We present results for B-meson decay modes involving a charm meson, protons, and pions using 455×10 6 BB pairs recorded by the BABAR detector at the SLAC PEP-II asymmetric-energy e + e − collider. The branching fractions are measured for the following ten decays:, and B − →D * + ppπ − π − . The four B − and the two five-body B 0 modes are observed for the first time. The four-body modes are enhanced compared to the three-and the five-body modes. In the three-body modes, the M (pp) and M (D ( * )0 p) invariant mass distributions show enhancements near threshold values. In the four-body mode B 0 →D + ppπ − , the M (pπ − ) distribution shows a narrow structure of unknown origin near 1.5 GeV/c 2 . The distributions for the five-body modes, in contrast to the others, are similar to the expectations from uniform phase-space predictions.