Total ionizing dose (TID) radiation effects in the bipolar voltage comparator with different biases and dose rates were investigated in this paper. The experimental results show that offset voltages shift after irradiation. Dominated by the current gain degradation of differential PNP transistors, the shifts of offset voltage and output characteristics were significantly affected by biases at high dose rate. Dominated by the current gain degradation of NPN transistors, the shifts of offset voltage and output characteristics were similar in all biases at low dose rate.