Analysis of the Increase in Bone Mineral Density After Surgical Treatment of Primary Hyperparathyroidism

Mendoza‐Moreno, Fernando; Díez‐Alonso, Manuel; Ovejero-Merino, Enrique; Sánchez-Gollarte, Ana; Alvarado-Hurtado, Ricardo; Matías‐García, Belén; Rodríguez-Pascual, Ángel; Medina-Reinoso, Carlos; Ratia-Jiménez, Tomás; Hernández-Merlo, Francisco; Granell-Vicent, Javier

doi:10.1016/j.jocd.2018.11.001

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…At the LS, reported average BMD change at 1 year ranges from 2.3%, 20 2.5%, 12 4.03%, 16 6.63%, 11 8.2% 14 to as high as 12% 15,19 . Similarly, average first‐year BMD change at the FN has ranged from 1.3%, 20 2.1%, 12 3.19%, 11 3.94% 16 to 5.9% 14 . Data on TH BMD are limited, yet highly variable ranging from 0.4%, 20 1.9% 12 to 2.4% 16 .…”

Section: Discussionmentioning

confidence: 99%

“…10 However, the absolute change in BMD and its predictors have been highly variable amongst the study cohorts. [10][11][12][13][14][15][16][17][18][19][20] Besides, most of these studies have been conducted on Western PHPT patients and similar data on indigenous patients are scarce. Hence, we conducted the present study to evaluate the absolute change in BMD after curative surgery in native PHPT patients and dissect out the possible pre-and post-operative variables that might help predict the same.…”

Section: Introductionmentioning

confidence: 99%

“…Curative parathyroidectomy has long been known to improve BMD and reduce incident fracture risk in PHPT 10 . However, the absolute change in BMD and its predictors have been highly variable amongst the study cohorts 10‐20 . Besides, most of these studies have been conducted on Western PHPT patients and similar data on indigenous patients are scarce.…”

Section: Introductionmentioning

confidence: 99%

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Weight gain after curative parathyroidectomy predicts increase in bone mineral density in patients with symptomatic primary hyperparathyroidism

Pal

Arya

Aggarwal

et al. 2020

Clinical Endocrinology

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Background Primary hyperparathyroidism (PHPT) results in reduction of bone mineral density (BMD) and an increased risk of pathological fractures. Curative surgery does improve BMD; however, the magnitude of rise and predictive factors are highly variable amongst the hitherto available studies. Objectives To quantify the magnitude of improvement in BMD after curative surgery in patients with symptomatic PHPT and dissect out the possible clinical and biochemical parameters predicting the BMD rise. Methods We conducted a retrospective study of symptomatic PHPT patients undergoing surgery between August 2016 and July 2018. Patients achieving biochemical cure with pre‐ and post‐operative (at least 1 year after surgery) dual‐energy X‐ray absorptiometry scans performed were included in the study. Results After exclusion, 63 patients were included in the study (M:F = 2:5; mean age = 44.8 years). At a median interval of 15 months, the median per cent change in BMD (ΔBMD) at lumbar spine (LS), total hip (TH), femoral neck (FN) and one‐third distal radius (forearm) was 6.5%, 7.0%, 8.1% and 6.9%, respectively. Following multiple linear regression analysis, baseline BMD was found to inversely predict ΔBMD at LS, TH and forearm. Pre‐operative iPTH positively predicted ΔBMD at LS and FN. Interestingly, 82.5% of the patients had a gain in body weight following curative surgery and change in body weight emerged as a significant positive predictor of ΔBMD at all sites. Conclusions Curative surgery improves BMD at all sites in patients with symptomatic PHPT. Weight gain following surgery can be used as a positive clinical predictor of BMD rise.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Weight gain after curative parathyroidectomy predicts increase in bone mineral density in patients with symptomatic primary hyperparathyroidism

Pal

Arya

Aggarwal

et al. 2020

Clinical Endocrinology

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“…In the etiology of the secondary OP, only pHPT is the one to which OP itself is indicated for surgery [21]. In a study conducted by Mendoza-Moreno et al [22], it was shown that BMD was increased after surgery in 228 pHPT patients. Therefore, it is important to determine the parameters that determine OP in patients who are clinically followed.…”

Section: Variablementioning

confidence: 99%

CTRP3 is Significantly Decreased in Patients with Primary Hyperparathyroidism and Closely Related with Osteoporosis

Demirtaş

Acibucu

Baylan

et al. 2019

Exp Clin Endocrinol Diabetes

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Background Adipokines derived from adipocytes are one of the important factors that act as circulating regulators of bone metabolism. Complement C1q/tumor necrosis factor-related protein-3 (CTRP3), a paralog of adiponectin, is are member of the CTRP superfamily. The aim of this study was to investigate the role of serum CTRP3 in the development of osteoporosis in patients with primary hyperparathyroidism. Methods This study included 53 patients with diagnosed primary hyperparathyroidism and 30 healthy controls. Laboratory tests for the diagnosis of primary hyperparathyroidism and serum levels of CTRP3 measured for all patients. Bone mineral density was obtained on lumbar spine 1 and 4 by dual energy X-ray absorptiometry. Results Serum CTRP3 levels were lower in patients with primary hyperparathyroidism than in the control group (p<0.001). In addition, primary hyperparathyroidism patients are were divided into two groups as, with and without osteoporosis; the levels of CTRP3 were lower in patients with osteoporosis than in patients without osteoporosis (p=0.004). In logistic regression analysis, only CTRP3 levels independently determined the patients to be osteoporosis (p<0.05). According to this analysis, decreased CTRP3 (per 1 ng/mL) levels were found to increase the risk of patients for osteoporosis by 6.9%. When the CTRP3 cut-off values were taken as 30 ng/mL, it determined osteoporosis with 76.4% sensitivity and 73.2% specificity. CTRP3 and urine calcium levels were independently associated with T score in dual energy X-ray absorptiometry. Conclusions CTRP3 levels were significantly decreased in patients with primary hyperparathyroidism, and it is also related to osteoporosis.

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Solar irradiance forecasting based on direct explainable neural network

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Zhou

et al. 2020

Energy Conversion and Management

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Analysis of the Increase in Bone Mineral Density After Surgical Treatment of Primary Hyperparathyroidism

Cited by 4 publications

References 17 publications

Weight gain after curative parathyroidectomy predicts increase in bone mineral density in patients with symptomatic primary hyperparathyroidism

Weight gain after curative parathyroidectomy predicts increase in bone mineral density in patients with symptomatic primary hyperparathyroidism

CTRP3 is Significantly Decreased in Patients with Primary Hyperparathyroidism and Closely Related with Osteoporosis

Solar irradiance forecasting based on direct explainable neural network

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