Analysis of the metabolites of ethyl loflazepate by gas chromatography with electron-capture detection

Cano, J. P.; Sumirtapura, Yeyet C.; Cautreels, W.; Sales, Y.

doi:10.1016/s0378-4347(00)86075-2

Cited by 10 publications

(3 citation statements)

References 6 publications

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“…This metabolite is then decarboxylated into DCL (Fig. Decarboxylation also occurs during sampling, storage, and extraction of biological fluids (Cautreek et al, 1980;Can0 et al, 1981). Decarboxylation also occurs during sampling, storage, and extraction of biological fluids (Cautreek et al, 1980;Can0 et al, 1981).…”

Section: Analytical Methodology and Expression Of Resultsmentioning

confidence: 99%

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EFFECT OF RENAL FAILURE ON THE PHARMACOKINETICS OF ETHYL LOFLAZEPATE (Victan®) IN MAN

Iliadis

Durand

et al. 1989

Fundamemntal Clinical Pharma

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The kinetics of ethyl loflazepate were studied in patients with various degrees of renal failure. A strong correlation was noted between urinary excretion of metabolite loflazepate and creatinine clearance. In contrast, elimination half-life and total plasma clearance of the sum of loflazepate + descarboxyloflazepate seemed to be independent of the degree of renal impairment. These results indicate the absence of a risk of accumulation of the 2 main and active metabolites of ethyl loflazepate in patients with renal failure.

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Section: Analytical Methodology and Expression Of Resultsmentioning

confidence: 99%

“…1). Decarboxylation also occurs during sampling, storage, and extraction of biological fluids (Cautreek et al, 1980;Can0 et al, 1981). Because of the chemical instability of L, which is partially and nonreproducibly transformed into DCL, only the sum of L + DCL can be determined accurately.…”

Section: Analytical Methodology and Expression Of Resultsmentioning

confidence: 99%

EFFECT OF RENAL FAILURE ON THE PHARMACOKINETICS OF ETHYL LOFLAZEPATE (Victan®) IN MAN

Iliadis

Durand

et al. 1989

Fundamemntal Clinical Pharma

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“…Since the parent drug is extensively biotransformed, plasma levels of the carboxylic acid metabolite (Ml) and the decarboxylated metabolite (M2) were measured by high performance liquid chromatograph based on the gas chromatography/electron capture method described by Cano et al (1981). Standard accurate levels of each metabolite cannot be obtained separately, so total Ml + M2 levels are used.…”

Section: Methodsmentioning

confidence: 99%

The respiratory effects of oral ethyl loflazepate in volunteers.

Fazackerley

Randall

Pleuvry

et al. 1987

Brit J Clinical Pharma

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1 A volunteer study was undertaken to assess the respiratory effects of ethyl loflazepate, a new benzodiazepine, and to correlate these with plasma concentrations of the active metabolites. 2 Twelve volunteers were given placebo, 2 mg ethyl loflazepate, and 6 mg ethyl loflazepate on separate occasions. Respiration and plasma metabolite levels were assessed hourly for 8 h and at 24 h. 3 The 6 mg ethyl loflazepate treatment produced a significant decrease (P < 0.02) in the ventilatory response to carbon dioxide at 5 h. However this did not equate with a peak in plasma metabolite concentrations which were maintained at a plateau level from 4 to 24 h.

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Determination of Ethyl Loflazepate, an Anxiolytic Benzodiazepine, in Human Plasma by High-Performance Liquid Chromatography

Kintz

Tracqui

Boukhabza³

et al. 1988

Archives of Toxicology

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Analysis of the metabolites of ethyl loflazepate by gas chromatography with electron-capture detection

Cited by 10 publications

References 6 publications

EFFECT OF RENAL FAILURE ON THE PHARMACOKINETICS OF ETHYL LOFLAZEPATE (Victan®) IN MAN

EFFECT OF RENAL FAILURE ON THE PHARMACOKINETICS OF ETHYL LOFLAZEPATE (Victan®) IN MAN

The respiratory effects of oral ethyl loflazepate in volunteers.

Determination of Ethyl Loflazepate, an Anxiolytic Benzodiazepine, in Human Plasma by High-Performance Liquid Chromatography

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