Memristors are widely used in hardware security applications. Research progress in memristor‐based physical unclonable functions (PUFs), random number generators (RNGs), and chaotic circuits is reviewed. To enhance device security, PUFs and RNGs apply randomness of memristors and incorporate 3D crossbars to amplify the number of challenge‐response pairs and provide proof of the destruction of the key, which enables the administrator to firmly control the device information. In addition, the image encryption technique based on the chaotic system is summarized. Furthermore, an assessment of the research advancement in PUFs, RNGs, and chaotic circuits is conducted. This Review examines the characteristics, applications, progress, and challenges of memristors in hardware security and compares the benefits and limitations of different schemes as accelerators for hardware information protection.