2021
DOI: 10.3390/ijms22147704
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Analysis of the Structural Mechanism of ATP Inhibition at the AAA1 Subunit of Cytoplasmic Dynein-1 Using a Chemical “Toolkit”

Abstract: Dynein is a ~1.2 MDa cytoskeletal motor protein that carries organelles via retrograde transport in eukaryotic cells. The motor protein belongs to the ATPase family of proteins associated with diverse cellular activities and plays a critical role in transporting cargoes to the minus end of the microtubules. The motor domain of dynein possesses a hexameric head, where ATP hydrolysis occurs. The presented work analyzes the structure–activity relationship (SAR) of dynapyrazole A and B, as well as ciliobrevin A an… Show more

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“…Dynein-1, instead, acts in post-cytosol transport of SV40. 30 Treating infected cells with a cytoplasmic dynein inhibitor, ciliobrevin D, 66 shows no indication of dynein involvement with the ER-to-cytosol penetration sites due to the lack of inhibitory effects at that stage. A reduced fraction of the disassembled SV40 by ciliobrevin D demonstrates that disruption of dynein-1 motility hinders SV40 disassembly.…”
Section: Polyomaviridae Familymentioning
confidence: 99%
“…Dynein-1, instead, acts in post-cytosol transport of SV40. 30 Treating infected cells with a cytoplasmic dynein inhibitor, ciliobrevin D, 66 shows no indication of dynein involvement with the ER-to-cytosol penetration sites due to the lack of inhibitory effects at that stage. A reduced fraction of the disassembled SV40 by ciliobrevin D demonstrates that disruption of dynein-1 motility hinders SV40 disassembly.…”
Section: Polyomaviridae Familymentioning
confidence: 99%