Analysis of the role op histamine in inhibitory avoidance in goldfish

Medalha, Carla Cristina; Coelho, J.L; Mattioli, Rosana

doi:10.1016/s0278-5846(99)00091-3

Cited by 22 publications

(17 citation statements)

References 33 publications

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“…Similar findings have been reported in several other studies (10,11,17,18). Thus, we believe that the results for the fish in the A-SAL and S-SAL groups were opposite in terms of memory consolidation of the inhibitory avoidance task due to the absence of cerebellar modulation in limbic structures in the ablation group, especially in the MP, which is thought to be homologous to the amygdala (29)(30)(31).…”

Section: Discussionsupporting

confidence: 89%

“…Similarly, both systemic and intracerebroventricular administration of α-fluormethylhistidine delayed the acquisition of active avoidance in mice (24). In other studies, Medalha et al (18) reported that chlorpheniramine facilitates inhibitory avoidance training in goldfish in a doserelated manner.…”

Section: Discussionmentioning

confidence: 85%

“…In this procedure, learning is inferred when the animal reduces its preference for dark places, which is an innate behavior of the species (16), associating the black compartment with an aversive experience. Several studies have used this model to investigate the action of different drugs on learning and memory processes and on processes of functional recovery in goldfish, indicating that the model is appropriate for this purpose (11,17,18).…”

Section: Discussionmentioning

confidence: 99%

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L-histidine reduces inhibitory avoidance in Carassius auratus submitted to cerebellar ablation

Garção

Mattioli

2009

Braz J Med Biol Res

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The effect of post-training treatment with L-histidine (LH) on the memory consolidation of inhibitory avoidance was investigated in Carassius auratus submitted to cerebellar ablation. The inhibitory avoidance procedure included 3 days: one habituation day, one training day (5 trials, T1-T5) and one test day. On the training day, each fish was placed individually in a white compartment separated from a black compartment by a sliding door. When the fish crossed into the black compartment, a weight was dropped in front of it (aversive stimulus) and the time to cross was recorded. Saline or LH (100 mg/kg) was injected intraperitoneally 10 min after the trials. Data were log 10 transformed and analyzed by ANOVA and the Student-Newman-Keuls test (P < 0.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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L-histidine reduces inhibitory avoidance in Carassius auratus submitted to cerebellar ablation

Garção

Mattioli

2009

Braz J Med Biol Res

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“…There are studies indicating that structures in the teleostean telencephalon are involved in spatial learning and memory in a manner similar to that of the hippocampus of land vertebrates (Salas et al, 1996;Lopez et al, 2000). It has also been proposed that the ascending histaminergic fibers in the forebrain have an inhibitory role on learning and memory in goldfish (Medalha et al, 2000). The hippocampus has also been implicated in the processes of attention and alertness.…”

Section: Functional Aspects Of the Monoaminergic System In Zebrafishmentioning

confidence: 99%

Comparative anatomy of the histaminergic and other aminergic systems in zebrafish (Danio rerio)

Kaslin

Panula

2001

J of Comparative Neurology

381

484

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The histaminergic system and its relationships to the other aminergic transmitter systems in the brain of the zebrafish were studied by using confocal microscopy and immunohistochemistry on brain whole-mounts and sections. All monoaminergic systems displayed extensive, widespread fiber systems that innervated all major brain areas, often in a complementary manner. The ventrocaudal hypothalamus contained all monoamine neurons except noradrenaline cells. Histamine (HA), tyrosine hydroxylase (TH), and serotonin (5-HT) -containing neurons were all found around the posterior recess (PR) of the caudal hypothalamus. TH- and 5-HT-containing neurons were found in the periventricular cell layer of PR, whereas the HA-containing neurons were in the surrounding cell layer as a distinct boundary. Histaminergic neurons, which send widespread ascending and descending fibers, were all confined to the ventrocaudal hypothalamus. Histaminergic neurons were medium in size (approximately 12 microm) with varicose ascending and descending ipsilateral and contralateral fiber projections. Histamine was stored in vesicles in two types of neurons and fibers. A close relationship between HA fibers and serotonergic raphe neurons and noradrenergic locus coeruleus neurons was evident. Putative synaptic contacts were occasionally detected between HA and TH or 5-HT neurons. These results indicate that reciprocal contacts between monoaminergic systems are abundant and complex. The results also provide evidence of homologies to mammalian systems and allow identification of several previously uncharacterized systems in zebrafish mutants.

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“…Much research has been done to investigate the influences of the central histaminergic system (CHS) on CNS functions. Among them are circadian rhythm (2), anxiety (3)(4)(5), pain perception (6), locomotor activity modulation (7), learning and memory processes (8)(9)(10)(11), synaptic plasticity, and CNS functional recovery (12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Chlorpheniramine impairs functional recovery in Carassius auratus after telencephalic ablation

Garção

Canto-de-Souza

Romaguera

et al. 2009

Braz J Med Biol Res

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We determined the effect of an H 1 receptor antagonist on the functional recovery of Carassius auratus submitted to telencephalic ablation. Five days after surgery the fish underwent a spatial-choice learning paradigm test. The fish, weighing 6-12 g, were divided into four groups: telencephalic ablation (A) or sham lesion (S) and saline (SAL) or chlorpheniramine (CPA, ip, 16 mg/kg). For eight consecutive days each animal was trained individually in sessions separated by 24 h (alternate days). Training trials (T1-T8) consisted of finding the food in one of the feeders, which were randomly blocked for each subject. Animals received an intraperitoneal injection of SAL or CPA 10 min after the training trials. The time spent by the animals in each group to find the food (latency) was analyzed separately at T1 and T8 by the Kruskal-Wallis test, followed by the Student Newman-Keuls test. At T1 the latencies (mean ± SEM) of the A-SAL (586.3 ± 13.6) and A-CPA (600 ± 0) groups were significantly longer than those of the S-SAL (226.14 ± 61.15) and S-CPA (356.33 ± 68.8) groups. At T8, the latencies of the A-CPA group (510.11 ± 62.2) remained higher than those of the other groups, all of which showed significantly shorter latencies (A-SAL = 301.91 ± 78.32; S-CPA = 191.58 ± 73.03; S-SAL = 90.28 ± 41) compared with T1. These results support evidence that training can lead to functional recovery of spatial-choice learning in telencephalonless fish and also that the antagonist of the H 1 receptor impairs it.

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Analysis of the role op histamine in inhibitory avoidance in goldfish

Cited by 22 publications

References 33 publications

L-histidine reduces inhibitory avoidance in Carassius auratus submitted to cerebellar ablation

L-histidine reduces inhibitory avoidance in Carassius auratus submitted to cerebellar ablation

Comparative anatomy of the histaminergic and other aminergic systems in zebrafish (Danio rerio)

Chlorpheniramine impairs functional recovery in Carassius auratus after telencephalic ablation

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