In view of the problems of poor stability and low precision of rapier belt motion of spatial four-bar weft insertion mechanism, the mechanism was optimized from two aspects, i.e., motion parameters and structural stiffness. Firstly, the motion law of the rapier belt was analyzed based on the spatial mechanism theory, and its correctness was verified by software simulation, so as to provide a theoretical basis for the optimization design. Then, minimize the maximum acceleration of the rapier belt and the constraint condition of meeting the requirements of weft insertion technology and performance, the mechanism was optimized and analyzed using ADAMS parametric modeling. Considering the non-negligible flexibility of the weft insertion mechanism working at high speed, a rigid-flexible coupling model was established and simulated. Finally, with the connecting rod as an example, aiming at reducing the acceleration error of the rapier belt, a method was proposed to reduce the influence of the flexible deformation of the component by increasing the section size and improving the structural stiffness. The results showed that the maximum acceleration of the rapier belt after optimizing the motion parameters was reduced by 35.7%, and the motion stability was improved; After the structural stiffness was optimized, the acceleration error of the rapier belt was significantly reduced, and the motion accuracy was improved.