Analysis of the Relationship BetweenADIPOR1Variants and the Susceptibility of Chronic Metabolic Diseases in a Northeast Han Chinese Population

Abstract

Objective: Shared genetic variants in ADIPOR1 have been identified as closely related to coronary artery disease (CAD), type 2 diabetes (T2D), and T2D with CAD susceptibility, suggesting that these variants are strong candidates for the common soil hypothesis. Therefore, it is essential to analyze the relationship between ADIPOR1 variants and the susceptibility to CAD, T2D, and T2D with CAD in other populations.Materials and Methods: A case–control study was conducted which included three case cohorts [CAD (n = 316), T2D (n = 295), T2D with CAD (n = 302)], and a control cohort (n = 268) from a population in northeast China. Six ADIPOR1 single-nucleotide polymorphisms were genotyped by high-resolution melting and polymerase chain reaction–restriction fragment length polymorphism.Results: We confirmed that the shared variant, rs3737884*G, in ADIPOR1 is associated with CAD, T2D, and T2D with CAD (p-value range: 6.54E-6–1.82E-5, odds ratio [OR] range: 1.770–1.844) and that rs16850797*C is associated with T2D and T2D with CAD (p-value range: 0.001–0.001, OR range: 1.529–1.571). We also found that a novel shared variant, rs7514221*C, is associated with an increased susceptibility to CAD, T2D, and T2D with CAD (p-value range: 0.002–0.004, OR range: 1.194–2.382) in this population.Conclusions: ADPOR1 variants, rs3737884*G and rs7514221*C, may be shared risk factors associated with CAD, T2D, and T2D with CAD in a population of northeast China.

Coronary Heart Disease in Type 2 Diabetes Mellitus: Genetic Factors and Their Mechanisms, Gene-Gene, and Gene-Environment Interactions in the Asian Populations

“…In this regard, common ADIPOR1 gene variants have been implicated with CHD in non-diabetic Asian subjects [ 63 , 67 ]. Likewise, the gene also has a significant association with CHD in T2D.…”

“…Among the Northeast Chinese population, three out of six ADIPOR1 variants were markedly associated with a higher CHD risk. They include rs3737884*G (OR: 2.69), rs16850797*C (OR: 1.44), and rs7514221*C (OR: 1.75) [ 67 ]. However, there was no assessment of the genotypic impact on clinical variables performed in the study [ 67 ].…”

“…They include rs3737884*G (OR: 2.69), rs16850797*C (OR: 1.44), and rs7514221*C (OR: 1.75) [ 67 ]. However, there was no assessment of the genotypic impact on clinical variables performed in the study [ 67 ]. In a separate study among a North Chinese population, T2D individuals with ADIPOR1 variants rs3737884*G (OR: 2.42) and rs16850797*C (OR: 1.71) had a significantly higher CHD risk as well [ 63 ].…”

“…Combinations of two risk alleles from either one of the two SNPs produced a similar effect with an OR of 2.44 ( p = 0.002), while the presence of three and more risk alleles further increased the risk to 3.38 times ( p = 1.14 × 10 −5 ) [ 63 ]. Meanwhile, in a study by Wang et al (2016), three individual polymorphisms markedly associated with increased CHD risk were reported at 1.84 times ( p = 6.54 × 10 −6 ) for rs3737884*A/G, 1.57 times ( p = 0.001) for rs16850797*G/C, as well as 1.70 times ( p = 0.002) for rs7514221*T/C in a T2D Chinese population [ 67 ]. A commonly occurring haplotype with a combination of GCT alleles from the respective polymorphisms did not result in a higher CHD risk than their individual effects (OR: 1.61, p = 8.74 × 10 −4 ) [ 67 ].…”

Variations in ADIPOR1 But Not ADIPOR2 are Associated With Hypertriglyceridemia and Diabetes in an Admixed Latin American Population

“…Similarly, Jin et al (2014) found an association between two SNPs in ADIPOR1 (rs3737884 and rs16850797) and T2DM in a Chinese population [53], and recently another study successfully replicated these findings with subjects from Northeastern China. Moreover, a third SNP (rs7514221) in ADIPOR1 was also found to be associated with an increased risk of T2DM [54].…”