Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300)

Puga, Fernanda; Veiga, Heloisa; Cagy, Maurício; McDowell, Kaleb; Piedade, Roberto; Ribeiro, Pedro

doi:10.1590/s0004-282x2005000200008

Cited by 11 publications

(7 citation statements)

References 20 publications

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“…Such findings can be associated to the effect of the medication, which facilitated the activation and improvement of the motor control mechanisms, by "reducing" the anxiety levels occasioned by the task situation [17]. Further justifying the result of our study, another research's did not find any significant difference in the reaction time between the bromazepam and control groups, through a visual discrimination task, also using the oddball paradigm and visuomotor task [15,26].…”

Section: Reaction Timesupporting

confidence: 66%

“…Some studies report cases of healthy subjects using this drug, with the main objective of producing cognitive improvement, especially with regards to memory and attention [14]. On the other hand, bromazepam, an anxiolytic drug with a depressive effect on the CNS, is therapeutically utilized to produce sedation, induce sleep, relieve anxiety and muscle spasms, in addition to preventing convulsions [15]. Studies prove its efficacy in treating anxiety disorder, although they highlight the drug side effects in tasks involving sensorimotor integration [16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Effects of modafinil and bromazepam on decision-making: a P300 analysis

Novaes

Bittencourt²,

Adolfo³

et al. 2015

Int Arch Med

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Drug influence on the decision making process has been scarcely studied. Researchers have driven the hypothesis that drugs might cause interference on cortical circuits. The aim of the present study is to evaluate the electrophysiological and behavioral changes occurring in the P300 after ingestion of modafinil (200mg), bromazepam (6mg) and placebo in healthy subjects exposed to a sensorimotor task based on the oddball paradigm. The sample for this study consisted of 10 subjects of both sexes, with ages ranging between 20 and 45, who were submitted to a quantitative electroencephalography. The experimental procedure was carried out in three visits, before and after drug ingestion. The results demonstrated a significant increase in the P300 latency and amplitude for the target condition, when compared to the non-target condition, for all analyzed electrodes. No significant difference was found for group or moment. A statistically significant difference was found for the group variable in the behavioral analysis. Such results suggest that the P300 is a measure, which is not sensitive to drug ingestion. On the other hand, the measure presented certain level of sensitivity when the subjects faced two different conditions in the decision making process orientation.

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Section: Reaction Timesupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Effects of modafinil and bromazepam on decision-making: a P300 analysis

Novaes

Bittencourt²,

Adolfo³

et al. 2015

Int Arch Med

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“…Bromazepam, possibly the most commonly employed benzodiazepine, has been used in the pharmacological treatment of anxiety since the early 60's. Its mechanism of action on the Central Nervous System is believed to be related to the ability to enhance the activity of gamma aminobutyric acid (GABA), the major inhibitory neurotransmitter (Kopp et al 2004, Puga et al 2005.…”

mentioning

confidence: 99%

The influence of bromazepam on cortical power distribution

Sampaio

Puga

Veiga

et al. 2008

An. Acad. Bras. Ciênc.

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The EEG has been widely employed in the assessment of electrophysiological changes induced by distinct medications. Its sensibility in detecting alterations produced by a specific substance may be enhanced by methods of quantitative analyses (qEEG). The present study aimed at investigating the modulatory effects of bromazepam on brain dynamics. The effects of bromazepam (3mg) on EEG power distribution were tested in 10 healthy individuals, in a double-blind experiment. The electrophysiological measure was analyzed across experimental conditions, moments, and electrodes, in the delta, theta, alpha and beta frequency bands separately. A significant decrease of relative power was observed in delta and theta (main effect of condition). No interactions were observed. Although the expected anxiolytic EEG profile was not observed (increased beta and decreased alpha activity), this specific result may be related to other factors such as dosage used and the subjects' general physiological state, and not necessarily to the drug itself.

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“…2008;Versiani, 1997). It acts on the central neural system as an inhibitor of the neurotransmitter gamma aminobutyric acid (GABA) (Khan et al 2010;Kopp et al, 2004, Machado et al, 2005Puga et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Study of the Pepsin Enzymatic Activity in in-vitro Dissolution Test of Bromazepam Tablets by UV/VIS Spectrophotometry

Nascimento¹

2012

J. App. Pharm. Sci.

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The in vitro dissolution test is an essential parameter to determine the properties of biopharmaceutical formulations. Therefore, the purpose of this study was to evaluate the dissolution of solid Bromazepam formulations and different enzyme concentrations. The dissolution test for Bromazepam tablets was performed using a Vankel VK 7000, apparatus 2 (paddle), at temperature of 37.0°C. The dissolution medium simulated gastric fluid with pepsin, which was prepared with 2 g of sodium chloride, varying concentrations of purified pepsin and 7 mL of hydrochloric acid (PA) in 1000 mL of water. The pH was maintained close to 1.2. The results obtained in the dissolution test showed that the samples have been influenced by the presence of pepsin for both similar drug and reference drug. Among the various enzyme concentrations tested, the highest enzyme concentration tested showed the best results. Thus, it could be concluded that the increase in enzyme concentration increases the dissolution of both drugs, causing a decrease in the test time.

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Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300)

Cited by 11 publications

References 20 publications

Effects of modafinil and bromazepam on decision-making: a P300 analysis

Effects of modafinil and bromazepam on decision-making: a P300 analysis

The influence of bromazepam on cortical power distribution

Study of the Pepsin Enzymatic Activity in in-vitro Dissolution Test of Bromazepam Tablets by UV/VIS Spectrophotometry

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