2021
DOI: 10.1002/rmb2.12389
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Analysis of vaginal and endometrial microbiota communities in infertile women with a history of repeated implantation failure

Abstract: Purpose To identify specific bacterial communities in vaginal and endometrial microbiotas as biomarkers of implantation failure by comprehensively analyzing their microbiotas using next‐generation sequencing. Methods We investigated α‐ and β‐diversities of vaginal and endometrial microbiotas using 16S rRNA gene sequencing and compared their profiles between 145 women with repeated implantation failure (RIF) and 21 controls who lacked the factors responsible for implantation failure with a high probability of b… Show more

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Cited by 42 publications
(21 citation statements)
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“…Lactobacillus was the most relatively abundant genus in almost all endometrium samples in our study, which is consistent with several previous studies 3 , 5 8 , 28 30 . However, one previous study using endometrial tissue, obtained after hysterectomy, detected hardly any lactobacilli at all 31 .…”
Section: Discussionsupporting
confidence: 93%
“…Lactobacillus was the most relatively abundant genus in almost all endometrium samples in our study, which is consistent with several previous studies 3 , 5 8 , 28 30 . However, one previous study using endometrial tissue, obtained after hysterectomy, detected hardly any lactobacilli at all 31 .…”
Section: Discussionsupporting
confidence: 93%
“…Nonetheless, there were different bacterial compositions, and the RIF group exhibited significant enrichment of 14 genera—including Atopobium , Burkholderia , Delftia , Gardnerella , and Prevotella —but similar abundance of endometrial Lactobacillus spp. [ 11 ]. Lastly, greater levels of L. helveticus , Sneathia amnii , and the genus Prevotella were reported among patients with RIF, and higher numbers of L. iners , L. jensenii , and the genus Ralstonia were found in subjects without RIF [ 79 ].…”
Section: Microbiota Alterations In Infertilitymentioning
confidence: 99%
“…For instance, uterine colonization is hypothesized to occur from gut, oral cavity, bloodstream, and vaginal ascension [ 3 , 5 ], but uterine seeding could potentially occur through assisted reproductive technology (ART) procedures and placement of contraceptive devices [ 6 , 7 ] as well as attachment of microorganisms to human spermatozoa [ 8 ]. Regardless of its origin, research consistently demonstrates that the uterine microbiome is highly diverse and scarcely populated compared with the lower genital tract [ 9 , 10 , 11 ], but its composition remains to be fully unraveled.…”
Section: Introductionmentioning
confidence: 99%
“…Patients with RIF presented higher microbial α-diversity than the control group ( 99 ). Meanwhile, vaginal Lactobacillus in patients with RIF was significantly decreased compared with healthy women, and the vaginal microbiota profiles in patients with RIF had significantly higher levels of five bacterial genera than in healthy women ( 102 ). Therefore, the number of vaginal Lactobacillus spp.…”
Section: Discussionmentioning
confidence: 99%