Analysis of trace element  in intervertebral disc by Atomic Absorption Spectrometry techniques in degenerative disc disease in the Polish population

Nowakowski, Andrzej; Kubaszewski, Łukasz; Frankowski, Marcin; Wilk-Frańczuk, Magdalena; Zioła-Frankowska, Anetta; Czabak-Garbacz, R; Kaczmarczyk, Jacek; Gasik, Robert

doi:10.5604/12321966.1152096

Cited by 13 publications

(12 citation statements)

References 20 publications

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“…In the current study, the content of magnesium was similar to the results reported by Nowakowski et al [ 48 ] (949.1 mg/kg in the intervertebral discs vs. 1024.56 mg/kg in our study).…”

Section: Discussionsupporting

confidence: 92%

The Content of Structural and Trace Elements in the Knee Joint Tissues

Roczniak

Brodziak-Dopierała

Cipora

et al. 2017

IJERPH

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Many elements are responsible for the balance in bone tissue, including those which constitute a substantial proportion of bone mass, i.e., calcium, phosphorus and magnesium, as well as minor elements such as strontium. In addition, toxic elements acquired via occupational and environmental exposure, e.g., Pb, are included in the basic bone tissue composition. The study objective was to determine the content of strontium, lead, calcium, phosphorus, sodium and magnesium in chosen components of the knee joint, i.e., tibia, femur and meniscus. The levels of Sr, Pb, Ca, P, Na and Mg were the highest in the tibia in both men and women, whereas the lowest in the meniscus. It should be noted that the levels of these elements were by far higher in the tibia and femur as compared to the meniscus. In the components of the knee joint, the level of strontium showed the greatest variation. Significant statistical differences were found between men and women only in the content of lead.

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“…In the current study, the content of magnesium was similar to the results reported by Nowakowski et al [ 48 ] (949.1 mg/kg in the intervertebral discs vs. 1024.56 mg/kg in our study).…”

Section: Discussionsupporting

confidence: 92%

The Content of Structural and Trace Elements in the Knee Joint Tissues

Roczniak

Brodziak-Dopierała

Cipora

et al. 2017

IJERPH

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“…Research on the content of trace elements and components of the bone tissue concern mainly the hip joint [15, 20–25], vertebrae [26, 27] and ribs [28–31]. In contrast, research on the knee joint is quite rare [32, 33].…”

Section: Introductionmentioning

confidence: 99%

Factors that Affect the Content of Cadmium, Nickel, Copper and Zinc in Tissues of the Knee Joint

Roczniak

Brodziak-Dopierała

Cipora

et al. 2017

Biol Trace Elem Res

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Osteoarthritis causes the degradation of the articular cartilage and periarticular bones. Trace elements influence the growth, development and condition of the bone tissue. Changes to the mineral composition of the bone tissue can cause degenerative changes and fractures. The aim of the research was to determine the content of cadmium (Cd), nickel (Ni), copper (Cu) and zinc (Zn) in the tibia, the femur and the meniscus in men and women who underwent a knee replacement surgery. Samples were collected from 50 patients, including 36 women and 14 men. The determination of trace elements content were performed by ICP-AES method, using Varian 710-ES. Average concentration in the tissues of the knee joint teeth amounted for cadmium 0.015, nickel 0.60, copper 0.89 and zinc 80.81 mg/kg wet weight. There were statistically significant differences in the content of cadmium, copper and zinc in different parts of the knee joint. There were no statistically significant differences in the content of cadmium, nickel, copper and zinc in women and men in the examined parts of the knee joint. Among the elements tested, copper and nickel showed a high content in the connective tissue (the meniscus) compared to the bone tissue (the tibia and the femur).

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“…The essentiality of elements is to some degree connected with their tissue concentration in dry mass, reflecting the number of biochemical processes in which they take part. The metabolically significant elements are usually within concentration ranges expressed in mg/kg, e.g., magnesium, zinc, or copper (Nowakowski et al 2015 ; Kubaszewski et al 2014 ). Potentially significant elements are within one order of magnitude lower concentration ranges, i.e., μg kg −1 d.w. Ni, Co, Mo with the available analytical techniques they may not be detected in every sample (Kubaszewski et al 2014 ).…”

Section: Introductionmentioning

confidence: 99%

“…One of such tissues is the intervertebral disc (IVD). In IVD, both collagen dysfunction and glycosaminoglycan decomposition are considered a direct cause of the degeneration process, with loss of the biomechanical function—clinically symptomatic back pain, resulting in substantial costs to the health care system (Nowakowski et al 2015 ). To our knowledge, there have been no analyses or published papers on silicon concentration in degenerated IVD.…”

Section: Introductionmentioning

confidence: 99%

Interrelationship between silicon, aluminum, and elements associated with tissue metabolism and degenerative processes in degenerated human intervertebral disc tissue

Zioła-Frankowska

Kubaszewski

Dąbrowski

et al. 2017

Environ Sci Pollut Res

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There is a growing body of evidence concerning the significant role of silicon in development and composition of both connective and bone tissue. Bio-essential silicon shows strong chemical and biological affinity to aluminum, which is toxic and biologically inessential element. The presence of silicon was confirmed in a variety of tissues; however, it has never been examined in intervertebral disc tissue, neither in healthy nor in degenerated one. In this paper, for the first time in the literature, we present the content of silicon in the degenerated intervertebral disc tissue. We also compared the results of silicon analysis with aluminum values in degenerated intervertebral disc tissue in humans. We used chemometric methods to find correlations and similarities between silicon, aluminum, and elements associated with tissue metabolism (Mg) and degenerative processes (Zn and Cu). The presence of silicon was confirmed in all 30 samples harvested from 22 patients operated on due to degenerative changes. Its concentration was within the range of 5.37–12.8 μg g−1 d.w., with the mean concentration of 7.82 μg g−1 d.w. The analysis showed significant correlation between Si and both Al and Mg and weak or negative correlation with Zn and Cu, where the latter was probably the result of degenerative processes. Although silicon is considered essential in glycosaminoglycan and collagen synthesis in connective tissue, it did not show any correlation nor similarities with elements reflecting changes associated with the degenerative process of the intervertebral disc. Silicon showed significant correlation with aluminum, similar to those observed in other human tissues.

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Analysis of trace element in intervertebral disc by Atomic Absorption Spectrometry techniques in degenerative disc disease in the Polish population

Cited by 13 publications

References 20 publications

The Content of Structural and Trace Elements in the Knee Joint Tissues

The Content of Structural and Trace Elements in the Knee Joint Tissues

Factors that Affect the Content of Cadmium, Nickel, Copper and Zinc in Tissues of the Knee Joint

Interrelationship between silicon, aluminum, and elements associated with tissue metabolism and degenerative processes in degenerated human intervertebral disc tissue

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