Chang'e-5 (CE-5) mission was successful to return samples up to 1.8 kg from the northeastern part of the Rümker region, Moon. These samples can provide new understandings for the basaltic volcanism of northern Oceanus Prcellarum. Therefore, the terrain-related analysis of the Rümker region will become a hotspot in the recent and latter studies. As a typical surface analyzing method, multi-scale surface roughness has been used in planetary studies for a long time. However, fewer studies of topographic roughness analysis are applied in the Rümker region. The visual interpretations directly from digital elevation models (DEMs) or images potentially cause controversial results. To provide a way for re-understanding the geomorphological features in Rümker region, we investigate a new roughness analyzing method to extract the topographic signatures by using a wavelet-based V-system of degree 1. Based on these signatures, the hectometer-and kilometer-scale roughness are calculated and mapped. The multi-scale roughness textural changes are applied to provide new understandings of the geomorphological features of Rümker region. Our results demonstrate that: (1) most of younger mare units show lower roughness textures following with the scale increases. Especially at kilometer scales, a new understanding is given to units Im1 and Em1 based on the statistical variations of the geologic units; (2) Compared with the results obtained from the optical data, roughness maps provide a new way to recognize the wrinkle ridges in the Rümker region. The wrinkle ridges are re-evaluated based on the hectometer-and kilometer-scale roughness textural changes.