The construction industry’s rapid growth significantly impacts energy consumption and environmental health. It is crucial to develop optimization strategies to enhance green building energy efficiency and encompass comprehensive analysis methods. This study aims to introduce and validate a novel framework for optimizing energy efficiency design in green buildings by integrating Building Information Modeling (BIM) technology, Life Cycle Cost (LCC) analysis, and orthogonal testing methods, focusing on enhancing energy efficiency and reducing life cycle costs. The optimization parameters for the building envelope are identified by analyzing energy consumption components and key green building factors. The orthogonal testing method was applied to streamline design options. Building Energy Consumption Simulation (BECS) software and LCC analysis tools were employed to calculate each optimized option’s total annual energy consumption and the current life cycle costs. Using the efficiency coefficient method, each optimization scheme’s energy consumption and economic indicators were thoroughly analyzed. The framework’s validity and applicability were confirmed through an empirical analysis of a campus green building case in Fujian Province, demonstrating that the optimized framework could reduce energy consumption by 4.85 kWh/m2 per year and lower costs by 38.89 Yuan/m2 compared to the reference building. The case study highlights the framework’s significant benefits in enhancing environmental performance and economic gains. The results provide critical parameter selection and offer scientific and technological support for the design of building energy efficiency, promoting optimization techniques and sustainable development within the construction industry.