Analysis of the Pathogenetic Mechanisms of Chronic Joint Pain in Patients With Rheumatoid Arthritis and Knee Osteoarthritis

Филатова, Е. С.; Туровская, Екатерина Федоровна; Алексеева, Л. И.; Эрдес, Ш. Ф.; Филатова, Е. Г.

doi:10.14412/1995-4484-2014-631-635

Cited by 10 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…При описании своих жалоб пациенты с РА нередко используют такие термины, как «жжение», «покалывание», или указывают на усиление боли при прикосновении к суставу [6,7], что характерно для невропатической или дисфункциональной боли.…”

unclassified

Neuropathic pain in rheumatoid arthritis

Филатова¹,

Лила

Parfenov

2020

RJTAO

Self Cite

View full text Add to dashboard Cite

Objective: to identify the signs of neuropathic pain (NP) in patients with rheumatoid arthritis (RA) on the basis of the PainDETECT questionnaire and neurological examination.Patients and methods. A total of 208 RA patients (39 men and 169 women; mean age, 47.7 years) with chronic pain syndrome were examined. The patients underwent rheumatological and neurological examinations; NP was diagnosed using the PainDETECT questionnaire; inflammation severity (DAS28 index), pain intensity (VAS), affective disorders (HADS), and quality of life (EQ-5D) were assessed.Results and discussion. 172 (82.7%) patients had moderate and high disease activity according to the DAS28. The signs of possible and highly probable NP according to the PainDETECT questionnaire were detected in 29.8 and 26.9% of patients, respectively; they were significantly more likely to be detected in patients with more severe pain syndrome, clinically significant anxiety, and worse quality of life, but were unassociated with RA activity according to the DAS28. Somatosensory nervous system injury (polyneuropathy, tunnel syndromes, and cervical myelopathy) was found in 77.6% of patients with possible NP and in 80.4% with highly probable NP. In other patients, NP might be caused by central sensitization. Conclusion. In patients with a RA exacerbation, chronic pain syndrome is caused not only by an active inflammatory process in the joint area and adjacent tissues, but also by somatosensory nervous system injury and central sensitization.

show abstract

unclassified

Neuropathic pain in rheumatoid arthritis

Филатова¹,

Лила

Parfenov

2020

RJTAO

Self Cite

View full text Add to dashboard Cite

show abstract

“…Последнему аспекту придается особое значение как принципиально важному фактору хронизации боли. По данным российских и зарубежных авторов, элементы центральной сенситизации -гипералгезия и аллодиния, выявленные с помощью опросников DN4, PainDETECT и углубленного неврологического обследования, определяются примерно у 30% пациентов с ОА и НБС [11].…”

Section: значение проблемыunclassified

Personalization of the use of non-steroidal anti-inflammatory drugs for musculoskeletal diseases. Resolution on the results of the Meeting of Experts of December 13, 2017

et al. 2018

View full text Add to dashboard Cite

The personalization of therapy is one of the innovative approaches gaining an increasingly strong foothold in modern medicine, implying an individual approach to each patient, taking into account the individual characteristics of the patient and the specific clinical case. This same standpoint of personified therapy should be used to plan rational analgesic therapy, the most important component of managing patients with the most common and socially significant diseases, with conditions that have a significant impact on the patient’s quality of life and worsen the course of concomitant diseases. The Meeting of Experts of different specialties such as rheumatologists, neurologists, cardiologists and clinical pharmacologists considered the key aspects of the prescription of NSAIDs, the most widely used class of painkillers, including those used for the relief of musculoskeletal pain. It was noted that when choosing NSAIDs, the practitioner should take into account the diagnosis, the planned duration of analgesic therapy, the intensity of pain, medical history data, the presence of comorbid diseases and risk factors for drug complications. There are different types of NSAIDs, some of which are most useful for urgent acute pain therapy (eg, ketoprofen), while others are most suitable for long-term pain management in chronic diseases (eg, etoricoxib). In any case, the practitioner should take into account the priority of patient safety and pay the utmost attention to the prevention of NSAIDassociated complications, and also keep in mind the duration of the specific drug administration permitted by the patient information leaflet. It was also noted that the launch of a new generic etoricoxib (Kostarox®) expands the possibilities of analgesic therapy for the Russian practitioners.

show abstract

“…Парфеновым, что для точной диагностики анатомического субстрата боли необходимо проведение диагностической блокады. Рассматривались различные фенотипы скелетно-мышечной боли при боли в спине: воспалительный (боль ночью и в покое, скованность, уменьшение после начала движения, при разминке), боль, связанная с механическим стрессом (появление боли при нагрузке, в вертикальном положении, при конкретных движениях, уменьшение или полное прекращение боли в состоянии покоя), обусловленная поражением связок (сочетание «воспалительной» и «механической» боли), связанная с центральной сенситизацией (несоответствие между выраженной клинической картиной и умеренными структурными изменениями, яркая эмоциональная окраска боли, распространенная боль, «невропатические дескрипторы») [9][10][11]. А.Е.…”

unclassified

Post-release of the symposium «How to Deal with Pain in the 21st Century? Expert Opinions» (November 8, 2021, XII Interdisciplinary International Congress «Manage Pain»)

Остроумова¹

2021

RJTAO

View full text Add to dashboard Cite

The article presents the chronology of the symposium «How to Deal with Pain in the 21st Century? Experts' opinions», which took place on November 8 during the XII interdisciplinary international congress «Manage Pain». The lectures discussed issues of non-steroidal anti-inflammatory drugs (NSAIDs), including etoricoxib (Atorika tabs), administration on the example of a clinical case, problems of terminology associated with the concepts of «lumbago» and «sciatica», rare clinical syndromes (for example, heavy-purse syndrome) that we need to differentiate nonspecific back pain with, strategies for choosing NSAIDs in patients with osteoarthritis, the importance of timely administration of NSAIDs in the prevention of chronic pain syndromes, the influence of emotional and cognitive factors on the back pain chronization. The benefits of etoricoxib (Atorika) in the treatment of chronic back pain were reviewed, as well as the evidence for its safety.

show abstract

Analysis of the Pathogenetic Mechanisms of Chronic Joint Pain in Patients With Rheumatoid Arthritis and Knee Osteoarthritis

Cited by 10 publications

References 0 publications

Neuropathic pain in rheumatoid arthritis

Neuropathic pain in rheumatoid arthritis

Personalization of the use of non-steroidal anti-inflammatory drugs for musculoskeletal diseases. Resolution on the results of the Meeting of Experts of December 13, 2017

Post-release of the symposium «How to Deal with Pain in the 21st Century? Expert Opinions» (November 8, 2021, XII Interdisciplinary International Congress «Manage Pain»)

Contact Info

Product

Resources

About