Analysis of the VP2 protein gene of canine parvovirus strains from affected dogs in Japan

Soma, Takehisa; Taharaguchi, Satoshi; Ohinata, Tsuyoshi; Ishii, Hiroshi; Hara, Motonobu

doi:10.1016/j.rvsc.2012.09.013

Cited by 43 publications

(34 citation statements)

References 32 publications

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“…These data provide new evidence of the role of local genetic diversity and migration events during CPV evolution and, emphasize the dynamic changes in CPV variants and highlight the importance of ongoing surveillance programs to provide a better understanding of the virus epidemiology (P erez et al, 2012;Maya et al, 2013). However, this variability did not happen within certain countries, like Hungary (Demeter et al, 2010;Decaro et al, 2013;Cs agola et al, 2014), Japan (Ohshima et al, 2008;Soma et al, 2013) and China (Zhang et al, 2010;Yi et al, 2014), where different studies during several years showed the presence of the same predominant variant type. Based on these data, the three different antigenic variants of parvovirus, 2a, 2b and 2c, are currently circulating worldwide, being however difficult to state which is predominant.…”

Section: The Temporal and Geographic Variability And The Relative Frementioning

confidence: 80%

“…The prevalence of CPV-2b (VP2 426Asp) has been reported in several countries within the five continents ( Table 1), and that was found to be the predominant antigenic variant in Ireland (McElligott et al, 2011), the UK , the USA (Hong et al, 2007), African countries (Steinel et al, 1998;Touihri et al, 2009;Dogonyaro et al, 2013) and in four of nine Asian countries (Nakamura et al, 2004;Kumar & Nandi, 2010;Ahmed et al, 2012;Soma et al, 2013). Both CPV-2a and -2b were distributed in equal proportion in Belgium (Decaro et al, 2013), Switzerland and Austria where these antigenic types were exclusively isolated .…”

Section: The Worldwide Distribution Of Antigenic Cpv-2 Variants Spreamentioning

confidence: 99%

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Canine parvovirus: the worldwide occurrence of antigenic variants

Miranda

Thompson

2016

Journal of General Virology

188

222

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Section: The Temporal and Geographic Variability And The Relative Frementioning

confidence: 80%

Section: The Worldwide Distribution Of Antigenic Cpv-2 Variants Spreamentioning

confidence: 99%

Canine parvovirus: the worldwide occurrence of antigenic variants

Miranda

Thompson

2016

Journal of General Virology

188

222

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“…Previous studies have reported that a distinct mutation, Tyr324Ile, frequently occurs in the VP2 gene of CPV-2 from Asian, South American and European countries, including China [13,17], Korea [12,27], Thailand [28], Japan [29], India [30,31], Taiwan [32], Uruguay [33] and Hungary [34]. Phylogenetic analysis indicated that the Uruguayan CPV-2a strain is related to CPV-2a strains from China collected during 2006–2009 [33].…”

Section: Discussionmentioning

confidence: 99%

First Isolation of New Canine Parvovirus 2a from Tibetan Mastiff and Global Analysis of the Full-Length VP2 Gene of Canine Parvoviruses 2 in China

Zhong

Liang

Zhao

et al. 2014

IJMS

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Canine parvovirus 2 (CPV-2) was first identified in 1978, and is responsible for classic parvoviral enteritis. Despite the widespread vaccination of domestic carnivores, CPVs have remained important pathogens of domestic and wild carnivores. In this study, we isolated CPV-2 from Tibetan mastiffs and performed a global analysis of the complete VP2 gene sequences of CPV-2 strains in China. Six isolates were typed as new CPV-2a, according to key amino acid positions. On a phylogenetic tree, these six sequences formed a distinct clade. Five isolates occurred on the same branch as KF785794 from China and GQ379049 from Thailand; CPV-LS-ZA1 formed a separate subgroup with FJ435347 from China. One hundred ninety-eight sequences from various parts of China and the six sequences isolated here formed seven distinct clusters, indicating the high diversity of CPVs in China. Of 204 VP2 sequences, 183 (91.04%) encoded the mutation Ser297Ala, regardless of the antigenic type, implying that most Chinese CPV-2 strains contain the VP2 mutation Ser297Ala. However, the biological significance of this change from prototype CPV-2a/2b to new CPV-2a/2b types remains unclear. This study is the first to isolate new CPV-2a from the Tibetan mastiff. Our data show that new CPV-2a/2b variants are now circulating in China.

