Analysis of trends in lumbar disc degeneration using kinematic MRI

Roberts, Sidney; Gardner, Carson; Jiang, Zhenhuan; Abedi, Aidin; Buser, Zorica; Wang, Jeffrey C.

doi:10.1016/j.clinimag.2021.04.028

Cited by 16 publications

(13 citation statements)

References 28 publications

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“…The fragility of the degenerated disc structure can cause tears in the annulus which can make herniation of the nucleus pulposus structure. (Cao, Guo and Wan, 2020;Roberts et al, 2021) This study proves that there is an inverse relationship between disc height and the degree of degeneration. In the Pearson statistical test it was found that the lower the height of the intervertebral disc, the higher the degree of degeneration and vice versa.…”

Section: Discussionsupporting

confidence: 55%

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relationship between intervertebralis disc height and pfirrmann’s degenerative degree:

Harmawan

Parenrengi

Bajamal

et al. 2022

ijhs

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This study aims to determine the relationship between disc height as objective data and the degree of disc degenerative Pfirrmann score assessed on MRI imaging, the imaging modality with the best current degenerative lumbal disease’s diagnosis. The measurements of disc height and Pfirrmann degenerative degree of the intervertebral disc were performed on a T2WI MRI sequence, sagittal sections of the 1-2 lumbar intervertebral discs to 5-sacral 1 (5 disc levels) using dicom MRI data using the Horos dicom viewer software. Analysis of the correlation between disc height and the degree of degeneration on MRI was performed using the Pearson correlation test. Statistical tests were performed using SPSS software (SPSS Inc., Chicago, IL, USA). The results were evaluated with a significance value of p<0.005. The results of the Pearson test in the three groups of patients, namely in the HNP L4-L5, HNP L5-S1 and HNP patient groups at both disc levels showed an inverse relationship between disc height and Pfirrmann's degenerative degree which was statistically significant, with values in the L4 HNP group.

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Section: Discussionsupporting

confidence: 55%

“…Variations in hydration state and disc composition can be detected noninvasively by quantitative MRI with good accuracy. (da Costa et al, 2020;Kreiner et al, 2020;Roberts et al, 2021;Rosyid, Yamin and Puspitasari, 2019;Widmer et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

relationship between intervertebralis disc height and pfirrmann’s degenerative degree:

Harmawan

Parenrengi

Bajamal

et al. 2022

ijhs

View full text Add to dashboard Cite

show abstract

“…The lack of increased mean angular rotation and sagittal translation observed at the L5-S1 vertebral level on flexion/extension X-rays is also in line with the results of other studies (Golbakhsh et al, 2012;Rathod & Dhake, 2018), despite L5-S1 being a common location of disc degeneration. A recent kinematic MRI study showed that intervertebral disc disease was most common at this level (Roberts et al, 2021) and changes in the morphology of the MF muscle have also been most commonly observed at this vertebral level (Goubert et al, 2016;Wallwork et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Relationship between the morphology and composition of the lumbar paraspinal and psoas muscles and lumbar intervertebral motion in chronic low‐back pain: An exploratory study

et al. 2022

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Muscles of the lumbar spine play an important role in controlling segmental intervertebral motion. This study aimed to evaluate the association between lumbar intervertebral motion and changes in lumbar morphology/composition in people with chronic low-back pain (CLBP). A sample of 183 patients with CLBP participated in this cross-sectional study. Participants underwent lumbar flexion-extension X-rays to determine vertebral motion (translational and/or rotational motion) of lumbar levels (L1-L2 to L5-S1) and lumbar spine magnetic resonance imaging to quantify total and functional cross-sectional areas (CSAs) and asymmetry of the multifidus (MF), lumbar erector spinae (LES), and psoas muscles. The relationship between morphology/ composition of the muscles and lumbar intervertebral motion was investigated. Smaller total and functional CSAs of the MF and greater CSAs of the LES muscle were observed in participants with greater intervertebral motion. Muscle asymmetry was observed at different lumbar vertebral levels. The greatest amount of translational intervertebral motion was observed at the L3-L4 level, while the greatest amount of rotational translation occurred at the L4-L5. Associations were observed between the morphology of the paraspinal muscles at the vertebral levels adjacent to the L3-L4 level and the increased intervertebral motion at this level. Relationships between measures of muscle morphology/composition and increased segmental vertebral motion were observed. The results may provide a plausible biological reason for the effectiveness of rehabilitating deficient paraspinal muscles in a subset of people with CLBP.

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“…Researchers have indicated that it is now possible to measure tau and amyloid beta (Aβ) protein in the brain. Analyses of the association among neuroimaging findings, clinical phenotype, and age were performed as a way to investigate how different neuroimaging modalities relate to disease mechanisms; hence, it is possible to elaborate on the specific cause of, as well as the course of, Alzheimer’s disease ( Benitez et al, 2021 ; Roberts et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Regional Homogeneity in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study

Zhang

Liu

et al. 2022

Front. Aging Neurosci.

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ObjectiveTo analyze the potential changes in brain neural networks in resting state functional magnetic resonance imaging (rs-fMRI) scans by regional homogeneity (ReHo) in patients with mild cognitive impairment (MCI).MethodsWe recruited and selected 24 volunteers, including 12 patients (6 men and 6 women) with MCI and 12 healthy controls matched by age, sex, and lifestyle. All subjects were examined with rs-fMRI to evaluate changes in neural network connectivity, and the data were analyzed by ReHo method. Correlation analysis was used to investigate the relationship between ReHo values and clinical features in different brain regions of MCI patients. The severity of MCI was determined by the Mini-Mental State Examination (MMSE) scale.ResultsThe signals of the right cerebellum areas 4 and 5, left superior temporal, right superior temporal, left fusiform, and left orbital middle frontal gyri in the patient group were significantly higher than those in the normal group (P < 0.01 by t-test of paired samples). The signal intensity of the right inferior temporal and left inferior temporal gyri was significantly lower than that of the normal group (P < 0.01). The ReHO value for the left inferior temporal gyrus correlated negatively with disease duration, and the value for the right inferior temporal gyrus correlated positively with MMSE scores.ConclusionMild cognitive impairment in patients with pre- Alzheimer’s disease may be related to the excitation and inhibition of neural networks in these regions. This may have a certain guiding significance for clinical diagnosis.

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Analysis of trends in lumbar disc degeneration using kinematic MRI

Cited by 16 publications

References 28 publications

relationship between intervertebralis disc height and pfirrmann’s degenerative degree:

relationship between intervertebralis disc height and pfirrmann’s degenerative degree:

Relationship between the morphology and composition of the lumbar paraspinal and psoas muscles and lumbar intervertebral motion in chronic low‐back pain: An exploratory study

Regional Homogeneity in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study

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