In 2014, the National Natural Science Foundation of China (NSFC) approved the Jinping Underground Nuclear Astrophysics laboratory (JUNA) project, which aims at direct cross-section measurements of four key stellar nuclear reactions right down to the Gamow windows. In order to solve the observed fluorine overabundances in Asymptotic Giant Branch (AGB) stars, measuring the key 19 F(p,α) 16 O reaction at effective burning energies (i.e., at Gamow window) is established as one of the scientific research sub-projects. The present paper describes this sub-project in details, including motivation, status, experimental setup, yield and background estimation, aboveground test, as well as other relevant reactions.Jinping Underground Nuclear Astrophysics laboratory (JUNA), direct measurement, Gamow window, cross section, AGB star, nucleosynthesis PACS number(s): 26.20.+f; 26.30.+k; 25.40.Ny, 27.20+n Citation:He J J, et al. A proposed direct measurement of cross section at Gamow window for key reaction 19 F(p,α) 16 O in Asymptotic Giant Branch stars with a planned accelerator in CJPL, Sci China-Phys Mech Astron, 2015, 58: 1-7, doi: