Analysis of vascular function using the cardio–ankle vascular index (CAVI)

Shirai, Kohji

doi:10.1038/hr.2011.40

Cited by 29 publications

(27 citation statements)

References 10 publications

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“…Contrary to PWV, CAVI is essentially independent of blood pressure at measuring time [14][15][16] because it is calculated by Bramwell-Hill equation, which corrects for blood pressure parameters [12]. Consequently, CAVI represents both 'functional' and 'organic' arterial stiffness [17] and reflects both the state of smooth muscle contraction and mechanical properties of the arterial wall [18]. Moreover, CAVI enables evaluation of the real effect of blood pressure control on arteries during antihypertensive therapy [12,19].…”

Section: Introductionmentioning

confidence: 98%

Association of cardio-ankle vascular index with cardiovascular risk factors and cardiovascular events in metabolic syndrome patients

Laucevičius¹,

Ryliškytė²,

Balsytė³

et al. 2015

Medicina

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Section: Introductionmentioning

confidence: 98%

Association of cardio-ankle vascular index with cardiovascular risk factors and cardiovascular events in metabolic syndrome patients

Laucevičius¹,

Ryliškytė²,

Balsytė³

et al. 2015

Medicina

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“…3 As the most conspicuous feature of CAVI is a lack of dependence on blood pressure, CAVI has been recently utilized for assessing arterial stiffness in clinical settings. 4 CAVI is high in aging patients and in patients with arteriosclerotic disease, such as coronary artery disease, 5 carotid atherosclerosis 6 and chronic kidney disease, 7 and is related to many coronary risk factors such as hypertension, 8 diabetes, 9 dyslipidemia 9 and smoking. 10 Furthermore, the CAVI decreases with control of diabetes and hypertension, as well as abstention from smoking.…”

Section: Introductionmentioning

confidence: 99%

Association between arterial stiffness and pulmonary function in hypertensive patients

et al. 2011

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Arterial stiffness, assessed by cardio-ankle vascular index (CAVI), is clinically used to assess arteriosclerosis. Recently, pulmonary age, as determined by pulmonary function test, has been proposed by the Japanese Respiratory Society as a diagnostic measure for chronic obstructive pulmonary disease (COPD). This study aims to examine the association between CAVI and pulmonary function and to elucidate the correlation between vascular stiffness and pulmonary age in hypertensive patients. We enrolled a total of 45 hypertensive patients (70 ± 9 years) who had been taking antihypertensive medications for at least 1 year. Pulmonary function was measured by the percentage of predicted forced vital capacity (FVC) and the ratio of forced expiratory volume in 1 s (FEV 1 ) to FVC (FEV 1 /FVC ratio). Pulmonary age was determined by the equation proposed by the Japanese Respiratory Society. CAVI was measured at the same clinic visit. In the simple correlation analysis CAVI correlated with the FEV 1 /FVC ratio (r¼À0.399, P¼0.007) and pulmonary age (r¼0.559, Po0.001). Multiple linear regression analysis revealed that CAVI was independently associated with FEV 1 /FVC ratio (b¼À0.418, P¼0.014) and pulmonary age (b¼0.514, P¼0.002). In addition, CAVI was significantly higher in patients with increased pulmonary age (9.4 ± 1.4) than in those with normal pulmonary age (8.4 ± 0.9) (P¼0.011). The present study indicates that an increased CAVI is independently associated with reduced pulmonary function and increased pulmonary age. Hypertensive patients with high CAVI may need to be monitored for the progression of COPD.

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“…It is well known that the CAVI increases with advancing age. 3,4 This may be why the CAVI was eliminated during stepwise multiple regression analyses. However, HbA 1c as an independent determinant of the SBP variability during a single clinic visit may suggest that single-visit SBP variability in patients with glucose intolerance or diabetes may be an indicator of the progression of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…3 As the most conspicuous feature of the CAVI is a lack of dependence on blood pressure, this index has recently become utilized for assessing arterial stiffness in clinical settings. 4 The CAVI is high in ageing patients and in those with atherosclerotic diseases such as coronary artery disease, 5 carotid atherosclerosis, 6 and chronic kidney disease; 7 the index is also related to many coronary risk factors such as hypertension, 8 diabetes, 9 dyslipidaemia and smoking. 9,10 Furthermore, the CAVI decreases with control of diabetes 11 and hypertension, 12 as well as abstention from smoking.…”

Section: Introductionmentioning

confidence: 99%

Relationship between arterial stiffness and variability in systolic blood pressure during a single clinic visit in patients with hypertension

et al. 2013

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Objective: To examine factors affecting systolic blood pressure (SBP) variability during a single clinic visit, in treated hypertensive patients. Methods: Hypertensive patients were recruited to this observational study. Blood pressure was measured using an automated blood pressure monitor when each patient arrived at the outpatient clinic and again when they saw the physician. Mean SBP and SBP variability during a single clinic visit were calculated. The cardio-ankle vascular index (CAVI), as a marker of arterial stiffness, was also measured. Results: A total of 57 treated hypertensive patients (mean age 71 years) were included in the study. The mean SBP was positively correlated with age (r ¼ 0.457), while SBP variability was positively correlated with age (r ¼ 0.383), CAVI (r ¼ 0.330), and glycosylated haemoglobin (r ¼ 0.345) and triglyceride levels (r ¼ 0.299). Conclusion: Variability in SBP during a single clinic visit showed better correlations with arterial stiffness and risk factors for atherosclerosis than did mean SBP. Large SBP variability during a single clinic visit may reflect progression of atherosclerosis, in treated hypertensive patients.

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Analysis of vascular function using the cardio–ankle vascular index (CAVI)

Cited by 29 publications

References 10 publications

Association of cardio-ankle vascular index with cardiovascular risk factors and cardiovascular events in metabolic syndrome patients

Association of cardio-ankle vascular index with cardiovascular risk factors and cardiovascular events in metabolic syndrome patients

Association between arterial stiffness and pulmonary function in hypertensive patients

Relationship between arterial stiffness and variability in systolic blood pressure during a single clinic visit in patients with hypertension

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