobulin, Anti-Thyroperoxidase, FT4, FT3

show abstract

Section: Discussionmentioning

confidence: 73%

Spectrum of Thyroid Illness in COVID-19

Jabeen¹,

Sidhwani²,

Rehan³

et al. 2022

PJMHS

View full text Add to dashboard Cite

show abstract

“…In the present study, qSOFA scores, the presence of hypotension, and PCT levels were all significantly associated with mortality in both entire group and geriatric population. Similarly, these variables are also shown as important predictors of mortality in patients with septic shock in published data (5).…”

Section: Discussionmentioning

confidence: 81%

“…The prevalence of ESS has been documented as a prognostic risk factor particularly in patients with severe/critical diseases. ESS is also associated with prolonged ICU stay, end stage organ dysfunction, poor prognosis and mortality (5). The prevalence of ESS is significantly higher in geriatric patients particularly with comorbid chronic diseases or malignancies (6).…”

Section: Introductionmentioning

confidence: 99%

Euthyroid Sick Syndrome: Prevalence and Prognosis in Elderly Patients With Sepsis

Cakmak¹,

Atıcı²,

Bektaş³

et al. 2022

jmed

View full text Add to dashboard Cite

Objective: Euthyroid sick syndrome (ESS) manifests by the decreased level of serum free thyroid hormones and with the normal or decreased secretion of thyroid-stimulating hormone. The study aims to identify the prevalence of ESS in elderly patients with sepsis and evaluate its possible effect on prognosis and mortality.Material and Methods: Two hundred and three patients diagnosed with sepsis were prospectively evaluated. They were divided into two groups, a geriatric group (≥65 years), and a control group (<65 years). Patients with low free T3 (fT3) and/or free T4 (fT4) were considered to have euthyroid-sick syndrome. The demographic characteristics, comorbidities, laboratory results, hospitalization data, intensive care unit (ICU) duration, treatment outcomes, and mortality rates of the patients were recorded and compared.Euthyroid sick syndrome: prevalence and prognosis in sepsis İstanbul Tıp Fakültesi Dergisi • J Ist Faculty Med Conclusions: The higher prevalence of ESS (88.5%) in elderly patients with sepsis was clearly demonstrated. Additionally, approximately two-fold higher mortality and ICU stay risk was documented in the ESS (+) group. Thus, simply screening of ESS in septic elderly patients will certainly contribute to treatment decisions and early prediction of complicated clinical course and poor prognosis.

show abstract

“…According to Guo et al, 38 B-types natriuretic peptide, platelet, and albumin are independent risk factors for NTIS. The decrease in T4 to T3 conversion is related to the reduction in albumin levels.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Nonthyroidal Illness Syndrome with Extubation Outcome in Mechanically Ventilated Children: A Prospective Cohort Study

Abdelaziz

Romih

Ismail

et al. 2022

J Pediatr Intensive Care

View full text Add to dashboard Cite

This study aimed to assess the relationship between non-thyroidal illness syndrome (NTIS) and extubation outcomes in pediatric patients requiring mechanical ventilation. This prospective cohort study included 59 patients who underwent mechanical ventilation in the pediatric intensive care unit of a tertiary care university hospital from July 2020 to June 2021. Each patient underwent laboratory testing including serum levels of thyroid-stimulating hormone (TSH), free T3 (fT3), free T4 (fT4), and reverse T3 (rT3) on the first and third days of mechanical ventilation. On the first day of mechanical ventilation, 62.7% of patients had low fT3, which significantly increased to 78% of patients on the third day. In comparison to values on day one, median levels of fT3 and fT4 significantly decreased and rT3 significantly increased on day three. However, no significant differences were found in the median TSH levels over the same time span. Thirty-five patients (59%) survived while 24 patients (41%) did not survive. Compared with survivors, non-survivors had significantly higher median serum TSH levels on day one, while all other thyroid function tests assays did not significantly differ between days one and three. Of note, serum TSH, fT3, fT4, and rT3 levels, on the first and third days, did not differ significantly between patients who experienced extubation failure and extubation success. To the best of our knowledge, this is the first study to examine thyroid function values in mechanically ventilated children to determine their correlation with extubation outcomes. In this study, NTIS did not correlate with extubation outcomes in critically ill children undergoing mechanical ventilation.

show abstract

Analysis of the Incidence of Euthyroid Sick Syndrome in Comprehensive Intensive Care Units and Related Risk Factors

Cited by 22 publications

References 30 publications

Spectrum of Thyroid Illness in COVID-19

Spectrum of Thyroid Illness in COVID-19

Euthyroid Sick Syndrome: Prevalence and Prognosis in Elderly Patients With Sepsis

Correlation of Nonthyroidal Illness Syndrome with Extubation Outcome in Mechanically Ventilated Children: A Prospective Cohort Study

Contact Info

Product

Resources

About