Analysis of the Power of Common Diagnostic Tools in the Management of Acute Pancreatitis

Nistal, Markus; Zoltani, Malalai; Lohse, Ansgar W.; Daniele, Nicola Di; Tesauro, Manfredi; Pace, Andrea

doi:10.1155/2014/438697

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…Compared with other laboratory parameters studied, CRP showed overwhelming advantages in predicting MSAP/SAP, necrosis, and infected necrosis. These results parallel conclusions from previous studies and indicate that CRP is the best biomarker to assess the evolution of AP 18,27,30,31 . In addition, creatinine showed a high predictive value to assess OF and death.…”

Section: Discussionsupporting

confidence: 89%

“…These results parallel conclusions from previous studies and indicate that CRP is the best biomarker to assess the evolution of AP. 18,27,30,31 In addition, creatinine showed a high predictive value to assess OF and death.…”

Section: Discussionmentioning

confidence: 95%

“…It has a sensitivity of 80%, a specificity of 84%, and an area under the curve (AUC) of 0.84 to predict AP severity 48 hours after the onset of symptoms with a cut-off point of 150 mg/L. 30 This is the reason why many pancreatologists consider CRP the reference determination as a predictor of AP severity 48 hours after admission, 18,31 although a faster (within the first 24 hours) predictive marker would be highly appreciated.…”

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confidence: 99%

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Predictive Value of Antithrombin III and d-Dimer in the Development of Moderate-To-Severe Acute Pancreatitis

Garcia Borobia,

Flores Clotet,

Bejarano Gonzalez

et al. 2023

Pancreas

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Objectives To analyze if antithrombin III (AT-III) and d-dimer levels at admission and at 24 hours can predict acute pancreatitis (AP) progression to moderately severe AP (MSAP) to severe AP (SAP) and to determine their predictive value on the development of necrosis, infected necrosis, organ failure, and mortality. Methods Prospective observational study conducted in patients with mild AP in 2 tertiary hospitals (2015–2017). Results Three hundred forty-six patients with mild AP were included. Forty-four patients (12.7%) evolved to MSAP/SAP. Necrosis was detected in 36 patients (10.4%); in 10 (2.9%), infection was confirmed. Organ failure was recorded in 9 patients (2.6%), all of whom died. Those who progressed to MSAP/SAP showed lower AT-III levels; d-dimer and C-reactive protein (CRP) levels increased. The best individual marker for MSAP/SAP at 24 hours is CRP (area under the curve [AUC], 0.839). Antithrombin III (AUC, 0.641), d-dimer (AUC, 0.783), and creatinine added no benefit compared with CRP alone. Similar results were observed for patients who progressed to necrosis, infected necrosis, and organ failure/death. Conclusion Low AT-III and high d-dimer plasma levels at 24 hours after admission were significantly associated with MSAP/SAP, although their predictive ability was low. C-reactive protein was the best marker tested. Clinical Study Identifier ClinicalTrials.gov NCT02373293

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

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Predictive Value of Antithrombin III and d-Dimer in the Development of Moderate-To-Severe Acute Pancreatitis

Garcia Borobia,

Flores Clotet,

Bejarano Gonzalez

et al. 2023

Pancreas

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“…In the article titled “Analysis of the Power of Common Diagnostic Tools in the Management of Acute Pancreatitis” [ 1 ], the name of one of the authors was given incorrectly as Malai. The author's name should have been written as Malalai.…”

mentioning

confidence: 99%

Corrigendum to “Analysis of the Power of Common Diagnostic Tools in the Management of Acute Pancreatitis”

Nistal

Zoltani

Lohse

et al. 2018

Gastroenterology Research and Practice

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Radiomics and 256-slice-dual-energy CT in the automated diagnosis of mild acute pancreatitis: the innovation of formal methods and high-resolution CT

Rocca,

Brunese,

Santone

et al. 2024

Radiol med

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Introduction Acute pancreatitis (AP) is a common disease, and several scores aim to assess its prognosis. Our study aims to automatically recognize mild AP from computed tomography (CT) images in patients with acute abdominal pain but uncertain diagnosis from clinical and serological data through Radiomic model based on formal methods (FMs). Methods We retrospectively reviewed the CT scans acquired with Dual Source 256-slice CT scanner (Somatom Definition Flash; Siemens Healthineers, Erlangen, Germany) of 80 patients admitted to the radiology unit of Antonio Cardarelli hospital (Naples) with acute abdominal pain. Patients were divided into 2 groups: 40 underwent showed a healthy pancreatic gland, and 40 affected by four different grades (CTSI 0, 1, 2, 3) of mild pancreatitis at CT without clear clinical presentation or biochemical findings. Segmentation was manually performed. Radiologists identified 6 patients with a high expression of diseases (CTSI 3) to formulate a formal property (Rule) to detect AP in the testing set automatically. Once the rule was formulated, and Model Checker classified 70 patients into “healthy” or “unhealthy”. Results The model achieved: accuracy 81%, precision 78% and recall 81%. Combining FMs results with radiologists agreement, and applying the mode in clinical practice, the global accuracy would have been 100%. Conclusions Our model was reliable to automatically detect mild AP at primary diagnosis even in uncertain presentation and it will be tested prospectively in clinical practice.

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Analysis of the Power of Common Diagnostic Tools in the Management of Acute Pancreatitis

Cited by 4 publications

References 12 publications

Predictive Value of Antithrombin III and d-Dimer in the Development of Moderate-To-Severe Acute Pancreatitis

Predictive Value of Antithrombin III and d-Dimer in the Development of Moderate-To-Severe Acute Pancreatitis

Corrigendum to “Analysis of the Power of Common Diagnostic Tools in the Management of Acute Pancreatitis”

Radiomics and 256-slice-dual-energy CT in the automated diagnosis of mild acute pancreatitis: the innovation of formal methods and high-resolution CT

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