Analysis of the relationship between hospital characteristics and survival in ovarian cancer: A historical cohort

Moterani, Vinicius Cesar; Tiezzi, Daniel Guimarães; Andrade, Jurandyr Moreira de; Reis, Francisco José Candido dos

doi:10.1002/jso.26186

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…For this reason, patients who develop HSRs should be seen and tested within one to two weeks of the reaction. This underscores the importance of a multidisciplinary approach to gynecologic cancer care in specialized centers and adherence to clinical guidelines, which ensures a better prognosis and quality of life for patients [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. In particular, it has been shown that the collaboration of different experts leads to an increased awareness of potential treatments and a better evaluation of diagnostic–therapeutic areas beyond their own competence, which ultimately improves the effectiveness of treatments [ 28 , 29 , 30 , 31 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Management of Patients with Hypersensitivity to Platinum Salts and Taxane in Gynecological Cancers: A Cross-Sectional Study by the European Network of Young Gynaecologic Oncologists (ENYGO)

Zwimpfer,

Bilir,

Gasimli

et al. 2024

Cancers

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Platinum and taxane chemotherapy is associated with the risk of hypersensitivity reactions (HSRs), which may require switching to less effective treatments. Desensitization to platinum and taxane HSRs can be used to complete chemotherapy according to the standard regimen. Therefore, we aimed to investigate the current management of HSRs to platinum and/or taxane chemotherapy in patients with gynecologic cancers. We conducted an online cross-sectional survey among gynecological and medical oncologists consisting of 33 questions. A total of 144 respondents completed the survey, and 133 respondents were included in the final analysis. Most participants were gynecologic oncologists (43.6%) and medical oncologists (33.8%), and 77.4% (n = 103) were involved in chemotherapy treatment. More than 73% of participants experienced >5 HSRs to platinum and taxane per year. Premedication and a new attempt with platinum or taxane chemotherapy were used in 84.8% and 92.5% of Grade 1–2 HSRs to platinum and taxane, respectively. In contrast, desensitization was used in 49.4% and 41.8% of Grade 3–4 HSRs to platinum and taxane, respectively. Most participants strongly emphasized the need to standardize the management of platinum and taxane HSRs in gynecologic cancer. Our study showed that HSRs in gynecologic cancer are common, but management is variable and the use of desensitization is low. In addition, the need for guidance on the management of platinum- and taxane-induced HSRs in gynecologic cancer was highlighted.

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Section: Discussionmentioning

confidence: 99%

Management of Patients with Hypersensitivity to Platinum Salts and Taxane in Gynecological Cancers: A Cross-Sectional Study by the European Network of Young Gynaecologic Oncologists (ENYGO)

Zwimpfer,

Bilir,

Gasimli

et al. 2024

Cancers

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“…Evidence indicates that ovarian cancer patients benefit from surgical treatment being performed in high-volume hospitals 19 . In São Paulo, ovarian cancer has demonstrated high rates of centralization 20 . Disruptions to healthcare services challenge this centralized model since patient treatment could be impacted if resources in a region become suddenly unavailable.…”

Section: Discussionmentioning

confidence: 99%

Impact of ICU bed availability on ovarian cancer surgical hospitalization rates during the first wave of the coronavirus disease 2019 pandemic

Moterani

Pimentel

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVES:The coronavirus disease 2019 pandemic, which began in 2020, disrupted healthcare services. Reports of changes in surgical activities coincide with the outbreak period. We aimed to identify if changes could be determined in hospitalization rates of ovarian cancer patients from 2016 to 2020, comparing pre-pandemic and pandemic levels. METHODS: Aggregated data were obtained from the State of São Paulo Secretary of Health regarding ovarian cancer clinical and surgical hospitalization, both Coronavirus disease-specific ICU and infirmary bed occupation rates, average social distancing rates, coronavirus disease 2019 incidence, mortality, and lethality rates. We performed the joinpoint analysis to verify if there were changes regarding hospitalization rates during this period. We also calculated hospitalization rate ratios and tested if they were correlated with pandemic-related variables. RESULTS: Hospitalization rates in the state fell, coinciding with the pandemic. Surgical hospitalization rate ratios were inversely correlated with Coronavirus disease-specific ICU bed occupation rates during the third trimester of 2020, with a Pearson's correlation coefficient of -0.50 (95%CI -0.78 to -0.05, p=0.03). CONCLUSION: These results demonstrate the impact of the coronavirus disease 2019 pandemic on the treatment of conditions that compete for the same healthcare resources.

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“…Evidence indicates that ovarian cancer patients bene t from surgical treatment being performed in high-volume hospitals [23]. In Sao Paulo, ovarian cancer has demonstrated high rates of centralization, with a majority of patients included in the Hospital Cancer Registry being treated in high-volume hospitals [24]. Disruptions to healthcare services such as the COVID-19 pandemic challenge this centralized model.…”

Section: Discussionmentioning

confidence: 99%

Impact of ICU bed availability on ovarian cancer surgical hospitalization rates during the first wave of the COVID-19 pandemic: an ecological study.

Moterani

Pimentel

et al. 2022

Preprint

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PurposeThe COVID-19 pandemic, which began in 2020, disrupted healthcare services. Reports of changes in surgical activity coincide with the outbreak period. We aimed to identify if any changes could be determined in hospitalization rates of ovarian cancer patients from 2016 to 2020, comparing pre-pandemic and pandemic levels. ResultsHospitalization rates in the state fell, coinciding with the pandemic. Surgical hospitalization rate ratios were inversely correlated with COVID-specific ICU bed occupation rates during the third trimester of 2020, with a Pearson Correlation coefficient of -0.50 (95% CI: -0.78 to -0.05, p = 0.03). Observed ovarian cancer hospitaliation rates were 85% compared to expected values if pre-pandemic trends were mantained.ConclusionA 15% reduction on ovarian cancer hospitalization rates was identified in this scenario. ICU availability was inversely correlated with ovarian cancer surgical activity. These results demonstrate the impact of the COVID-19 pandemic on the treatment of conditions that compete for the same healthcare resources.

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Analysis of the relationship between hospital characteristics and survival in ovarian cancer: A historical cohort

Cited by 7 publications

References 21 publications

Management of Patients with Hypersensitivity to Platinum Salts and Taxane in Gynecological Cancers: A Cross-Sectional Study by the European Network of Young Gynaecologic Oncologists (ENYGO)

Management of Patients with Hypersensitivity to Platinum Salts and Taxane in Gynecological Cancers: A Cross-Sectional Study by the European Network of Young Gynaecologic Oncologists (ENYGO)

Impact of ICU bed availability on ovarian cancer surgical hospitalization rates during the first wave of the coronavirus disease 2019 pandemic

Impact of ICU bed availability on ovarian cancer surgical hospitalization rates during the first wave of the COVID-19 pandemic: an ecological study.

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