Analysis of the translationally controlled tumour protein in the nematodes Ostertagia ostertagi and Caenorhabditis elegans suggests a pivotal role in egg production

Meyvis, Yves; Houthoofd, Wouter; Visser, Aline; Borgonie, Gaëtan; Gevaert, Kris; Vercruysse, Jozef; Claerebout, Edwin; Geldhof, Peter

doi:10.1016/j.ijpara.2009.02.017

Cited by 16 publications

(16 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, we also observed variable uncoordinated phenotypes in several young C. elegans larvae that were able to bypass embryonic lethality, further suggesting an important role for RACK-1 and TCT-1 proteins in locomotion (Figure 5E). These results mirror those obtained in similar knockout studies (Meyvis et al 2009). Together, our results support a model where rack-1 and tct-1 use APA to counteract miRNAs in the body muscle tissue and allow their expression to support locomotion (Figure 5F).…”

Section: Resultssupporting

confidence: 90%

See 1 more Smart Citation

Alternative Polyadenylation Directs Tissue-Specific miRNA Targeting in Caenorhabditis elegans Somatic Tissues

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Resultssupporting

confidence: 90%

“…This gene is localized in the endoplasmic reticulum and known to be involved in growth, locomotion, and embryo and larval development (WormBase) (Meyvis et al 2009). We mapped a shorter 3′UTR isoform for tct-1 in the body muscle and a longer 3′UTR isoform expressed exclusively in the intestine (Figure S6B in File S1).…”

Section: Resultsmentioning

confidence: 99%

Alternative Polyadenylation Directs Tissue-Specific miRNA Targeting in Caenorhabditis elegans Somatic Tissues

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Specifically, the developmental expression of TCTP in the rat and human testes were studied by the group of Sanchez and Hochstrasser in Geneva (Guillaume et al 2001), and the importance of TCTP as a Ca 2+ -binding protein in the prostate (Arcuri et al 2004) and the placenta (Arcuri et al 2005) were demonstrated by Arcuri et al A more recent study showed that TCTP is essential for the implantation of embryos in the uterus of mice ). An important role for TCTP in egg production in nematodes, such as C. elegans, was demonstrated by TCTP knock-down, which severely reduced the number of eggs produced by these worms (Meyvis et al 2009), consistent with the role of TCTP for meiotic maturation demonstrated in mouse oocytes (Jeon et al 2016). 2.…”

Section: Roles For Tctp In Early Developmentsupporting

confidence: 68%

“…A study on TCTP in two nematode species, Ostertagia ostertagi, a parasitic nematode in cattle, and in the free-living nematode Caenorhabditis elegans revealed that in both species, TCTP was predominantly located in the eggs of the animals (Meyvis et al 2009). Interestingly, knock-down of TCTP in C. elegans reduced the number of eggs laid by the hermaphrodite in the F0 generation by 90%, indicating that TCTP plays a pivotal role in nematode reproduction.…”

Section: Tctp In Parasitic Wormsmentioning

confidence: 99%

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

View full text Add to dashboard Cite

The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes. It was first discovered about 35 years ago, and it took an extended period of time for its multiple functions to be revealed, and even today we do not yet fully understand all the details. Having witnessed most of this history, in this chapter, I give a brief overview and review the current knowledge on the structure, biological functions, disease involvements and cellular regulation of this protein. TCTP is able to interact with a large number of other proteins and is therefore involved in many core cell biological processes, predominantly in the response to cellular stresses, such as oxidative stress, heat shock, genotoxic stress, imbalance of ion metabolism as well as other conditions. Mechanistically, TCTP acts as an anti-apoptotic protein, and it is involved in DNA-damage repair and in cellular autophagy. Thus, broadly speaking, TCTP can be considered a cytoprotective protein. In addition, TCTP facilitates cell division through stabilising the mitotic spindle and cell growth through modulating growth signalling pathways and through its interaction with the proteosynthetic machinery of the cell. Due to its activities, both as an anti-apoptotic protein and in promoting cell growth and division, TCTP is also essential in the early development of both animals and plants. Apart from its involvement in various biological processes at the cellular level, TCTP can also act as an extracellular protein and as such has been involved in modulating whole-body defence processes, namely in the mammalian immune system. Extracellular TCTP, typically in its dimerised form, is able to induce the release of cytokines and other signalling molecules from various types of immune cells. There are also several examples, where TCTP was shown to be involved in antiviral/antibacterial defence in lower animals. In plants, the protein appears to have a protective effect against phytotoxic stresses, such as flooding, draught, too high or low temperature, salt stress or exposure to heavy metals. The finding for the latter stress condition is corroborated by earlier reports that TCTP levels are considerably up-regulated upon exposure of earthworms to high levels of heavy metals. Given the involvement of TCTP in many biological processes aimed at maintaining cellular or whole-body homeostasis, it is not surprising that dysregulation of TCTP levels may promote a range of disease processes, foremost cancer. Indeed a large body of evidence now supports a role of TCTP in at least the most predominant types of human cancers. Typically, this can be ascribed to both the anti-apoptotic activity of the protein and to its function in promoting cell growth and division. However, TCTP also appears to be involved in the later stages of cancer progression, such ...

show abstract

“…Guillaume et al [34] found high expression levels of TCTP in most stages of spermatogenesis, and Vitale et al [35] showed that TCTP expression is altered during murine oocyte maturation. Meyvis and coworkers [36] reported that knock-down of TCTP in C. elegans reduced the numbers of eggs laid by the hermaphrodite in the F(0) and F(1) generations, indicating a pivotal role of TCTP in egg production.…”

Section: • Tctp As a General Mitotic Regulatormentioning

confidence: 99%

Cellular Function and Regulation of the Translationally Controlled Tumour Protein TCTP

Bommer¹

2012

TOALLJ

View full text Add to dashboard Cite

Abstract:The 'translationally controlled tumour protein' TCTP was originally discovered 30 years ago by researchers interested in proteins regulated at the translational level. Cloning and sequencing confirmed the conservation of this protein among all eukaryotic kingdoms, but did not reveal any functional clue, and TCTP was listed in the databases as a 'family' of its own. The functional characterisation of this protein extended over more than a decade, leading to a plethora of individual functions and interactions that have been ascribed to this protein. A major addition to the functional characterisation of TCTP was the identification in 1995 of its histamine releasing factor (HRF) activity in allergic conditions, which for the first time described an extracellular activity for TCTP in human disease. This triggered a host of additional publications aimed at characterising this HRF activity, which are discussed in other articles of this issue. Another milestone in the elucidation of TCTP's function was the demonstration of its anti-apoptotic activity in 2001. Evidence is also accumulating for a role of TCTP in the cell cycle and in early development. This article provides an overview of the main cellular activities of TCTP. The second part will summarise our current knowledge on the mechanisms involved in regulating intracellular TCTP levels.

show abstract

Analysis of the translationally controlled tumour protein in the nematodes Ostertagia ostertagi and Caenorhabditis elegans suggests a pivotal role in egg production

Cited by 16 publications

References 31 publications

Alternative Polyadenylation Directs Tissue-Specific miRNA Targeting in Caenorhabditis elegans Somatic Tissues

Alternative Polyadenylation Directs Tissue-Specific miRNA Targeting in Caenorhabditis elegans Somatic Tissues

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Cellular Function and Regulation of the Translationally Controlled Tumour Protein TCTP

Contact Info

Product

Resources

About