Analysis of the structure and strength of bones in celiac disease patients

Ferretti, J.L.; Mazure, Roberto M.; Tanoue, Patricio; Marino, A; Cointry, Gustavo Roberto; Vázquez, Horacio; Niveloni, Sonia I.; Pedreira, Silvia C.; Mauriño, Eduardo; Zanchetta, José R.; Bai, Julio C.

doi:10.1111/j.1572-0241.2003.07237.x

Cited by 16 publications

(5 citation statements)

References 36 publications

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“…The association between celiac disease and osteoporosis has been highlighted in a number of studies [13,26,53], and routine screening for osteoporosis among patients with celiac disease is recommended [13,54]. In this survey, of the total respondents, 35% had been diagnosed with osteoporosis or osteopenia and 57% reported having their bone density measured.…”

Section: Discussionmentioning

confidence: 94%

The Canadian Celiac Health Survey

et al. 2007

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The purpose of this study was to characterize the diagnostic process, frequency of associated disorders, family history, and impact of a gluten-free diet in individuals with celiac disease. All members of the Canadian Celiac Association (n=5240) were surveyed with a questionnaire. Respondents included 2681 adults with biopsy-proven celiac disease. The mean age was 56 years. Most common presenting symptoms included abdominal pain (83%), diarrhea (76%), and weight loss (69%). The mean delay in diagnosis was 11.7 years. Diagnoses made prior to celiac disease included anemia (40%), stress (31%), and irritable bowel syndrome (29%). Osteoporosis was common. Prior to diagnosis, 27% of respondents consulted three or more doctors about their symptoms. Delays in diagnosis of celiac disease remain a problem. Associated medical conditions occur frequently. More accurate food labeling is needed. Improved awareness of celiac disease and greater use of serological screening tests may result in earlier diagnosis and reduced risk of associated conditions.

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Section: Discussionmentioning

confidence: 94%

The Canadian Celiac Health Survey

et al. 2007

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“…These findings in cortical bone, despite seeming small, can be very important biologically, due to their mechanical correlate, in terms of bone strength. Previously, we had studied other parameters in CD patients employing standard peripheral quantitative computerized tomography-pQCT [25]. This technique can assess mechanical variables as the moment of inertia of the cortical bone cross sectional area (CSMI)-an indicator of the architectural efficiency of the bone designand bone strength index (BSI)-an estimation of the mechanical quality (stiffness and strength) of the whole bone-, calculated as the product of the vBMD of the cortical bone and the CSMI.…”

Section: Discussionmentioning

confidence: 99%

“…Some years ago, our group conducted a longitudinal analysis of bone structure and strength in a series of newly diagnosed CD patients using peripheral and axial quantitative computerized tomography (QCT) [25]. That seminal study allowed us to speculate about the pathogenesis of bone weakening in CD patients.…”

Section: Introductionmentioning

confidence: 99%

Significant bone microarchitecture impairment in premenopausal women with active celiac disease

Zanchetta

Costa²,

Longobardi

et al. 2015

Bone

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“…The pathogenesis of bone loss involves malabsorption of macronutrients, decreased bioavailability of calcium [111] and vitamin D [112], malnutrition and reduced muscle mass in some patients [113], and inflammatory cytokines [114][115][116]. Newly diagnosed adults often exhibit secondary hyperparathyroidism with increased bone turnover [113,115,[117][118][119][120], while children have reduced markers of bone formation but increased resorption indices [121][122][123][124]. Strict adherence to a gluten-free diet (GFD) reverses these abnormalities and results in rapid gains in bone mass, especially in children [125].…”

Section: Celiac Diseasementioning

confidence: 99%

Chronic pediatric inflammatory diseases: Effects on bone

Viswanathan

Sylvester

2007

Rev Endocr Metab Disord

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In children, chronic inflammatory diseases present a significant challenge to long-term skeletal health. These conditions are often associated with poor appetite and suboptimal overall nutrition, altered nutrient utilization, delayed puberty, inactivity, and reduced muscle mass, all of which can alter bone metabolism. In addition, bone cell activity is susceptible to the effects of the immune response that characterizes these diseases. Moreover, drugs used to treat these maladies, notably glucocorticoids, may have negative effects on bone formation and on linear growth in developing children. As a result, predicted peak bone mass may not be achieved, and fracture risk may be increased in the short term or in the future. Studies using primarily dual energy X-ray absorptiometry have documented that deficits in bone mass are common in these diseases. However, there are wide variations in the prevalence of low bone mass, largely due to differences in the characteristics of each study population. Recent studies provide insight into the pathogenesis of decreased bone mass in these conditions. In this paper we will provide an overview of the effects of chronic inflammatory conditions on bone mass in children. We will also present relevant data from adult patients, when pediatric data are scant or not available.

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Analysis of the structure and strength of bones in celiac disease patients

Cited by 16 publications

References 36 publications

The Canadian Celiac Health Survey

The Canadian Celiac Health Survey

Significant bone microarchitecture impairment in premenopausal women with active celiac disease

Chronic pediatric inflammatory diseases: Effects on bone

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