Analysis of the Relationships between Multiple Endocrine Hormones and Return of Spontaneous Circulation (ROSC) in Cardiac Arrest Patients: Possible Association of the Serum Free T4 Level with ROSC

Koizumi, Go; Mikura, Kentaro; Iida, Takatoshi; Kaji, Mariko; Hashizume, Mai; Murai, Norimitsu; Kigawa, Yasuyoshi; Endo, Kei; Iizaka, Toru; Saiki, Ryo; Otsuka, Fumiko; Sasaki, Jun; Hayashi, Masanori; Nagasaka, Shoichiro

doi:10.1155/2020/4168420

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…As for the metabolic analysis of I/R, the GAT1 group had a lower level of acidosis and base intake than the CG group, suggesting that the combination of adrenaline and candesartan can protect myocardial tissue and improve energy metabolism after ROSC. Since candesartan is one of the most potent aldosterone suppressors and higher potassium levels are implicated in lower ROSC rates, we expected higher potassium levels on GAT1 48 – 50 . However, potassium levels were lower 10 min after ROSC.…”

Section: Discussionmentioning

confidence: 95%

Effect of AT1 receptor blockade on cardiovascular outcome after cardiac arrest: an experimental study in rats

Araújo Filho,

Carmona,

Otsuki

et al. 2023

Sci Rep

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Angiotensin II receptor 1(AT1) antagonists are beneficial in focal ischemia/reperfusion (I/R). However, in cases of global I/R, such as cardiac arrest (CA), AT1 blocker's potential benefits are still unknown. Wistar male rats were allocated into four groups: Control group (CG)—animals submitted to CA by ventricular fibrillation induced by direct electrical stimulation for 3 min, and anoxia for 5 min; Group AT1 (GAT1)—animals subjected to CA and treated with 0.2 mg/kg of candesartan diluted in dimethylsulfoxide (DMSO) (0.1%); Vehicle Group (VG): animals subjected to CA and treated with 0.2 ml/kg of DMSO and Sham group (SG)—animals submitted to surgical interventions, without CA. Cardiopulmonary resuscitation consisted of group medications, chest compressions, ventilation, epinephrine (20 mcg/kg) and defibrillation. The animals were observed up to 4 h after spontaneous circulation (ROSC) return, and survival rates, hemodynamic variables, histopathology, and markers of tissue injury were analyzed. GAT1 group had a higher rate of ROSC (62.5% vs. 42.1%, p < 0.0001), survival (100% vs. 62.5%, p = 0.027), lower incidence of arrhythmia after 10 min of ROSC (10% vs. 62.5%, p = 0.000), and lower neuronal and cardiac injury scores on histology evaluation (p = 0.025 and p = 0.0052, respectively) than GC group. The groups did not differ regarding CA duration, number of adrenaline doses, or number of defibrillations. AT1 receptor blockade with candesartan yielded higher rates of ROSC and survival, in addition to neuronal and myocardial protection.

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Section: Discussionmentioning

confidence: 95%

Effect of AT1 receptor blockade on cardiovascular outcome after cardiac arrest: an experimental study in rats

Araújo Filho,

Carmona,

Otsuki

et al. 2023

Sci Rep

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“…The search strategy identified a total of 11,834 records, of which 6914 were non‐duplicates. After applying all inclusion and exclusion criteria, 118 studies were included in the scoping review, as shown in Figure 1 11–128 …”

Section: Resultsmentioning

confidence: 99%

“…After applying all inclusion and exclusion criteria, 118 studies were included in the scoping review, as shown in Figure 1 . 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 ,…”

Section: Resultsmentioning

confidence: 99%

Intra‐arrest blood‐based biomarkers for out‐of‐hospital cardiac arrest: A scoping review

