Analysis of the Incidence of Rheumatic Diseases in the Arkhangelsk Region: Trends in the 2010–2015 Statistical Characteristics

Титова, Л. В.; Макарова, М. В.

doi:10.14412/1995-4484-2017-521-525

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…Так, за период 2010-2014 гг. прирост общей заболеваемости ОА составил 13,7% (с 3182,1 до 3618,2 случая на 1 000 000 взрослого населения соответственно) [4]. Этот рост связан со старением населения, поскольку стандартизованные показатели заболеваемости ОА на 1000 населения в 2014 г. составляли 31,8; в 2015 г.-30,1; а в 2016 г.…”

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Orthvoltage X-Ray Therapy for the Treatment of 0-2 Gonarthritis Stages: Longterm Results of a Randomized Trial. The Dynamics of a Pain Syndrome

Макарова

Титова

Valkov

2019

Lučevaâ diagn. ter.

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The aim of the study was the comparative analysis of treatment for gonarthritis of 0–2 stages by symptomatic therapy (Symptomatic slow acting drugs for osteoarthritis — SYSADOA) and in combination with orthovoltage x-ray therapy (OVRT) within an open randomized study.Material and methods. The study included patients with clinically confirmed gonarthritis. Patients were randomly divided into 2 groups, each of them was administered a combined SYSADOA glucosamine (500 mg) and chondroitin (400 mg) sulfate, OVRT was prescribed to patients of second group. OVRT was performed on X-ray machine Xstrahl-200, a single dose was 0,45 Gy, in 10 sessions to a total dose of 4,5 Gy. The pain syndrome was evaluated by VAS, WOMAC scales, efficiency of the treatment by OARSI/OMERACT (reduction of VAS and WOMAC by more than 20% of the baseline). Disability and the number of endoprosthesis replacement were also analyzed. Evaluation was performed before, after treatment, 6, 12 and 36 months.Results. There were selected 300 patients, 150 in each group, eight people were lost. By the end of the treatment there were no statistically significant differences in the reduction of pain syndrome evaluating by VAS and WOMAC A. After 6–36 months degree of pain reduction was significantly higher in the OVRT group. After three years in the OVRT group, WOMAC A levels, VAS, VAS 20%, WOMAC A 20% were 21,9, 21,2, 69%, 78%, in the SYSADOA group 53,5, 54,9, 25%, 32%, p<0,0001. In the SYSADOA group, by the end of follow-up, 48 (32,9%) patients had a disability group, 42 (28,8%) underwent endoprosthesis replacement, in the combined treatment group — four and four cases (2,7%), respectively, p<0,0001.Conclusion: there was stable reduction of pain syndrome level among patients underwent OVRT, and improvement of the functional state of the joint, which allows to reduce the frequency of disability and knee endoprosthesis replacement.

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Orthvoltage X-Ray Therapy for the Treatment of 0-2 Gonarthritis Stages: Longterm Results of a Randomized Trial. The Dynamics of a Pain Syndrome

Макарова

Титова

Valkov

2019

Lučevaâ diagn. ter.

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“…Однако установлены статистически значимые вариации трендов первичной заболеваемости, существенно отличающиеся друг от друга по направленности и временным точкам их излома в РФ, СЗФО и АО. При общей тенденции старения населения РФ и повышения риска ОА только вследствие этого [22] отмечались периоды статистически значимого снижения уровней первичной заболеваемости.…”

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Segmented analysis of official statistical indicators dynamic series for osteoarthritis in 1994–2018 in Russia, the North-Western Federal district and the Arkhangelsk region

Макарова

Valkov

2021

Naučno-praktičeskaâ revmatologiâ

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To improve the rheumatology service in the Russian Federation, it is necessary to determine the true extent of primary and general incidence of osteoarthritis (OA).The aim of the study is a detailed assessment of trends in the dynamics of OA incidence in the Russian Federation, the North-Western Federal district (NWFD) and the Arkhangelsk region (AR).Materials and methods. We evaluated trends in the dynamics of both incidence and prevalence of OA in the Russian Federation (RF), NWFD and AR in the period 1994–2018 based on data from the annual statistical reports of the Ministry of health of the Russian Federation (form 12). Data on the population of AR were obtained in the regional Bureau of statistics – Archangelskstat, for the northwestern Federal district and the Russian Federation from freely available statistical collections of Rosstat. We analyzed the indicators of the adult population (over 18 years old). To evaluate time trends, we used segmented analysis using the Joinpoint Regression Program (National Cancer Institute, USA) to analyze linear trends, evaluate their statistical significance, and identify time points of their change (joinpoints).Results. In the period from 2004 to 2012 in Russia was a decline in the number of annually detected cases of OA, the prevalence of OA increased steadily in the 2016 year recorded a decline in the number of cases of OA in NWFD and AR. The analysis showed a discrepancy in the trends of incidence of OA in the Russian Federation, the northwestern Federal district and AR, which was nonlinear and chaotic. In all territories, the prevalence was increasing. In the Russian Federation, the period from 2004 to 2008, when the primary incidence of OA fell sharply, was marked by a stable increase in the prevalence from 2041.6 to 3383.3 per 100 thousand population. Conclusion. Analysis of official statistical information on the both incidence and prevalence of OA shows a significant variation in indicators, their fluctuations are not related to changes in the practice of diagnosis and treatment of this disease and, most likely, are associated with gaps in its accounting. Improving the epidemiological assessment of OA is possible with the introduction of a system of personalized patient registration-the osteoarthritis registry.

