Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome‐associated keratocystic odontogenic tumor

Abstract

The results implied that heparanase expression may be correlated with the neoplastic properties of KCOT, particularly in NBCCS-associated cases.

Targeting the Sonic Hedgehog Pathway in Keratocystic Odontogenic Tumor

“…These major EMPs have been shown to have preferential expression in dental tissues, in particular the developing enamel producing ameloblasts (24). Prior studies have determined the localization of apoptosis and proliferation markers and an invasion-associated enzyme heparanase (25,26). Although these markers were broadly expressed, relative expression levels were useful in the potential classification of NBCCS from sporadic KCOTs and nonspecified odontogenic cysts.…”

Nevoid basal cell carcinoma syndrome

“…Favoring the neoplastic nature of OK, various studies showed the expression of bcl-2, p53, p63, and Ki-67 14,15 . OKs have show loss of heterozygosity for PTCH, which is also indicative of its neoplastic nature, explaining the close relationship with the NBCCS 3 .…”

“…Recently reclassified as keratocystic odontogenic tumor, the OK is a benign, aggressive cystic lesion of the jaws 14 . Favoring the neoplastic nature of OK, various studies showed the expression of bcl-2, p53, p63, and Ki-67 14,15 .…”

Gorlin - goltz syndrome: a case report

“…It is locally destructive, despite its bland histological features. 13,14 Agram et al 15 examined (10) odontogenic keratocysts for loss of heterozygosity of tumor suppressor genes. The loss of heterozygosity was seen in 7 of 10 cases, the mutation of genomic DNA in these cysts supports the hypothesis that they are neoplastic rather than developmental in origin.…”