Benoit,

Hogan,

Connelly

et al. 2024

JACEP Open

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ObjectiveBlood‐based biomarkers play a central role in the diagnosis and treatment of critically ill patients, yet none are routinely measured during the intra‐arrest phase of out‐of‐hospital cardiac arrest (OHCA). Our objective was to describe methodological aspects, sources of evidence, and gaps in research surrounding intra‐arrest blood‐based biomarkers for OHCA.MethodsWe used scoping review methodology to summarize existing literature. The protocol was designed a priori following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) Extension for Scoping Reviews. Inclusion criteria were peer‐reviewed scientific studies on OHCA patients with at least one blood draw intra‐arrest. We excluded in‐hospital cardiac arrest and animal studies. There were no language, date, or study design exclusions. We conducted an electronic literature search using PubMed and Embase and hand‐searched secondary literature. Data charting/synthesis were performed in duplicate using standardized data extraction templates.ResultsThe search strategy identified 11,834 records, with 118 studies evaluating 105 blood‐based biomarkers included. Only eight studies (7%) had complete reporting. The median number of studies per biomarker was 2 (interquartile range 1–4). Most studies were conducted in Asia (63 studies, 53%). Only 22 studies (19%) had blood samples collected in the prehospital setting, and only six studies (5%) had samples collected by paramedics. Pediatric patients were included in only three studies (3%). Out of eight predefined biomarker categories of use, only two were routinely assessed: prognostic (97/105, 92%) and diagnostic (61/105, 58%).ConclusionsDespite a large body of literature on intra‐arrest blood‐based biomarkers for OHCA, gaps in methodology and knowledge are widespread.

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“…[9] World J Emerg Med, Vol 14, No 2, 2023 Factors that predict ROSC and long-term survival in patients with OHCA have been studied, including prehospital information, such as age, sex, witnesses, bystander cardiopulmonary resuscitation (CPR), cause leading to cardiac arrest, and initial rhythm. [10] According to blood tests, various factors, such as levels of K + , [11,12] Na + , [13] blood glucose, [13] ammonia, [14] brain natriuretic peptide, [15] lactate, [16][17][18] and free thyroxine 4, [19] have been reported to affect the prognosis of OHCA. Moreover, significant activation of coagulation occurs as a part of the pathogenesis after cardiac arrest.…”

Section: Introductionmentioning

confidence: 99%

Prediction of return of spontaneous circulation in out-of-hospital cardiac arrest with non-shockable initial rhythm using point-of-care testing: a retrospective observational study

Shinada¹

2023

World Journal of Emergency Medicine

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BACKGROUND: Out-of-hospital cardiac arrest (OHCA) is a public health concern, and many studies have been conducted on return of spontaneous circulation (ROSC) and its prognostic factors. Rotational thromboelastometry (ROTEM ® ), a point-of-care testing (POCT) method, has been useful for predicting ROSC in patients with OHCA, but very few studies have focused on patients with non-shockable rhythm. We examined whether the parameters of POCT could predict ROSC in patients with OHCA and accompanying non-shockable rhythm.METHODS: This is a single-center, retrospective observational study. Complete blood count, blood gas, and ROTEM POCT measurements were used. This study included patients with nontraumatic OHCA aged 18 years or older who were transported to the emergency department and evaluated using POCT between January 2013 and December 2021. The patients were divided into the ROSC and non-ROSC groups. Prehospital information and POCT parameters were compared using receiver operating characteristic (ROC) curve analysis, and further logistic regression analysis was performed.RESULTS: Sixty-seven and 135 patients were in the ROSC and non-ROSC groups, respectively. The ROC curves showed a high area under the curve (AUC) for K + of 0.77 (95% confidence interval [CI]: 0.71-0.83) and EXTEM amplitude 5 min after clotting time (A5) of 0.70 (95%CI: 0.62-0.77). The odds ratios for ROSC were as follows: female sex 3.67 (95%CI: 1.67-8.04); K + 0.64 (95%CI: 0.48-0.84); and EXTEM A5 1.03 (95%CI: 1.01-1.06). CONCLUSION:In OHCA patients with non-shockable rhythm, K + level and the ROTEM parameter EXTEM A5 may be useful in predicting ROSC.

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Analysis of the Relationships between Multiple Endocrine Hormones and Return of Spontaneous Circulation (ROSC) in Cardiac Arrest Patients: Possible Association of the Serum Free T4 Level with ROSC

Cited by 4 publications

References 25 publications

Effect of AT1 receptor blockade on cardiovascular outcome after cardiac arrest: an experimental study in rats

Effect of AT1 receptor blockade on cardiovascular outcome after cardiac arrest: an experimental study in rats

Intra‐arrest blood‐based biomarkers for out‐of‐hospital cardiac arrest: A scoping review

Prediction of return of spontaneous circulation in out-of-hospital cardiac arrest with non-shockable initial rhythm using point-of-care testing: a retrospective observational study

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