Analysis of the mechanism of skeletal deformity in fish larvae using a vitamin A-induced bone deformity model

Haga, Yutaka; Du, Shao Jun; Satoh, Shuichi; Kotani, Tomonari; Fushimi, Hiroshi; Takeuchi, Toshio

doi:10.1016/j.aquaculture.2010.11.026

Cited by 37 publications

(40 citation statements)

References 96 publications

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“…The most important are vitamin C [1,[42][43][44][45] , aminoacidic (tryptophan) [45] and phosphorous [46,47] deficiencies. On the contrary, excess of vitamin A is known to induce skeletal abnormalities in fish and such vitamin A-induced lesions also represent a popular model for studying the development of skeleton in fish larvae [48] .…”

Section: Discussionmentioning

confidence: 99%

“…Particularly, the so-called Mutant Guppy (P. reticulata) Syndrome Curveback, characterized by a primary sagittal lordosis with some individual exhibiting posterior kyphosis and /or coronal deviation, appears to be a possible animal model to study the pathogenesis of human idiopathic scoliosis. This Curveback lineage, originated from a curved male crossed to a normal female, followed by full-sib mating, showed a female bias for curves of high magnitude [48] . It is interesting to notice that both founders were from a population collected in Cumaná, Venezuela [57] which has been proposed to be an established local population of P. wingei [13] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Spinal deformities in a wild line of Poecilia wingei bred in captivity: report of cases and review of the literature

Arbuatti¹,

Salda

Romanucci

2013

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Spinal deformities in a wild line of Poecilia wingei bred in captivity: report of cases and review of the literature

Arbuatti¹,

Salda

Romanucci

2013

Asian Pacific Journal of Tropical Biomedicine

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“…Although previous studies have demonstrated that feeding with high levels of dietary nutrients (e.g., lipids, fatty acids, vitamins) can improve growth and survival and significantly reduce skeletal malformation (Koven et al 2003;Izquierdo et al 2013), excessive dietary lipids (e.g., DHA, DHA/EPA) and vitamins (e.g., vitamin A, C) can also lead to low survival (Fernández and Gisbert 2011;Hamre et al 2013;Ma and Qin 2014a) and high malformation (Izquierdo et al 2010;Haga et al 2011;Izquierdo et al 2013). Up to present, it is still unclear what the most suitable enrichment formula is for Artemia nauplii enrichment in rearing golden pompano larvae.…”

Section: Introductionmentioning

confidence: 98%

Molecular cloning and expression analysis of the retinoid X receptor (RXR) gene in golden pompano Trachinotus ovatus fed Artemia nauplii with different enrichments

Yang

Zheng

et al. 2015

Fish Physiol Biochem

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The retinoid X receptors (RXRs) are involved in the skeletal development and other biological process such as blood vessel formation and metabolism. Partial sequences of RXRα and β genes were obtained, and their expressions were quantified on golden pompano Trachinotus ovatus at 28 days post hatching (DPH) to explore the molecular response to nutritional manipulation in fish larvae. As live food, Artemia nauplii were separately enriched with Nannochloropsis and Algamac 3080 and non-enriched Artemia nauplii (control) for fish feeding. The expressions of RXRs were detected in the embryos and fish larvae at early stages, suggesting that the skeletal development in golden pompano initiated before yolk re-sorption completion. Fish fed non-enriched Artemia nauplii ended up with higher jaw malformation. The highest specific growth rate was obtained when fish were fed with the Artemia nauplii enriched with Algamac 3080, and the lowest growth rate was observed when fish were fed with unenriched Artemia nauplii. The highest survival was obtained when fish were fed with non-enriched or Nannochloropsis-enriched Artemia nauplii. This study indicates that the use of enriched formula for Artemia nauplii can significantly affect the expression levels of RXRs and jaw malformation of golden pompano larvae, but there is no clear correlation between RXRs expressions and malformation rates when fish are subjected to nutrient challenge.

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“…Retinoids (vitamin A) are part of the latter group and these compounds have been found to be modulated by environmental pollutants in fish (Zhang et al 2002;Barim and Karatepe 2010). Surface water contaminants such as pesticides (e.g., atrazine, metolachlor) have been reported to modify the retinoic signalling pathway (Bérubé et al 2005;Novák et al 2008) and to induce organism malformations (e.g., skeletal deformities) in fish larvae (Inoue et al 2010;Yutaka et al 2011). Metals have been found to alter retinoidmetabolizing enzymes (Defo et al 2014), changes in gene transcription (Pierron et al 2011) or dysfunction of hepatic storage capacity (Defo et al 2012) in fish.…”

Section: Introductionmentioning

confidence: 98%

Integrated spatial health assessment of yellow perch (Perca flavescens) populations from the St. Lawrence River (QC, Canada), part B: cellular and transcriptomic effects

Bruneau

Landry

Giraudo

et al. 2016

Environ Sci Pollut Res

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Multi-biological level assessments have become great tools to evaluate the health of aquatic ecosystems. Using this approach, a complementary study was designed to evaluate the health of yellow perch (Perca flavescens) populations in the St. Lawrence River (Quebec, Canada). In the present study, stress responses were compared at the transcriptomic, cellular, and tissue levels in yellow perch collected at six sites along the river: Lake St. François, Lake St. Louis (north and south), Beauregard Island and Lake St. Pierre (north and south). These results complement the physiological and chemical parameters as well as pathogen infection investigated in a companion paper published in the present issue. Thiobarbituric acid reactive substance (TBARS) analyses indicated the presence of oxidative stress in fish collected in the southern part of Lake St. Louis and at the downstream sites of Lake St. Pierre. High lipid peroxidation levels were found in the muscle of yellow perch caught at Beauregard Island, located downstream of the Montreal's wastewater treatment plant, suggesting an impact of the municipal effluent on redox homeostasis. Transcriptomic results indicated the down-regulation of genes related to lipid, glucose, and retinoid in southern Lake St. Pierre as well as a decrease in retinoid storage. Overall, biochemical and molecular markers indicated that the health status of yellow perch followed a decreasing gradient from upstream to downstream of the St. Lawrence River. This gradient is representative of the cumulative negative impacts of human activities on water and habitat quality along the river.

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Analysis of the mechanism of skeletal deformity in fish larvae using a vitamin A-induced bone deformity model

Cited by 37 publications

References 96 publications

Spinal deformities in a wild line of Poecilia wingei bred in captivity: report of cases and review of the literature

Spinal deformities in a wild line of Poecilia wingei bred in captivity: report of cases and review of the literature

Molecular cloning and expression analysis of the retinoid X receptor (RXR) gene in golden pompano Trachinotus ovatus fed Artemia nauplii with different enrichments

Integrated spatial health assessment of yellow perch (Perca flavescens) populations from the St. Lawrence River (QC, Canada), part B: cellular and transcriptomic effects

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