Analysis of the Relationship between Asthma and Coffee/Green Tea/Soda Intake

Abstract

This study aimed to evaluate the association between asthma and the intake of coffee/green tea/soda. We used Health Examinee data from the Korean Genome and Epidemiology Study (2004–2016). The participants (n = 3146 with asthma; n = 158,902 non-asthma) were asked about the frequency and amount of their coffee/green tea/soda intake. Multiple logistic regression analyses were used to calculate the adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for asthma according to the frequency and amount of coffee/green tea/soda intake. Compared to the group consuming no coffee, the aORs for asthma were 0.82 (95% CI = 0.73–0.93, p = 0.002) in the group consuming coffee 1–2 times/day and 0.87 (95% CI = 0.78–0.97, p = 0.011) in the group consuming coffee in quantities of 1 cup, respectively. However, the frequency and amount of green tea and soda consumption were not significantly associated with asthma after adjusting for coffee consumption (all p > 0.05). These findings were consistent in the female subgroup (1–2 times/day: aOR = 0.76, 95% CI = 0.66–0.87, p < 0.001, and 1 cup each time: aOR = 0.79, 95% CI = 0.70–0.90, p < 0.001) but not in the male subgroup. Drinking 1 cup of coffee each time and 1–2 times per day may have protective effects against asthma in a Korean population. However, the associations between asthma and green tea/soda cannot be clearly established.

Association of Coffee and Tea Consumption with the Risk of Asthma: A Prospective Cohort Study from the UK Biobank

“…Specifically, only regularly light-to-moderate coffee drinkers (0.5 to 3 cups per day) could significantly reduce the risk of adult-onset asthma incidence. The protective effects disappeared in heavy drinkers of coffee and tea in the study, which was inconsistent with the study of Wee et al [ 12 ]. However, the beneficial J-shaped effect of coffee and tea intakes has been extensively reported in other diseases with large prospective cohort studies, such as stroke, dementia [ 7 ], and cancer mortality [ 27 ].…”

“…Herein, the effect of caffeine consumption from coffee and tea was significant in the females but not in the males. The sex discrepancy was also reported in a previous study showing that coffee consumption was inversely associated with asthma in women but not in men [ 12 ], which might be explained by the faster caffeine clearance in males than females due to the inhibited CYP1A2 activity by estradiol. In addition, smoking was also reported to be associated with faster caffeine metabolism and heavy coffee drinking because of the higher CYP1A2 activity in smokers [ 34 ].…”

“…Most studies investigating the relationship between coffee and tea consumption with asthma incidence were stuck 20 years ago with inconsistent results [ 11 , 13 , 14 ]. Although a new study of 173,209 participants and 3146 cases from Korea reported a relationship between coffee and tea intake and the prevalence of asthma, the cross-sectional design was not sufficient to infer causality [ 12 ]. To date, large longitudinal cohort studies were lacking to determine the relationship between coffee and tea intake and asthma.…”

“…Several studies investigated the relationship between coffee and tea consumption and the prevalence and incidence of asthma; however, the conclusions were not consistent. Cross-sectional studies suggested that coffee consumption may link to a low prevalence of asthma [ 11 , 12 ]. Chronic coffee consumption appeared to be associated with improved asthma control [ 13 ].…”

“…Chronic coffee consumption appeared to be associated with improved asthma control [ 13 ]. Moreover, another study found an association between tea consumption and prevalence/incidence of asthma in the crude model; however, this association became statistically insignificant in the adjusted model [ 12 ]. In addition, a recent cross-sectional/prospective cohort study also found no significant association between coffee or tea consumption and asthma prevalence [ 14 ].…”