Analysis of the second generation antidepressant venlafaxine and its main active metabolite O-desmethylvenlafaxine in human plasma by HPLC with spectrofluorimetric detection

Mandrioli, Roberto; Mercolini, Laura; Cesta, Roberta; Fanali, Salvatore; Amore, Mario; Raggi, Maria Augusta

doi:10.1016/j.jchromb.2007.05.046

Cited by 45 publications

(35 citation statements)

References 23 publications

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“…The plasma was pipetted into glass tubes and then frozen at −20°C until analysis by high-performance liquid chromatography (HPLC). The quantitative determination of VenHCl in human plasma was performed by a reverse-phase HPLC procedure described by Mandrioli et al (16). The mobile phase was composed of a mixture of acetonitrile (25%, v/v) and a pH6.8, 40 mM phosphate buffer containing 0.…”

Section: In Vivo Absorption Studiesmentioning

confidence: 99%

Optimization and In vivo Pharmacokinetic Study of a Novel Controlled Release Venlafaxine Hydrochloride Three-Layer Tablet

Aboelwafa

Basalious

2010

AAPS PharmSciTech

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Abstract. Several matrix tablet formulations (hydrophilic-based, wax-based, and three-layer tablets) were designed for controlling the release of the highly water soluble drug, venlafaxine hydrochloride (VenHCl) for once-daily administration. The three-layer tablets consist of non-swellable, compritol-based middle layers containing the drug to which hydrophilic top and bottom barrier layers were applied. A 2 3 full-factorial design was employed for optimization and to explore the effect of different variables on the release rate of the drug from the three-layer tablets. The optimized levels of each independent variable were based on the criterion of desirability. The calculated values of f 1 and f 2 were 4.131 and 79.356, respectively; indicating that the release profile of the optimized PEO layered tablet formulation is comparable to that of the target release model. The pharmacokinetic parameters of VenHCl from the optimized three-layer tablet was compared to the marketed extended release capsule as a reference in healthy human subjects using a randomized crossover design. In this study, the 90% confidence interval for AUC 0-24 and AUC 0−∞ are within (0.8-1.25), which satisfied the bioequivalence criteria. It could be concluded that a promising once-daily extended-release three-layer tablet of the highly water soluble drug, VenHCl, was successfully designed.

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Section: In Vivo Absorption Studiesmentioning

confidence: 99%

Optimization and In vivo Pharmacokinetic Study of a Novel Controlled Release Venlafaxine Hydrochloride Three-Layer Tablet

Aboelwafa

Basalious

2010

AAPS PharmSciTech

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“…In the past, various high-performance liquid chromatography (HPLC) methods with UV detection (Zhang et al, 2007;Shen et al, 2002;Dusci et al, 2002), coulometric (Schatz and Saria, 2000) and fluorescence detection (Suckow et al, 1992;Kristoffersen et al, 1999;Mandrioli et al, 2007) have been reported to detect and quantify antipsychotic medications. Recently, several studies have utilized methods based on liquid chromatography coupled with mass spectrometry (LC-MS/MS) to increase sensitivity in detection with shorter run times (Urinovska et al, 2012, Ansermot et al, 2013.…”

Section: Introductionmentioning

confidence: 99%

Concurrent determination of olanzapine, risperidone and 9‐hydroxyrisperidone in human plasma by ultra performance liquid chromatography with diode array detection method: application to pharmacokinetic study

Kumar¹,

Ramanathan²

2015

Biomedical Chromatography

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A simple and sensitive ultra-performance liquid chromatography (UPLC) method has been developed and validated for simultaneous estimation of olanzapine (OLZ), risperidone (RIS) and 9-hydroxyrisperidone (9-OHRIS) in human plasma in vitro. The sample preparation was performed by simple liquid-liquid extraction technique. The analytes were chromatographed on a Waters Acquity H class UPLC system using isocratic mobile phase conditions at a flow rate of 0.3 mL/min and Acquity UPLC BEH shield RP18 column maintained at 40°C. Quantification was performed on a photodiode array detector set at 277 nm and clozapine was used as internal standard (IS). OLZ, RIS, 9-OHRIS and IS retention times were found to be 0.9, 1.4, .1.8 and 3.1 min, respectively, and the total run time was 4 min. The method was validated for selectivity, specificity, recovery, linearity, accuracy, precision and sample stability. The calibration curve was linear over the concentration range 1-100 ng/mL for OLZ, RIS and 9-OHRIS. Intra- and inter-day precisions for OLZ, RIS and 9-OHRIS were found to be good with the coefficient of variation <6.96%, and the accuracy ranging from 97.55 to 105.41%, in human plasma. The validated UPLC method was successfully applied to the pharmacokinetic study of RIS and 9-OHRIS in human plasma.

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“…Synthetic sorbents modified with specific reactive species or functional groups are commonly used for the selective adsorption of substances in accordance with their physical and chemical properties [4][5][6]. Porous HLB polymers, cyanopropyl (CN), phenylic (PH), and C1, C2, C8 types of SPE columns, as well as silicone covered with carboxymethyl cellulose as a filling material for SPE columns are commonly used for basic compounds extraction like amines from solutions and biological matrices [7][8][9][10]. However, in aggressive environment, particularly in strong acidic media, their sorption ability decreases significantly owing to the modifier reactant washing out.…”

Section: Introductionmentioning

confidence: 99%

High Performance Liquid Chromatographic Determination of Bupropion Using H-Clinoptilolite as a Sorbent for Plasma and Urine Purification

Halkevych¹,

Ivanauskas²,

Bidnychenko³

et al. 2015

ChChT

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Abstract. The coupling of solid-phase extraction (SPE) using H-clinoptilolite as an adsorbent with a high performance liquid chromatography (HPLC) method was developed for the high efficiency enrichment and rapid determination of bupropion in plasma and urine. The effect of the adsorbent particles size and pH on adsorption behavior of bupropion to H-clinoptilolite was evaluated. The experimental conditions of the sorbent preparation were developed, the effective solvents for the sorbent conditioning were chosen. The optimal eluent for bupropion extraction by H-clinoptilolite was chosen.

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Analysis of the second generation antidepressant venlafaxine and its main active metabolite O-desmethylvenlafaxine in human plasma by HPLC with spectrofluorimetric detection

Cited by 45 publications

References 23 publications

Optimization and In vivo Pharmacokinetic Study of a Novel Controlled Release Venlafaxine Hydrochloride Three-Layer Tablet

Optimization and In vivo Pharmacokinetic Study of a Novel Controlled Release Venlafaxine Hydrochloride Three-Layer Tablet

Concurrent determination of olanzapine, risperidone and 9‐hydroxyrisperidone in human plasma by ultra performance liquid chromatography with diode array detection method: application to pharmacokinetic study

High Performance Liquid Chromatographic Determination of Bupropion Using H-Clinoptilolite as a Sorbent for Plasma and Urine Purification

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