Analysis of the vitamin D system in cutaneous squamous cell carcinomas

Reichrath, Jörg; Rafi, Leyla; Rech, Martin; Mitschele, Tanja; Meineke, Viktor; Гартнер, Барбара; Tilgen, Wolfgang; Holick, Michael F.

doi:10.1111/j.0303-6987.2003.00183.x

Cited by 57 publications

(64 citation statements)

References 41 publications

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“…Some of these studies have shown that VDR may be overexpressed or down-regulated in various human cancers (Friedrich et al, 2006;Kure et al, 2009;Lopes et al, 2012;Motomura et al, 1991;Matusiak et al, 2005;Reichrath et al, 2004). For instance, Matusiak et al (2005) demonstrated that the expression levels of VDR were low in normal epithelial cells of the colon while they were increased in aberrant crypts foci, in polyps, and in welldifferentiated cancer cells.…”

Section: Effects Of Cancer On Vdr Levelsmentioning

confidence: 99%

Vitamin D in cancer chemoprevention

Giammanco¹,

Majo²,

Guardia

et al. 2015

Pharmaceutical Biology

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Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo. Objective: The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy. Methods: A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar. Results and conclusion: Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents.

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Section: Effects Of Cancer On Vdr Levelsmentioning

confidence: 99%

Vitamin D in cancer chemoprevention

Giammanco¹,

Majo²,

Guardia

et al. 2015

Pharmaceutical Biology

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“…However, since VDRs were first discovered their localization has been confirmed on a variety of tissues. With respects to SCC, it has been demonstrated that not only do human cancer cell lines (SCL-1, SCL-2 ) exhibit VDR expression, but in fact they express the receptor in higher amounts than normal human skin cell lines 23 . The discovery of extra-renally expressed 1- hydroxylase and extra-skeletally expressed VDR was paramount in vitamin D's acceptance as a possible anticancer agent.…”

Section: Biological Plausibility Within Cancermentioning

confidence: 99%

Vitamin D3 and Its Role in the Treatment of Head and Neck Squamous Cell Carcinoma

Young¹,

Walker²

2012

Squamous Cell Carcinoma

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“…This observation further suggests a role for CYP27b1 in regulating proliferation and differentiation of these tissues. Examples include both basal cell [42] and squamous cell [43] carcinoma, breast cancer [35], colon cancer [32,33,44], prostate cancer (in which malignancy appears to reduce CYP27b1 expression and activity) [30,31], cervical cancer [36], and endometrial cancer [45]. Macrophages comprise a second large group of cells in which CYP27b1 expression and activity are well established.…”

Section: Tissue Distribution Of Cyp27b1mentioning

confidence: 99%

Extra Renal Synthesis of 1,25-dihydroxyvitamin D and its Health Implications

Bikle

2009

Clinic Rev Bone Miner Metab

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Although the kidney was initially thought to be the sole organ responsible for the production of 1,25(OH) 2 D 3 via its enzyme CYP27b1, it is now appreciated that the expression of CYP27b1 in tissues other than the kidney is wide spread. However, the kidney is the major source for circulating 1,25(OH) 2 D 3 . Therefore the existence of the capacity for extra renal 1,25(OH) 2 D 3 production begs the question why, and in particular whether the extra renal production of 1,25(OH) 2 D 3 has physiologic importance. In this chapter this question will be discussed. First a compilation of the extra renal sites for CYP27b1 expression is provided. This is followed by a discussion of the regulation of CYP27b1 expression and activity in extra renal tissues, pointing out that such regulation is tissue specific and different from that of CYP27b1 in the kidney. Finally the physiologic significance of extra renal 1,25(OH) 2 D 3 production is examined, with special focus on the role of CYP27b1 in regulation of cellular proliferation and differentiation, hormone secretion, and immune function. At this point the data do not clearly demonstrate an essential role for CYP27b1 expression in any tissue outside the kidney, but several examples pointing in this direction are provided. With the availability of the mouse enabling tissue-specific deletion of CYP27b1, the role of extra renal CYP27b1 expression can now be addressed definitively.

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Analysis of the vitamin D system in cutaneous squamous cell carcinomas

Cited by 57 publications

References 41 publications

Vitamin D in cancer chemoprevention

Vitamin D in cancer chemoprevention

Vitamin D3 and Its Role in the Treatment of Head and Neck Squamous Cell Carcinoma

Extra Renal Synthesis of 1,25-dihydroxyvitamin D and its Health Implications

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