Analysis of Traditional Chinese Medicine Symptoms in Children with Spastic Cerebral Palsy, a Protocol for Data Mining

Wang, Xing; Pang, Fang; Du, Xiao-Gang

doi:10.2147/jmdh.s426969

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…XN2023-13) was obtained from the hospital’s ethics committee. The study protocol with more information was published on October 25, 2023, 18 maintaining the core aspects of the research design while adjusting certain research details, such as utilizing the R language for cluster analysis and association rule analysis. The specific flowchart of the research process is depicted as Figure 1 .…”

Section: Methods and Analysismentioning

confidence: 99%

Analysis of Traditional Chinese Medicine Symptoms in Children with Spastic Cerebral Palsy: A Data Mining Study

Wang,

Pang,

2024

JMDH

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Background Cerebral palsy (CP) ranks as a major cause of motor disabilities in children, with spastic CP making up roughly 70–80% of all CP cases. The primary objective of our study is to identify characteristics of Traditional Chinese Medicine(TCM) symptom of spastic CP, thereby establishing correlations between the TCM symptom and the disease, providing a more scientific theoretical foundation for TCM treatments on spastic CP, enabling a deeper comprehension of clinical interventions, ultimately, improving rehabilitation outcomes in TCM treatment for spastic CP. Methods We conducted a data mining study on TCM symptom of spastic CP children aged 4–14 years old treated at Xi’an Encephalopathy Hospital Affiliated to Shaanxi University of Chinese Medicine, from October 2021 to March 2023. The medical records of all eligible and complete spastic CP patients were extracted, processed for data cleansing, transformed, and subsequently analyzed to discern distinctive TCM symptom. K-Means Clustering Analysis and Association Rule Analysis were used for data mining. Results Core symptoms identified for spastic CP encompassed “Motor Dysfunction”, “Impaired Speech”, “Delayed Development”, “Limb Stiffness”, “Rigidity in the limbs”, “Intellectual Impairment”, “Timidity and susceptibility to startle responses”, “Muscle Wasting”, and “Pale or Dull Complexion”. Among the top-ranking associations of symptom, patterns emerge wherein “Motor dysfunction” intertwine with “Impaired speech”, “Motor dysfunction” coexist with “Delayed development”, and “Impaired speech” are accompanied by “Delayed development”. Conclusion This study identified the core symptom of spastic CP and tentatively suggests that the clinical manifestations of spastic CP are essentially consistent with the TCM pattern “liver exuberance and spleen weakness”. This finding has facilitated the preliminary establishment of correlations between TCM pattern differentiation and the disease in medicine. It is anticipated that this correlation will bring tangible benefits to a larger number of children with spastic CP.

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Section: Methods and Analysismentioning

confidence: 99%

Analysis of Traditional Chinese Medicine Symptoms in Children with Spastic Cerebral Palsy: A Data Mining Study

Wang,

Pang,

2024

JMDH

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Exploiting the nanotechnological approaches for traditional Chinese medicine in childhood rhinitis: A review of future perspectives

Zhang,

Dong,

Zhu

et al. 2024

Nanotechnology Reviews

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Childhood rhinitis is an inflammatory condition affecting the nasal mucosa of children worldwide. The physical, social, and cognitive performance of children is affected by the chronic symptoms of childhood rhinitis. Effective treatment is essential to avoid long-term effects on children’s lifestyles and well-being. Traditional Chinese medicine (TCM) has been used to treat and prevent several illnesses, and it plays a crucial role in healthcare and rehabilitation. TCM has traditionally been used to holistically treat rhinitis. However, the drawbacks of TCMs, such as their poor water solubility, low bioavailability, single-use, and poor targeting ability, severely restrict their use. In recent years, nanotechnology has been used for various drugs to improve their therapeutic effectiveness and reduce their associated adverse effects. Nanomaterials for TCM formulations are synthesized to be compatible with herbal extracts and sustain active component therapeutic qualities. Nanocarrier-based drug delivery improves bioavailability, circulation time, and targeted distribution, resolving TCM administration issues. This review assesses the innovative combination of TCM and nanotechnology developments for the treatment of childhood rhinitis, providing insights into novel therapeutic approaches. This review also provides significant insights into the potential of this multidisciplinary approach to transform treatment techniques in childhood rhinitis and offers a road map for future research initiatives in this promising sector.

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Literature study on traditional Chinese medicine syndromes after renal transplantation

Guo,

Bao,

Wang

et al. 2025

World J Transplant

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BACKGROUND Kidney transplantation is the most effective means to treat patients with renal failure, but its postoperative problems such as rejection reactions, immunosuppressant poisoning, chronic transplant kidney nephropathy, etc. still have not been effectively solved. This study searched for literature on traditional Chinese medicine (TCM) syndromes after kidney transplantation in China, conducted statistical analysis of the results, and sought to identify the underlying patterns. AIM To understand the TCM syndromes after renal transplantation and associated rules and provide a theoretical basis for further clinical research. METHODS The literature pertaining to TCM syndromes in renal transplantation, published in the China National Knowledge Infrastructure, Wanfang database, and WIP database from 1970 to 2021, was meticulously searched and comprehensively and statistically analyzed. RESULTS Following the established inclusion and exclusion criteria, 13 studies were selected for analysis. Post-renal transplantation, no significant discrepancy was noted among the groups based on the location of TCM viscera. However, when categorized according to TCM pathogenic factors, the groups with spleen and kidney yang deficiency, as well as liver and kidney yin deficiency, exhibited a statistically significant difference in the frequency. CONCLUSION Currently, the research on TCM syndromes pertaining to renal transplantation is in its nascent phase. It is imperative to conduct a multicentric, large-scale survey of TCM syndromes subsequent to renal transplantation in the ensuing years.

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Analysis of Traditional Chinese Medicine Symptoms in Children with Spastic Cerebral Palsy, a Protocol for Data Mining

Cited by 3 publications

References 35 publications

Analysis of Traditional Chinese Medicine Symptoms in Children with Spastic Cerebral Palsy: A Data Mining Study

Analysis of Traditional Chinese Medicine Symptoms in Children with Spastic Cerebral Palsy: A Data Mining Study

Exploiting the nanotechnological approaches for traditional Chinese medicine in childhood rhinitis: A review of future perspectives

Literature study on traditional Chinese medicine syndromes after renal transplantation

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