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“…в настоящее время диагноз «туляремия» устанавливается в первые дни обра-щения за медицинской помощью не более чем у 40-45 % больных. в структуре диагнозов при об-ращении к врачу отмечены: лимфаденит, лихорадка неясного генеза, ангина, пневмония, орз, орви, бронхит, инфекционный мононуклеоз, фурункулез, менингит, энцефалит, полинейропатия, иерсини-оз, геморрагический васкулит, узловатая эритема, конъюнктивит, грипп, острая кишечная инфекция, укус насекомого [1,6].…”

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“…анализ лечения больных в архангельской области в последние годы показал, что только 10-13 % больных получали эффектив-ную стартовую терапию антибиотиками из групп аминогликозидов, тетрациклинов или фторхиноло-нов. иногда пациента лечили до двух месяцев и про-писывали до 7 курсов различных антибиотиков [6]. назначение бета-лактамных антибиотиков (пени-циллины, цефалоспорины, карбапенемы и монобак-тамы) обычно малоэффективно, так как микроб об-ладает бета-лактамазной активностью.…”

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Epidemiological and Epizootiological Analysis of the Situation on Tularemia in the Russian Federation in 2016 and Forecast for 2017

Кудрявцева¹,

Попов²,

Мокриевич³

et al. 2017

Problemy Osobo Opasnykh Infektsii

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на территории россии в последние десятилетия туляремия проявляется спорадической заболеваемо-стью (от 50 до 150 случаев в год) и эпидемическими вспышками. динамика заболеваемости туляремией за [2006][2007][2008][2009][2010][2011][2012][2013][2014][2015][2016] на территории российской Федерации в 2016 г. зарегистрировано 123 случая инфицирования че-ловека Francisella tularensis, 90 % из них приходится на три федеральных округа: северо-западный, сибирский и центральный. эпизоотические проявления инфекции различной степени интенсивности выявлены в 56 регионах. значительное число больных туляремией наблюдалось в республике карелия, ненецком автономном округе, омской и рязанской областях, санкт-петербурге. обращают на себя внимание некоторые современные особенности проявления туляремии: неспецифичность клинических симптомов, особенно на ранних стадиях заболевания, их разнообразие возрастает при наблюдающих-ся в последнее время случаях микст-инфицирования возбудителями туляремии и других природно-очаговых инфекций. наиболее выраженными симптомами болезни являются лихорадка и лимфаденит; диагноз «туляремия» устанавливается в первые дни обращения за медицинской помощью у 40-45 % за-болевших. на основании анализа данных о заболеваемости людей, эпизоотологическом состоянии при-родных очагов туляремии, числе выделенных культур возбудителя, численности основных носителей и переносчиков, а также с учетом объемов вакцинопрофилактики в регионах определены территории, на которых наиболее вероятны эпидемические осложнения в 2017 г.Ключевые слова: туляремия, Francisella tularensis, природные очаги, эпидемическая ситуация, эпи-зоотическая ситуация. 123 cases of human infection with Francisella tularensis were registered in the territory of the Russian Federation in 2016. 90 % of the total number was reported by three Federal Districts: North-Western, Siberian, and Central ones. Epizootic manifestations of varying intensity were detected in 56 regions. A considerable number of tularemia cases were observed in the Republic of Karelia, Nenets Autonomous District, Omsk and Ryazan Regions, and in Saint-Petersburg. Conspicuous are some recent peculiarities of tularemia manifestations: non-specificity of clinical symptoms, especially at early stages of the disease, their increasing variability against the background of mixed infections with tularemia and other natural-focal infections agents. The most expressed symptoms are fever and lymphatic adenitis; the patients are diagnosed with tularemia during initial days of the sought treatment in 40-45 % of the cases. Based on the data on morbidity rates in humans, epizootiological condition of natural tularemia foci, the numbers of isolated cultures and incidence of the vectors and carriers of the agent, as well as taking into consideration the scope of preventive vaccination in the regions, identified were the territories in which epidemic complication are most likely to occur in 2017.

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Analysis of the Incidence of Rheumatic Diseases in the Arkhangelsk Region: Trends in the 2010–2015 Statistical Characteristics

Cited by 4 publications

References 9 publications

Orthvoltage X-Ray Therapy for the Treatment of 0-2 Gonarthritis Stages: Longterm Results of a Randomized Trial. The Dynamics of a Pain Syndrome

Orthvoltage X-Ray Therapy for the Treatment of 0-2 Gonarthritis Stages: Longterm Results of a Randomized Trial. The Dynamics of a Pain Syndrome

Segmented analysis of official statistical indicators dynamic series for osteoarthritis in 1994–2018 in Russia, the North-Western Federal district and the Arkhangelsk region

Epidemiological and Epizootiological Analysis of the Situation on Tularemia in the Russian Federation in 2016 and Forecast for 2017

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