Analysis of Vitamin D and Calcium Levels in Benign Paroxysmal Positional Vertigo

Işık, Gülşah Çıkrıkçı; Çevik, Yunsur; Emektar, Emine; Çorbacıoğlu, Şeref Kerem

doi:10.5152/eajem.2017.58077

Cited by 20 publications

(9 citation statements)

References 13 publications

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“…In our study, the comparison of BPPV patients to patients with other vestibular and neurological non‐vestibular disorders and not to healthy controls is unique. Our study supports previous results assuming a coexistence and not an association of the serum 25(OH)D concentration and BPPV occurrence [7,11–13]. As a significant difference of vitamin D levels between various vestibular diseases was not found, it is assumed that other factors more important than the symptom of vertigo or the kind of neurological disease are affecting the vitamin D level and vice versa.…”

Section: Discussionsupporting

confidence: 91%

No evidence for a specific vitamin D deficit in benign paroxysmal positional vertigo

Goldschagg

Teupser

Feil

et al. 2021

Euro J of Neurology

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Benign paroxysmal positional vertigo (BPPV) caused by dislocation of otoconia from the otolith organs into the semicircular canals is one of the most common causes of vertigo. Continuous remodelling of the otoconia, requiring calcium and regulation by vitamin D, seems to be important for the pathogenesis of BPPV. There have been multiple observations of an association between impaired calcium metabolism and BPPV development.First, previous studies showed decreased bone mineral density in BPPV patients [1,2]. Secondly, a seasonal variation of BPPV is reported [3,4]. Thirdly, there are-partially contradictory-results

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Section: Discussionsupporting

confidence: 91%

No evidence for a specific vitamin D deficit in benign paroxysmal positional vertigo

Goldschagg

Teupser

Feil

et al. 2021

Euro J of Neurology

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“…However, the underlying causes of BPPV remain unclear. In recent decades, many studies have investigated risk factors for the occurrence of BPPV, including female gender, serum vitamin D deficiency, osteoporosis, vascular risk factors, head trauma, and other potential risk factors (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). However, there are some controversies among these studies.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for the Occurrence of Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis

et al. 2020

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Background and Purpose: The lifetime prevalence of benign paroxysmal positional vertigo (BPPV) is high, especially in the elderly. Patients with BPPV are more susceptible to ischemic stroke, dementia, and fractures, severely reducing quality of life of patients. Many studies have analyzed risk factors for the occurrence of BPPV. However, the results of these studies are not identical. We performed this meta-analysis to determine potential risk factors associated with the occurrence of BPPV. Methods: PubMed, EMBASE, and the Cochrane Library (January 2000 through March 2020) were systematically searched for eligible studies analyzing risk factors for the occurrence of BPPV. Reference lists of eligible studies were also reviewed. We selected observational studies in English with a control group and sufficient data. Pooled odds ratios (ORs) or the mean differences (MDs) and 95% confidence intervals (CIs) were calculated to measure the impacts of all potential risk factors. Heterogeneity among studies was evaluated using the Q-test and I 2 statistics. We used the randomeffect model or the fixed-effect model according to the heterogeneity among the included studies. Results: We eventually included 19 studies published between 2006 and 2019, including 2,618 patients with BPPV and 11,668 participants without BPPV in total. In this meta-analysis, the occurrence of BPPV was significantly associated with female gender (OR = 1.18; 95% CI, 1.05-1.32; P = 0.004), serum vitamin D level (MD = −2.12; 95% CI, −3.85 to −0.38; P = 0.02), osteoporosis (OR = 2.49; 95% CI, 1.39-4.46; P = 0.002), migraine (OR = 4.40; 95% CI, 2.67-7.25; P < 0.00001), head trauma (OR = 3.42; 95% CI, 1.21-9.70; P = 0.02), and total cholesterol level (MD = 0.32; 95% CI, 0.02-0.62; P = 0.03). Conclusion: Female gender, vitamin D deficiency, osteoporosis, migraine, head trauma, and high TC level were risk factors for the occurrence of BPPV. However, the effects of other risk factors on BPPV occurrence need further investigations.

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“…A few earlier studies correlated the serum levels of vitamin D and calcium with BPPV, with a hypothesis of a higher prevalence of BPPV among people with low levels of vitamin D. Cikrikci et al 19 determined the median serum levels of vitamin D among BPPV patients and healthy controls to be of 9.51 ng/ml and 7.8 ng/ml respectively, but did not find any statistical significance between the cases and controls ( p = 0.99). In the same study, the median total serum level of calcium was of 9.5 mg/dl among the cases, and of 9.43 mg/dl in the control group, with no statistically significant difference between the two groups (r = 0.34).…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Calcium and Vitamin D with Benign Paroxysmal Positional Vertigo

Thomas

Goutham

Bhat

et al. 2021

Int Arch Otorhinolaryngol

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Introduction Benign paroxysmal positional vertigo (BPPV) is one of the common disorders of the peripheral vestibular system. The prevalence of BPPV is found to be higher among middle-aged women. Objectives To estimate the serum levels of calcium and vitamin D in patients with BPPV, and to study their association. Methods The present is a hospital-based prospective case-control study. Venous blood samples of the 49 patients with BPPV and an equal number of age- and gender-matched individuals were recruited and submitted to an analysis of the serum levels of calcium and vitamin D. Results Among the cases, 67.3% were found to be females, and 32.7% were males. Most of the 30 cases (61.3%) were aged > 40 years. The mean age of the cases was 44.39 years. The mean serum level of vitamin D in the cases was of 21.26 ng/ml compared with 17.59 ng/ml in the controls. The mean serum level of calcium was of 9.33 mg/dl in the cases, compared with 8.95 mg/dl in the controls. There was no significant difference in the serum levels of vitamin D and calcium between cases and controls. Conclusion We could not establish any correlation between the serum levels of calcium and vitamin D with BPPV. However, a negative relationship was found between the serum levels of vitamin D and the number of episodes of BPPV (p = 0.012).

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Analysis of Vitamin D and Calcium Levels in Benign Paroxysmal Positional Vertigo

Cited by 20 publications

References 13 publications

No evidence for a specific vitamin D deficit in benign paroxysmal positional vertigo

No evidence for a specific vitamin D deficit in benign paroxysmal positional vertigo

Risk Factors for the Occurrence of Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis

Association of Serum Calcium and Vitamin D with Benign Paroxysmal Positional Vertigo

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