To mitigate the impact of foundation pit construction on adjacent existing structures, grouting reinforcement techniques are often employed to enhance the deformation strength of the soil. This study focuses on the expansion project of the Dayun Comprehensive Hub in Shenzhen, conducting full-scale numerical simulations of the excavation of deep foundation pits adjacent to existing elevated railways and examining the effects of different grouting reinforcement schemes. The results indicate that the single-row and double-row grouting schemes increased the bearing capacity of the foundation piles by 23.7% and 31.9%, respectively, significantly enhancing the structural bearing performance. After reinforcement, the maximum deformation position of the elevated bridge foundation piles shifted upward, and the settlement distribution of the cap beam became more concentrated, indicating that grouting reinforcement effectively controlled the ground settlement and the deformation of the foundation piles. Furthermore, compared to controlling the deformation of the retaining structures, grouting reinforcement was more effective in controlling ground settlement and pile deformation, highlighting its advantages in complex environments. Although the double-row grouting scheme demonstrated superior technical performance, the single-row scheme remains the preferred option considering reinforcement efficiency and economic factors.