Analysis of trace elements in scalp hair of healthy people, hyperplasia and breast cancer patients with XRF method

Kolmogorov, Yuriy; Kovaleva, Valentina; Гончар, А. Г.

doi:10.1016/s0168-9002(00)00236-9

Cited by 45 publications

(36 citation statements)

References 4 publications

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“…Association of Cr intake with respiratory, lung and nasal cancers has also been reported (Langard and Vigander 1983;Hayes et al 1989;Davies et al 1991). Significantly higher Cr and Zn levels and lower levels of Cu were reported in the scalp hair of patients with malignant tumours than in the scalp hair of healthy donors (Kolmogorov et al 2000), evidencing that higher hair Cr and Zn contents indicated increased cancer risk. Moreover, Cr and Zn had been reported to be significantly higher in the blood of breast cancer patients as compared with healthy donors (Singh and Garg 1998), and had been significant experimental evidence that Cr stimulate oxygen radical production which induces DNA damage (Clodfelder et al 2004).…”

Section: Resultsmentioning

confidence: 70%

Comparative distribution of the scalp hair trace metal contents in the benign tumour patients and normal donors

Pasha

Malik

Iqbal³

et al. 2008

Environ Monit Assess

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The scalp hair samples of benign tumour patients (n = 77) and normal donors (n = 86) were analysed for selected trace metal contents using atomic absorption spectrophotometry. In the scalp hair of benign tumour patients, highest average levels were found for Ca (1,401 microg/g), followed by Na (476.9 microg/g), Mg (441.6 microg/g), Zn (438.3 microg/g), K (119.2 microg/g) and Fe (96.38 microg/g) while in comparison, the maximum mean levels in the scalp hair of normal donors were shown by Ca (556.5 microg/g), followed by Zn (154.2 microg/g), Mg (153.4 microg/g), Na (97.45 microg/g) and Fe (81.68 microg/g). Almost all metal levels revealed higher dispersion and asymmetry in the scalp hair of benign tumour patients compared with the normal donors. The average concentrations of Ca, Cd, Co, K, Mg, Mn, Na, Ni, Pb, Sb, Sr and Zn were significantly higher in the hair of benign tumour patients compared with the normal donors. Significant gender-based differences were also observed in the scalp hair metal contents of benign tumour patients. Strong positive correlations were found between Cd-Cr (0.547) and Cd-Co (0.507) in the hair of benign tumour patients whereas Ca-Mg, Mg-Sr, Co-Cd, Cr-Cd, Li-Cr, Li-Co, Li-Cd, Na-Cd, Na-Co and Na-Li exhibited strong relationships (r > 0.50) in the hair of normal donors. Cluster analysis (CA) and principal component analysis (PCA) were used for the source identification and apportionment of scalp hair trace metals in the two donor groups. The scalp hair of benign tumour patients and normal donors revealed six and five main clusters of trace metals, respectively. PCA extracted seven principal components of trace metals in the scalp hair of benign tumour patients while six principal components were observed in the case of normal donors. The study evidenced significantly different patterns of metal distribution in the hair of benign tumour patients in comparison with normal donors.

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Section: Resultsmentioning

confidence: 70%

Comparative distribution of the scalp hair trace metal contents in the benign tumour patients and normal donors

Pasha

Malik

Iqbal³

et al. 2008

Environ Monit Assess

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“…The hair samples were subjected to the surface cleaning treatment according to IAEA recommendation [5]. The hair samples (about 0.050 g each) were prepared for XRF analysis using the procedure reported by Khuder et al [14].…”

