Analysis of the Therapeutic Effect of Nano-Silver on Periodontitis and Its Influence on Disease Recurrence

Abstract

Periodontitis is a chronic oral inflammatory disease that is difficult to treat and is therefore the subject of clinical research seeking new and effective treatment. Nano-silver has antibacterial and anti-inflammatory effects; however, its application in periodontitis is not well studied. In this study, we show decreases in periodontitis-associated inflammatory cytokines interleukin IL-4, IL-6, IL-8, IL-10, and tumor necrosis factor alpha (TNF-a) (P < 0.05) and in oxidative stress (P < 0.05) under intervention with nano-silver solution. The protein expression of CCL21, heat-shock protein 90 (HSP90), andE-selectin in periodontal tissues decreased (P < 0.05), while bone structure improved (P < 0.05). This work suggests that nano-silver solution can effectively inhibit the inflammatory response and oxidative stress response of periodontitis and improve the periodontal tissue and tooth structure to some extent; it may provide a new periodontitis treatment in the future.