Analysis of the QRS morphology in lead V1 during 24-hour Holter electrocardiogram monitoring to evaluate function of a cardiac resynchronisation therapy device in patients with sinus rhythm: a pilot study

Pyszno-Prokopowicz, Dominika; Madej, Magdalena; Baranowski, Rafał; Piotrowicz, Ryszard

doi:10.5603/kp.a2014.0246

Cited by 6 publications

(1 citation statement)

References 10 publications

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“…Artificial pacemaker implantation can be the most effective treatment for SSS; however, the procedure is cost intensive with a high probability of postoperative atrial fibrillation. Moreover, conservative SSS treatment, mostly focused on the administration of atropine, isoprenaline, and other similar drugs, has serious side effects that can result in life-threatening malignant arrhythmias [2][3][4]. Scientifically validated traditional Chinese medicine modalities applicable to SSS treatment are needed urgently.…”

Section: Introductionmentioning

confidence: 99%

NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules

Zhang

Chen

Liu

et al. 2022

Oxidative Medicine and Cellular Longevity

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Population aging has led to increased sick sinus syndrome (SSS) incidence; however, no effective and safe medical therapy has been reported thus far. Yixin-Fumai granules (YXFMs), a Chinese medicine granule designed for bradyarrhythmia treatment, can effectively increase SSS patients’ heart rate. Senescence-induced sinoatrial node (SAN) degeneration is an important part of SSS pathogenesis, and older people often show high levels of oxidative stress; reactive oxygen species (ROS) accumulation in the SAN causes abnormal SAN pacing or conduction functions. The current study observed the protective effects of YXFMs on senescent SAN and explored the relationship between the NRF-2/HO-1 pathway, SHOX2, and T-type calcium channels. We selected naturally senescent C57BL/6 mice with bradycardia to simulate SSS; electrocardiography, Masson’s trichrome staining, and DHE staining were used to assess SAN function and tissue damage. Immunofluorescence staining and Western blotting were used to assay related proteins. In vitro, we treated human-induced pluripotent stem cell-derived atrial myocytes (hiPSC-AMs) and mouse atrial myocyte-derived cell line HL-1 with D-galactose to simulate senescent SAN-pacemaker cells. CardioExcyte96 was used to evaluate the pulsatile function of the hiPSC-AMs, and the mechanism was verified by DCFH-DA, immunofluorescence staining, RT-qPCR, and Western blotting. The results demonstrated that YXFMs effectively inhibited senescence-induced SAN hypofunction, and this effect possibly originated from scavenging of ROS and promotion of NRF-2, SHOX2, and T-type calcium channel expression. In vitro experiment results indicated that ML385, si-SHOX2, LDN193189, and Mibefradil reversed YXFMs’ effects. Moreover, we, for the first time, found that ROS accumulation may hinder SHOX2 expression; YXFMs can activate SHOX2 through the NRF-2/HO-1 pathway-mediated ROS scavenging and then regulate CACNA1G through the SHOX2/BMP4/GATA4/NKX2-5 axis, improve T-type calcium channel function, and ameliorate the SAN dysfunction. Finally, through network pharmacology and molecular docking, we screened for the most stable YXFMs compound that docks to NRF-2, laying the foundation for future studies.

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Section: Introductionmentioning

confidence: 99%

NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules

Zhang

Chen

Liu

et al. 2022

Oxidative Medicine and Cellular Longevity

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Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome

Zhang

Hao

et al. 2021

Journal of Ethnopharmacology

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R/S Ratio Variability in Lead V₁Observed between Selected Four 1‐Minute ECG Fragments of 24‐Hour ECG as a Predictor of Incomplete Resynchronization during Full 24‐Hour ECG: Pilot Study

Pyszno-Prokopowicz

Baranowski

Bodalski

et al. 2015

Noninvasive Electrocardiol

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Analysis of the QRS morphology in lead V1 during 24-hour Holter electrocardiogram monitoring to evaluate function of a cardiac resynchronisation therapy device in patients with sinus rhythm: a pilot study

Abstract: In patients with preserved SR, device interrogation and evaluation of 24-h ECG are complementary methods to evaluate adequate CRT delivery. Therefore, both methods should be taken into account when assessing CRT function.

Cited by 6 publications

References 10 publications

NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules

NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules

Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome

R/S Ratio Variability in Lead V₁Observed between Selected Four 1‐Minute ECG Fragments of 24‐Hour ECG as a Predictor of Incomplete Resynchronization during Full 24‐Hour ECG: Pilot Study

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Analysis of the QRS morphology in lead V1 during 24-hour Holter electrocardiogram monitoring to evaluate function of a cardiac resynchronisation therapy device in patients with sinus rhythm: a pilot study

Abstract: In patients with preserved SR, device interrogation and evaluation of 24-h ECG are complementary methods to evaluate adequate CRT delivery. Therefore, both methods should be taken into account when assessing CRT function.

Cited by 6 publications

References 10 publications

NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules

NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules

Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome

R/S Ratio Variability in Lead V1Observed between Selected Four 1‐Minute ECG Fragments of 24‐Hour ECG as a Predictor of Incomplete Resynchronization during Full 24‐Hour ECG: Pilot Study

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R/S Ratio Variability in Lead V₁Observed between Selected Four 1‐Minute ECG Fragments of 24‐Hour ECG as a Predictor of Incomplete Resynchronization during Full 24‐Hour ECG: Pilot Study