Section: Sample Preparationmentioning

confidence: 99%

Trace elements in scalp hair of leukaemia patients

et al. 2014

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Abstract. The aim of this study was to determine the concentration of Fe, Ni, Cu, Zn and Pb in scalp hair of leukaemia patients and healthy volunteers, using the optimised XRF method. Leukaemia hair samples were classifi ed corresponding to type, growth and age of the participants. The results showed that the studied trace elements (TEs) in both of leukaemia and control groups were positively skewed. In comparison with the control group, lower Fe, Cu, Zn and Pb and higher of Ni medians were found in all studied leukaemia patients. The median rank obtained by Mann-Whitney U-test revealed insignifi cant differences between the leukaemia patients subgroups and the controls. An exact probability ( < 0.05) associated with the U-test showed signifi cant differences between medians in leukaemia patients and controls groups for Pb (lymphatic/control, acute/control), Cu (lymphatic/control, chronic/control), Ni (lymphatic/control, chronic/control) and Fe (chronic/control). Very strong positive and negative correlations (r > 0.70) in the scalp hair of control group were observed between Ni/Fe-Ni, Cu/Fe-Cu, Zn/Fe-Zn, Pb/Fe-Pb, Cu/Ni-Zn/Ni, Cu/Ni-Pb/Ni, Zn/Ni-Pb/Ni, Zn/Fe-Zn/Cu, Pb/Ni-Ni and Ni/Fe-Pb/Ni, whereas only very strong positive ratios in the scalp hair of leukaemia patients group were observed between Ni/Fe-Ni, Cu/Fe-Cu, Zn/Fe-Zn and Pb/Fe-Pb, all correlations were signifi cant at p < 0.05. Other strong and signifi cant correlations were also observed in scalp hair of both groups. Signifi cant differences between grouping of studied TEs in all classifi ed leukaemia groups and controls were found using principal component analysis (PCA). The results of PCA confi rmed that the type and the growth of leukaemia factors were more important in element loading than the age factor.

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“…Hair samples were selected from different points of the head and subjected to the surface cleaning treatment according to IAEA recommendation (Kolmogorov et al 2000), fragmented and kept in polyethylene bottles for further analysis.…”

Section: Population Testedmentioning

confidence: 99%

“…Studies showed that scalp hair can record the level and changes of many elements in the body over a long period of time (Saiki et al 1998). Changes in the elemental composition of hair are believed to depend on alterations of external and internal media of the human body, and it is considered that the hair of healthy individuals contains each element within a well defined range of concentration (Kolmogorov et al 2000;Man et al 1996), and it can be considered as a potential indicator of both external and internal longterm exposure to environmental pollutants.…”

Section: Introductionmentioning

confidence: 99%

“…Various different techniques such as neutron activation analysis (NAA; Abugassa et al 1999;Faghihian and Rahbarnia 2002;Lin and Henkelmann 2003;Menezes et al 2004), atomic absorption spectrometry (AAS; Sturaro et al 1993), and atomic emission spectrometry (AES; Asfaw and Wibetoe 2004;Matusiewicz and Kopras 2003) have been employed in the detection of trace metals presented in human hair. X-ray fluorescence (XRF) spectrometry is also applied to hair analysis (Dede et al 2001;Kolmogorov et al 2000), although the determination of some trace elements, such Pb, Ni, Mn, and Cr, produces particular difficulties. Total reflection X-ray fluorescence (TXRF) is a special method of XRF analysis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determination of nickel, copper, zinc and lead in human scalp hair in Syrian occupationally exposed workers by total reflection X-ray fluorescence

Khuder

Bakir

Hasan

et al. 2007

Environ Monit Assess

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The concentrations of Ni, Cu, Zn, and Pb in human scalp hair of 281 individuals working in 10 Syrian industrial plants were determined using co-precipitation by ammoniumpyrolidinedithiocarbamate (APDC) method for total reflection X-ray fluorescence (TXRF) analysis. The results were compared to data obtained for a control group consisted of individuals working at the Syrian Atomic Energy Commission and also to data reported in the literature. The results given by the group of workers in battery plant showed that Pb concentration in human scalp hair samples were higher than those for control group, while some abnormal concentrations were obtained for Cu, Zn and Ni in cables, printing and battery plants, respectively. Normal concentrations of these elements were obtained for hair workers in olive oil, power stations, textile, and iron industrial plants. The relationships of Pb-Pb/Ni and Cu-Cu/Ni were plotted with correlation coefficients of 0.9937 and 0.9014, respectively. In general, the results showed that, the workers who were occupationally exposed to battery industrial pollution are at risk, followed by individuals in printing and cables industries, while the rest of workers in other industries are considered occupationally unexposed.

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Analysis of trace elements in scalp hair of healthy people, hyperplasia and breast cancer patients with XRF method

Cited by 45 publications

References 4 publications

Comparative distribution of the scalp hair trace metal contents in the benign tumour patients and normal donors

Comparative distribution of the scalp hair trace metal contents in the benign tumour patients and normal donors

Trace elements in scalp hair of leukaemia patients

Determination of nickel, copper, zinc and lead in human scalp hair in Syrian occupationally exposed workers by total reflection X-ray fluorescence

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