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“…In Asia, CPV-2a and 2b are currently predominant in Japan [56,57] , Taiwan [58,59] , and South Korea [60,61] . In Vietnam, CPV-2c [42] is often used as a reference strain for the naturally occurring Vietnamese HNI-4-1 prototype [45] .…”

Section: Prevalence Of Canine Parvovirus Type 2 Variantsmentioning

confidence: 99%

Canine Parvoviruslar Üzerine Güncelleme: Canine Konakçıyı Etkileyen Genetik Varyasyonlara Vurgu Yaparak Moleküler ve Genomik Yönler

Vannamahaxay¹,

Chuammitri²

2017

Kafkas Univ Vet Fak Derg

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Citation of This ArticleVannamahaxay S, Chuammitri P: Update on canine Parvovirus: Molecular and genomic aspects, with emphasis on genetic variants affecting the canine host. Kafkas Univ Vet Fak Derg, 23 (5): 847-856, 2017847-856, . DOI: 10.9775/kvfd.2017 AbstractCanine parvovirus (CPV), the etiology of hemorrhagic enteritis in dogs, was first isolated as CPV type 2 (CPV-2) almost 40 years ago, and was soon replaced by the emergence of new variant types. The major viral capsid proteins encoded by the VP2 gene are the sites where amino acids are often substituted, accounting for the unusual nature of this type of DNA virus. The alteration of specific residues has contributed to different antigenic variants which have affected the evolution of virus binding and host immunity to this virus. Sequence analysis of the VP2 gene and subsequent characterization have revealed three circulating CPV-2 strains, CPV-2a, CPV-2b, and CPV-2c, identified by mutations at amino acid residue 426. The latter strain displays increased pathogenicity in dogs and an extended host range. The present review article aimed at updating contemporary information on epidemiological studies and surveys from CPV field work. Moreover, we pointed out some sensitive and rapid diagnostic tools for detecting CPV in clinical samples, techniques which will be useful for health monitoring and management of CPV with currently available vaccines. Keywords: Canine Parvovirus, CPV type 2, Genetic Variation, VP2 Gene, Mutation, Dog Köpek Parvovirusu Üzerine Bir Güncelleme: Köpek Konakçıya Etki Eden Genetik Varyasyonların Moleküler ve Genomik Özellikleri ÖzetKöpeklerde hemorajik enteritin etiyolojik etkeni olan Canine parvovirus (CPV) neredeyse 40 yıl önce ilk olarak CPV tip 2 (CPV-2) olarak izole edildi ve hemen sonrasında ortaya çıkan yeni varyant tipler CPV tip 2'nin yerine geçti. VP2 geni tarafından kodlanan major viral kapsid proteinler aynı zamanda en sıklıkla amino asitlerin başka amino asitlerle değiştiği alanlar olup bu tip DNA virusların aykırı doğasının da sebebini oluşturmaktadır. Spesifik yapılardaki değişimler farklı antijenik varyantların oluşmasına katkıda bulunarak bu virüsün bağlanma ve virusa karşı konakçı bağışıklığının değişmesini etkilemiştir. VP2 geninin sekans analizi ve takibinde karakterizasyonu, 426. amino asitte mutasyon ile şekillenen CPV2a, CPV-2b ve CPV-2c olmak üzere dolaşımda 3 farklı CPV-2 suşunun olduğunu göstermiştir. CPV-2c köpeklerde artmış patojenite ve daha geniş konakçı yelpazesi göstermektedir. Bu derlemede güncel epidemiyolojik çalışmalar ile CPV saha çalışmaları hakkındaki bilgilerin güncellenmesi amaçlanmıştır. Ayrıca, klinik örneklerde CPV'nin tanısında kullanılmak suretiyle sağlık taramasında faydalı olabilecek ve mevcut aşılarla CPV'nin kontrol altına alınmasında faydalı olabilecek bazı hassas ve hızlı tanı yöntemleri değerlendirilmiştir.

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Analysis of the VP2 protein gene of canine parvovirus strains from affected dogs in Japan

Cited by 43 publications

References 32 publications

Canine parvovirus: the worldwide occurrence of antigenic variants

Canine parvovirus: the worldwide occurrence of antigenic variants

First Isolation of New Canine Parvovirus 2a from Tibetan Mastiff and Global Analysis of the Full-Length VP2 Gene of Canine Parvoviruses 2 in China

Canine Parvoviruslar Üzerine Güncelleme: Canine Konakçıyı Etkileyen Genetik Varyasyonlara Vurgu Yaparak Moleküler ve Genomik Yönler

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